HitPredict

Interactor 1: PKN3 (Q6P5Z2)
Serine/threonine-protein kinase N3 (EC 2.7.11.13) (Protein kinase PKN-beta) (Protein-kinase C-related kinase 3)
Gene: PKN3

Interactor 2: SKAP1 (Q86WV1)
Src kinase-associated phosphoprotein 1 (Src family-associated phosphoprotein 1) (Src kinase-associated phosphoprotein of 55 kDa) (SKAP-55) (pp55)
Gene: SKAP1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.74	1.00	0.861

Property	Details
Experiments	26186194, 28514442, 33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	PH~Pkinase
Common GO terms	GO:0005829 - cytosol
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 889 Hs			1 359
+	Hs
		1082010 PKN2_HUMAN (13-884): 0: 894: 49.26		SKAP1_HUMAN (1-359): 2.76e-125: 366: 100.00
+	Hs
		1160287 PKN3_HUMAN (1-889): 0: 974: 100.00		MYO10_HUMAN (108-245): 2.15e-32: 130: 23.45
+	Hs
		1160283 PKN3_HUMAN (1-889): 0: 974: 100.00		PKHA4_HUMAN (111-267): 1.35e-24: 107: 16.56
+	Hs
		1082035 PKN2_HUMAN (13-884): 0: 894: 49.26		PKHA4_HUMAN (111-267): 1.35e-24: 107: 16.56
+	Hs
		1081971 PKN1_HUMAN (27-883): 0: 888: 51.05		PKHA4_HUMAN (111-267): 1.35e-24: 107: 16.56
+	Hs
		408609 KPCB_HUMAN (401-887): 1.3e-164: 497: 34.14		BTK_HUMAN (105-356): 8.02e-32: 128: 12.72
+	Mm
		930572 KPCG_MOUSE (401-889): 4.51e-156: 476: 33.33		CNKR2_MOUSE (56-301): 2.1e-37: 145: 17.72
+	Hs
		566481 KPCA_HUMAN (379-889): 6.46e-167: 503: 33.65		PKHA4_HUMAN (111-267): 1.35e-24: 107: 16.56
+	Hs
		408682 KPCB_HUMAN (401-887): 1.3e-164: 497: 34.14		PKHA4_HUMAN (111-267): 1.35e-24: 107: 16.56
+	Hs
		681860 AKT1_HUMAN (431-883): 2.39e-158: 473: 34.72		CYH1_HUMAN (77-231): 5.6e-33: 128: 17.22
+	Hs
		616702 KS6B1_HUMAN (521-888): 8.92e-152: 458: 37.60		BTK_HUMAN (105-356): 8.02e-32: 128: 12.72
+	Hs
		981049 KPCT_HUMAN (502-884): 1.34e-148: 456: 40.63		BTK_HUMAN (105-356): 8.02e-32: 128: 12.72
+	Hs
		682210 AKT2_HUMAN (431-883): 8.79e-159: 474: 35.15		PKHA4_HUMAN (111-267): 1.35e-24: 107: 16.56
+	Hs
		682023 AKT1_HUMAN (431-883): 2.39e-158: 473: 34.72		PKHA4_HUMAN (111-267): 1.35e-24: 107: 16.56
+	Hs
		623884 KPCL_HUMAN (521-886): 8.34e-152: 464: 41.85		PKHA4_HUMAN (111-267): 1.35e-24: 107: 16.56
+	Hs
		682092 AKT1_HUMAN (431-883): 2.39e-158: 473: 34.72		CD2AP_HUMAN (262-358): 1.77e-21: 97.6: 25.00
+	Hs
		681933 AKT1_HUMAN (431-883): 2.39e-158: 473: 34.72		ABI1_HUMAN (288-358): 6.21e-21: 95.6: 26.76
+	Hs
		981062 KPCT_HUMAN (502-884): 1.34e-148: 456: 40.63		PKHA4_HUMAN (111-267): 1.35e-24: 107: 16.56
+	Rn
		1144343 AKT3_RAT (431-883): 5.11e-155: 465: 35.08		ABI1_RAT (288-358): 4.13e-21: 96: 26.76
+	Hs
		270445 KS6A5_HUMAN (453-815): 3.64e-96: 321: 21.94		PKHA4_HUMAN (111-267): 1.35e-24: 107: 16.56