HitPredict

Interactor 1: H2B2E (Q16778)
Histone H2B type 2-E (H2B-clustered histone 21) (Histone H2B-GL105) (Histone H2B.q) (H2B/q)
Gene: H2BC21

Interactor 2: PARP3 (Q9Y6F1)
Protein mono-ADP-ribosyltransferase PARP3 (EC 2.4.2.-) (ADP-ribosyltransferase diphtheria toxin-like 3) (ARTD3) (DNA ADP-ribosyltransferase PARP3) (EC 2.4.2.-) (IRT1) (NAD(+) ADP-ribosyltransferase 3) (ADPRT-3) (Poly [ADP-ribose] polymerase 3) (PARP-3) (hPARP-3) (Poly[ADP-ribose] synthase 3) (pADPRT-3)
Gene: PARP3

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.44	0.60	0.515

Property	Details
Experiments	17353931
Identification Methods	affinity chromatography technology, anti bait coimmunoprecipitation
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005654 - nucleoplasm
Homologous interactions	18

Homologous interactions

Color coding for hit scores

	1 126 Hs			1 533
+	Hs
		1163265 H2B2E_HUMAN (1-126): 6.72e-54: 166: 100.00		PARP2_HUMAN (3-533): 0: 566: 33.82
+	Hs
		981162 H2B1C_HUMAN (1-126): 1.19e-53: 166: 99.21		PARP2_HUMAN (3-533): 0: 566: 33.82
+	Hs
		755019 H2B1B_HUMAN (1-126): 1.74e-53: 165: 98.41		PARP2_HUMAN (3-533): 0: 566: 33.82
+	Hs
		1323996 H2B3B_HUMAN (1-126): 1.02e-51: 161: 96.03		PARP2_HUMAN (3-533): 0: 566: 33.82
+	Hs
		486962 H2B1O_HUMAN (1-126): 3.26e-54: 167: 99.21		PARP1_HUMAN (1-533): 0: 551: 31.07
+	Hs
		487171 H2B1C_HUMAN (1-126): 1.19e-53: 166: 99.21		PARP1_HUMAN (1-533): 0: 551: 31.07
+	Hs
		487373 H2B2E_HUMAN (1-126): 6.72e-54: 166: 100.00		PARP1_HUMAN (1-533): 0: 551: 31.07
+	Hs
		487610 H2B1H_HUMAN (1-126): 6.3e-54: 166: 98.41		PARP1_HUMAN (1-533): 0: 551: 31.07
+	Hs
		487004 H2B1B_HUMAN (1-126): 1.74e-53: 165: 98.41		PARP1_HUMAN (1-533): 0: 551: 31.07
+	Hs
		487146 H2B1D_HUMAN (1-126): 3.52e-53: 164: 98.41		PARP1_HUMAN (1-533): 0: 551: 31.07
+	Hs
		1381879 H2B1A_HUMAN (1-126): 3.44e-46: 147: 85.04		PARP2_HUMAN (3-533): 0: 566: 33.82
+	Hs
		487521 H2B3B_HUMAN (1-126): 1.02e-51: 161: 96.03		PARP1_HUMAN (1-533): 0: 551: 31.07
+	Hs
		487615 H2B1A_HUMAN (1-126): 3.44e-46: 147: 85.04		PARP1_HUMAN (1-533): 0: 551: 31.07
+	Dm
		380876 H2B_DROME (36-126): 9.53e-47: 148: 95.60		PARP_DROME (14-533): 2.06e-168: 504: 31.04
+	Hs
		659953 H2B1O_HUMAN (1-126): 3.26e-54: 167: 99.21		PARP4_HUMAN (117-533): 1.12e-79: 274: 21.08
+	Hs
		1372337 H2B1H_HUMAN (1-126): 6.3e-54: 166: 98.41		PARP4_HUMAN (117-533): 1.12e-79: 274: 21.08
+	Hs
		257012 H2B1K_HUMAN (1-126): 1.56e-53: 165: 98.41		PARP4_HUMAN (117-533): 1.12e-79: 274: 21.08
+	Hs
		1162953 H2B2E_HUMAN (1-126): 6.72e-54: 166: 100.00		PAR10_HUMAN (326-530): 1.29e-20: 98: 14.82