HitPredict

Interactor 1: STX1A (Q16623)
Syntaxin-1A (Neuron-specific antigen HPC-1)
Gene: STX1A

Interactor 2: SNAB (Q9H115)
Beta-soluble NSF attachment protein (SNAP-beta) (N-ethylmaleimide-sensitive factor attachment protein beta)
Gene: NAPB

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.74	1.00	0.861

Property	Details
Experiments	32296183, 24722188, unassigned1304
Identification Methods	two hybrid, two hybrid array, two hybrid prey pooling approach, validated two hybrid
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	SNAP~SNARE, SNAP~Syntaxin
Common GO terms	GO:0006886 - intracellular protein transport GO:0010807 - regulation of synaptic vesicle priming GO:0070044 - synaptobrevin 2-SNAP-25-syntaxin-1a complex GO:0098978 - glutamatergic synapse
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 288 Hs			1 298
+	Hs
		960354 STX1B_HUMAN (1-288): 5.22e-85: 258: 83.33		SNAB_HUMAN (1-298): 3.44e-116: 338: 100.00
+	Hs
		746223 STX2_HUMAN (1-288): 6.63e-82: 250: 63.89		SNAB_HUMAN (1-298): 3.44e-116: 338: 100.00
+	Mm
		204935 STX1A_MOUSE (1-288): 3.71e-86: 261: 98.26		SNAA_MOUSE (1-293): 4.85e-109: 319: 83.62
+	Rn
		746106 STX1A_RAT (1-288): 3.05e-86: 261: 98.61		SNAA_RAT (1-293): 2.21e-108: 318: 82.94
+	Hs
		933012 STX1A_HUMAN (1-288): 1.67e-84: 256: 100.00		SNAA_HUMAN (1-293): 7.27e-109: 319: 83.96
+	Hs
		1430777 X5D7S1_HUMAN (1-286): 4.46e-66: 208: 85.66		SNAB_HUMAN (1-298): 3.44e-116: 338: 100.00
+	Hs
		1100716 STX3_HUMAN (1-288): 2.82e-64: 205: 62.41		SNAB_HUMAN (1-298): 3.44e-116: 338: 100.00
+	Hs
		1087275 STX4_HUMAN (1-287): 1.23e-63: 203: 43.58		SNAB_HUMAN (1-298): 3.44e-116: 338: 100.00
+	Dm
		1171600 STX1A_DROME (2-287): 2.61e-75: 233: 69.90		SNAP_DROME (5-292): 1.03e-103: 306: 62.15
+	Hs
		933004 STX3_HUMAN (1-288): 2.82e-64: 205: 62.41		SNAA_HUMAN (1-293): 7.27e-109: 319: 83.96
+	Hs
		932999 STX4_HUMAN (1-287): 1.23e-63: 203: 43.58		SNAA_HUMAN (1-293): 7.27e-109: 319: 83.96
+	Hs
		286724 STX11_HUMAN (1-274): 2.88e-54: 179: 29.72		SNAB_HUMAN (1-298): 3.44e-116: 338: 100.00
+	Hs
		286636 STX11_HUMAN (1-274): 2.88e-54: 179: 29.72		SNAA_HUMAN (1-293): 7.27e-109: 319: 83.96
+	Dm
		1171599 STX5_DROME (2-268): 2.16e-51: 176: 16.61		SNAP_DROME (5-292): 1.03e-103: 306: 62.15
+	Dm
		1174532 STX1A_DROME (2-287): 2.61e-75: 233: 69.90		Q9U6R9_DROME (4-265): 3.28e-59: 193: 19.70
+	Hs
		1100712 STX3_HUMAN (1-288): 2.82e-64: 205: 62.41		SNAG_HUMAN (4-251): 6.32e-69: 218: 24.30
+	Dm
		1174540 STX1A_DROME (2-287): 2.61e-75: 233: 69.90		Q9VH25_DROME (42-265): 8.65e-52: 173: 19.03
+	Hs
		286715 STX11_HUMAN (1-274): 2.88e-54: 179: 29.72		SNAG_HUMAN (4-251): 6.32e-69: 218: 24.30
+	Dm
		1174436 STX5_DROME (2-268): 2.16e-51: 176: 16.61		Q9U6R9_DROME (4-265): 3.28e-59: 193: 19.70
+	Dm
		1174440 STX5_DROME (2-268): 2.16e-51: 176: 16.61		Q9VH25_DROME (42-265): 8.65e-52: 173: 19.03