HitPredict

Interactor 1: H2B (P02283)
Histone H2B
Gene: H2B, His2B;

Interactor 2: PARP (P35875)
Poly [ADP-ribose] polymerase (PARP) (EC 2.4.2.30) (NAD(+) ADP-ribosyltransferase) (ADPRT) (Poly[ADP-ribose] synthase) (Protein ADP-ribosyltransferase Parp) (EC 2.4.2.-)
Gene: PARP

Species: Drosophila melanogaster

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.52	0.60	0.561

Property	Details
Experiments	17827147
Identification Methods	affinity chromatography technology, pull down
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0003677 - DNA binding GO:0006325 - chromatin organization
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 123 Dm			1 994
+	Hs
		1163265 H2B2E_HUMAN (3-123): 9.57e-49: 153: 82.11		PARP2_HUMAN (439-992): 0: 626: 36.51
+	Hs
		755019 H2B1B_HUMAN (3-123): 1.14e-48: 153: 82.11		PARP2_HUMAN (439-992): 0: 626: 36.51
+	Hs
		981162 H2B1C_HUMAN (3-123): 1.52e-48: 153: 81.30		PARP2_HUMAN (439-992): 0: 626: 36.51
+	Hs
		1323996 H2B3B_HUMAN (3-123): 1.15e-46: 148: 81.30		PARP2_HUMAN (439-992): 0: 626: 36.51
+	Hs
		1163321 H2B2E_HUMAN (3-123): 9.57e-49: 153: 82.11		PARP3_HUMAN (472-990): 8.59e-151: 459: 30.20
+	Hs
		1372337 H2B1H_HUMAN (3-123): 5.3e-49: 154: 81.30		PARP4_HUMAN (397-990): 1.09e-122: 412: 19.08
+	Hs
		659953 H2B1O_HUMAN (3-123): 3.31e-49: 154: 82.11		PARP4_HUMAN (397-990): 1.09e-122: 412: 19.08
+	Hs
		257012 H2B1K_HUMAN (3-123): 2.13e-48: 152: 80.49		PARP4_HUMAN (397-990): 1.09e-122: 412: 19.08
+	Hs
		754765 H2B1B_HUMAN (3-123): 1.14e-48: 153: 82.11		DNLI3_HUMAN (4-107): 1.81e-28: 125: 21.05
+	Hs
		892539 H2B1C_HUMAN (3-123): 1.52e-48: 153: 81.30		DNLI3_HUMAN (4-107): 1.81e-28: 125: 21.05
+	Hs
		892578 H2B2E_HUMAN (3-123): 9.57e-49: 153: 82.11		DNLI3_HUMAN (4-107): 1.81e-28: 125: 21.05
+	Hs
		892593 H2B3B_HUMAN (3-123): 1.15e-46: 148: 81.30		DNLI3_HUMAN (4-107): 1.81e-28: 125: 21.05
+	Hs
		486962 H2B1O_HUMAN (3-123): 3.31e-49: 154: 82.11		PARP1_HUMAN (103-513): 5.14e-19: 94.9: 15.74
+	Hs
		487610 H2B1H_HUMAN (3-123): 5.3e-49: 154: 81.30		PARP1_HUMAN (103-513): 5.14e-19: 94.9: 15.74
+	Hs
		487004 H2B1B_HUMAN (3-123): 1.14e-48: 153: 82.11		PARP1_HUMAN (103-513): 5.14e-19: 94.9: 15.74
+	Hs
		487171 H2B1C_HUMAN (3-123): 1.52e-48: 153: 81.30		PARP1_HUMAN (103-513): 5.14e-19: 94.9: 15.74
+	Hs
		487373 H2B2E_HUMAN (3-123): 9.57e-49: 153: 82.11		PARP1_HUMAN (103-513): 5.14e-19: 94.9: 15.74
+	Hs
		1162953 H2B2E_HUMAN (3-123): 9.57e-49: 153: 82.11		PAR10_HUMAN (783-987): 6.68e-19: 94.6: 15.35
+	Hs
		487146 H2B1D_HUMAN (3-123): 2.77e-48: 152: 81.30		PARP1_HUMAN (103-513): 5.14e-19: 94.9: 15.74
+	Hs
		487521 H2B3B_HUMAN (3-123): 1.15e-46: 148: 81.30		PARP1_HUMAN (103-513): 5.14e-19: 94.9: 15.74