HitPredict

Interactor 1: HIF1A (Q16665)
Hypoxia-inducible factor 1-alpha (HIF-1-alpha) (HIF1-alpha) (ARNT-interacting protein) (Basic-helix-loop-helix-PAS protein MOP1) (Class E basic helix-loop-helix protein 78) (bHLHe78) (Member of PAS protein 1) (PAS domain-containing protein 8)
Gene: HIF1A

Interactor 2: X5DP31 (X5DP31)
Aryl hydrocarbon receptor nuclear translocator 2
Gene: ARNT2

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.34	1.00	0.590

Property	Details
Experiments	24722188
Identification Methods	two hybrid array
Interaction Type	physical association

Property	Details
Interacting Pfam domains	HLH~PAS, PAS~PAS, PAS~PAS_11, PAS~PAS_3, PAS_11~PAS_3
Common GO terms	GO:0003700 - DNA-binding transcription factor activity GO:0005634 - nucleus GO:0005737 - cytoplasm
Homologous interactions	19

Homologous interactions

Color coding for hit scores

	1 826 Hs			1 660
+	Hs
		1161409 HIF1A_HUMAN (1-826): 0: 741: 100.00		ARNT2_HUMAN (1-658): 0: 629: 89.88
+	Hs
		693329 HIF1A_HUMAN (1-826): 0: 741: 100.00		ARNT_HUMAN (4-658): 0: 544: 52.40
+	Mm
		923315 HIF1A_MOUSE (1-826): 0: 706: 87.63		ARNT_MOUSE (4-658): 0: 541: 53.35
+	Hs
		132728 HIF1A_HUMAN (1-826): 0: 741: 100.00		BMAL1_HUMAN (15-593): 1.23e-165: 490: 30.31
+	Hs
		92030 D0VY79_HUMAN (1-826): 0: 741: 100.00		BMAL1_HUMAN (15-593): 1.23e-165: 490: 30.31
+	Mm
		1222566 HIF1A_MOUSE (1-826): 0: 706: 87.63		BMAL1_MOUSE (15-593): 3.27e-165: 489: 29.97
+	Hs
		1407420 EPAS1_HUMAN (4-824): 5.72e-171: 518: 41.24		ARNT2_HUMAN (1-658): 0: 629: 89.88
+	Hs
		1161374 HIF1A_HUMAN (1-826): 0: 741: 100.00		EPAS1_HUMAN (50-658): 4.72e-127: 398: 20.32
+	Hs
		1161293 HIF1A_HUMAN (1-826): 0: 741: 100.00		HIF1A_HUMAN (48-604): 2.59e-127: 397: 20.46
+	Hs
		1161449 HIF1A_HUMAN (1-826): 0: 741: 100.00		HIF3A_HUMAN (50-647): 2.65e-117: 366: 18.70
+	Mm
		1081348 HIF1A_MOUSE (1-826): 0: 706: 87.63		HIF3A_MOUSE (52-654): 1.05e-114: 360: 19.23
+	Hs
		693356 EPAS1_HUMAN (4-824): 5.72e-171: 518: 41.24		ARNT_HUMAN (4-658): 0: 544: 52.40
+	Mm
		923311 EPAS1_MOUSE (4-824): 5.45e-165: 503: 40.91		ARNT_MOUSE (4-658): 0: 541: 53.35
+	Hs
		132763 EPAS1_HUMAN (4-824): 5.72e-171: 518: 41.24		BMAL1_HUMAN (15-593): 1.23e-165: 490: 30.31
+	Mm
		1021544 EPAS1_MOUSE (4-824): 5.45e-165: 503: 40.91		BMAL1_MOUSE (15-593): 3.27e-165: 489: 29.97
+	Hs
		1361504 EPAS1_HUMAN (4-824): 5.72e-171: 518: 41.24		BMAL2_HUMAN (48-551): 7.65e-146: 439: 32.35
+	Hs
		1407406 EPAS1_HUMAN (4-824): 5.72e-171: 518: 41.24		EPAS1_HUMAN (50-658): 4.72e-127: 398: 20.32
+	Hs
		1407437 EPAS1_HUMAN (4-824): 5.72e-171: 518: 41.24		HIF3A_HUMAN (50-647): 2.65e-117: 366: 18.70
+	Mm
		1021542 EPAS1_MOUSE (4-824): 5.45e-165: 503: 40.91		HIF3A_MOUSE (52-654): 1.05e-114: 360: 19.23