HitPredict

Interactor 1: EPHB1 (P54762)
Ephrin type-B receptor 1 (EC 2.7.10.1) (ELK) (EPH tyrosine kinase 2) (EPH-like kinase 6) (EK6) (hEK6) (Neuronally-expressed EPH-related tyrosine kinase) (NET) (Tyrosine-protein kinase receptor EPH-2)
Gene: EPHB1

Interactor 2: CDC37 (Q16543)
Hsp90 co-chaperone Cdc37 (Hsp90 chaperone protein kinase-targeting subunit) (p50Cdc37) [Cleaved into: Hsp90 co-chaperone Cdc37, N-terminally processed]
Gene: CDC37

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	19567782
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	CDC37_M~PK_Tyr_Ser-Thr, CDC37_N~PK_Tyr_Ser-Thr
Common GO terms	GO:0005829 - cytosol GO:0070062 - extracellular exosome
Homologous interactions	19

Homologous interactions

Color coding for hit scores

	1 984 Hs			1 378
+	Hs
		710842 EPHB2_HUMAN (19-981): 0: 1173: 73.76		CDC37_HUMAN (1-378): 2.04e-169: 479: 100.00
+	Hs
		931856 EPHA5_HUMAN (1-983): 0: 1133: 55.67		CDC37_HUMAN (1-378): 2.04e-169: 479: 100.00
+	Hs
		1147331 EPHA7_HUMAN (1-981): 0: 1128: 56.96		CDC37_HUMAN (1-378): 2.04e-169: 479: 100.00
+	Hs
		932079 EPHA4_HUMAN (13-983): 0: 1127: 59.10		CDC37_HUMAN (1-378): 2.04e-169: 479: 100.00
+	Hs
		710632 EPHA3_HUMAN (14-983): 0: 1117: 55.56		CDC37_HUMAN (1-378): 2.04e-169: 479: 100.00
+	Hs
		1158586 EPHA6_HUMAN (1-982): 0: 1076: 51.65		CDC37_HUMAN (1-378): 2.04e-169: 479: 100.00
+	Hs
		710711 EPHA8_HUMAN (19-982): 0: 1051: 51.73		CDC37_HUMAN (1-378): 2.04e-169: 479: 100.00
+	Hs
		931950 EPHB4_HUMAN (3-975): 0: 1019: 56.43		CDC37_HUMAN (1-378): 2.04e-169: 479: 100.00
+	Hs
		710267 EPHA2_HUMAN (17-977): 0: 1008: 46.74		CDC37_HUMAN (1-378): 2.04e-169: 479: 100.00
+	Hs
		640176 EPHA1_HUMAN (11-973): 0: 935: 41.76		CDC37_HUMAN (1-378): 2.04e-169: 479: 100.00
+	Hs
		181796 EPHB6_HUMAN (2-969): 0: 899: 47.13		CDC37_HUMAN (1-378): 2.04e-169: 479: 100.00
+	Hs
		720240 UFO_HUMAN (131-963): 1.57e-168: 517: 23.10		CDC37_HUMAN (1-378): 2.04e-169: 479: 100.00
+	Hs
		1088185 MERTK_HUMAN (134-906): 3.37e-158: 494: 21.93		CDC37_HUMAN (1-378): 2.04e-169: 479: 100.00
+	Hs
		572928 INSRR_HUMAN (278-912): 3.74e-155: 493: 25.72		CDC37_HUMAN (1-378): 2.04e-169: 479: 100.00
+	Hs
		1055051 TYRO3_HUMAN (131-962): 1.36e-158: 491: 19.33		CDC37_HUMAN (1-378): 2.04e-169: 479: 100.00
+	Hs
		465532 IGF1R_HUMAN (390-883): 2.83e-140: 455: 30.71		CDC37_HUMAN (1-378): 2.04e-169: 479: 100.00
+	Hs
		473427 HCK_HUMAN (579-879): 7.28e-65: 229: 40.07		CDC37_HUMAN (1-378): 2.04e-169: 479: 100.00
+	Hs
		440577 FYN_HUMAN (613-879): 2.53e-64: 228: 42.54		CDC37_HUMAN (1-378): 2.04e-169: 479: 100.00
+	Hs
		439746 INSR_HUMAN (338-537): 7.17e-10: 65.4: 16.82		CDC37_HUMAN (1-378): 2.04e-169: 479: 100.00