HitPredict

Interactor 1: RBBP7 (Q16576)
Histone-binding protein RBBP7 (Histone acetyltransferase type B subunit 2) (Nucleosome-remodeling factor subunit RBAP46) (Retinoblastoma-binding protein 7) (RBBP-7) (Retinoblastoma-binding protein p46)
Gene: RBBP7

Interactor 2: CHD5 (Q8TDI0)
Chromodomain-helicase-DNA-binding protein 5 (CHD-5) (EC 3.6.4.-) (ATP-dependent helicase CHD5)
Gene: CHD5

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.84	1.00	0.919

Property	Details
Experiments	25247294, 26186194, 28514442, 33961781, unassigned3799
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	Helicase_C~WD40, SNF2-rel_dom~WD40
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005829 - cytosol GO:0006338 - chromatin remodeling GO:0016581 - NuRD complex and 1 others more... GO:0042393 - histone binding
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 425 Hs			1 1954
+	Hs
		1088371 RBBP7_HUMAN (1-425): 1.15e-117: 351: 100.00		CHD3_HUMAN (29-1952): 0: 1547: 66.80
+	Hs
		1066410 RBBP4_HUMAN (1-209): 1.71e-39: 148: 12.72		CHD5_HUMAN (1-1954): 0: 1739: 100.00
+	Hs
		142376 PEX7_HUMAN (230-404): 8.01e-25: 105: 19.13		CHD5_HUMAN (1-1954): 0: 1739: 100.00
+	Hs
		1132722 RBBP7_HUMAN (1-425): 1.15e-117: 351: 100.00		CHD4_HUMAN (85-1916): 0: 1489: 71.41
+	Hs
		1088581 NLE1_HUMAN (202-424): 2.44e-45: 165: 20.71		CHD3_HUMAN (29-1952): 0: 1547: 66.80
+	Hs
		1066276 RBBP4_HUMAN (1-209): 1.71e-39: 148: 12.72		CHD3_HUMAN (29-1952): 0: 1547: 66.80
+	Hs
		992714 RACK1_HUMAN (213-405): 5.45e-28: 114: 20.41		CHD3_HUMAN (29-1952): 0: 1547: 66.80
+	Hs
		1066307 RBBP4_HUMAN (1-209): 1.71e-39: 148: 12.72		CHD4_HUMAN (85-1916): 0: 1489: 71.41
+	Hs
		992755 RACK1_HUMAN (213-405): 5.45e-28: 114: 20.41		CHD4_HUMAN (85-1916): 0: 1489: 71.41
+	Hs
		964955 WDR5_HUMAN (311-425): 1.4e-17: 85.2: 22.61		CHD4_HUMAN (85-1916): 0: 1489: 71.41
+	Dm
		356756 CAF1_DROME (1-209): 1.01e-40: 151: 13.16		CHDM_DROME (16-1942): 0: 1334: 49.64
+	Hs
		243650 RBBP7_HUMAN (1-425): 1.15e-117: 351: 100.00		SMCA5_HUMAN (553-1645): 0: 736: 25.48
+	Hs
		703326 RBBP7_HUMAN (1-425): 1.15e-117: 351: 100.00		SMCA1_HUMAN (584-1637): 0: 728: 26.13
+	Hs
		243613 RBBP4_HUMAN (1-209): 1.71e-39: 148: 12.72		SMCA5_HUMAN (553-1645): 0: 736: 25.48
+	Dm
		1173895 CAF1_DROME (1-209): 1.01e-40: 151: 13.16		ISWI_DROME (591-1661): 0: 729: 25.60
+	Hs
		1066525 RBBP4_HUMAN (1-209): 1.71e-39: 148: 12.72		CHD7_HUMAN (485-1618): 0: 731: 29.35
+	Hs
		703300 RBBP4_HUMAN (1-209): 1.71e-39: 148: 12.72		SMCA1_HUMAN (584-1637): 0: 728: 26.13
+	Ce
		836439 LIN53_CAEEL (1-209): 2.02e-41: 153: 14.22		ISW1_CAEEL (572-1646): 0: 661: 24.20
+	Ce
		1018638 LIN53_CAEEL (1-209): 2.02e-41: 153: 14.22		CHD3_CAEEL (1277-1927): 1.38e-83: 307: 25.80
+	Ce
		110292 LIN53_CAEEL (1-209): 2.02e-41: 153: 14.22		LE418_CAEEL (1309-1925): 3.31e-82: 303: 25.42