Interactor 1: GFRAL (Q6UXV0)
GDNF family receptor alpha-like
Gene: GFRAL
Interactor 2: GDF15 (Q99988)
Growth/differentiation factor 15 (GDF-15) (Macrophage inhibitory cytokine 1) (MIC-1) (NSAID-activated gene 1 protein) (NAG-1) (NSAID-regulated gene 1 protein) (NRG-1) (Placental TGF-beta) (Placental bone morphogenetic protein) (Prostate differentiation factor)
Gene: GDF15
Species: Homo sapiens
Source: intact
Category: Small-scale
Confidence: High
| Method score | Annotation score | Interaction score |
|---|---|---|
| 0.47 | 1.00 | 0.692 |
The method score is based on:
| Property | Details |
|---|---|
| Experiments | 28953886 |
| Identification Methods | surface plasmon resonance, x-ray crystallography |
| Interaction Type | direct interaction |
The annotation score is based on:
| Property | Details |
|---|---|
| Interacting Pfam domains | GDNF~TGF_beta |
| Common GO terms | GO:0002023 - reduction of food intake in response to dietary excess GO:0032099 - negative regulation of appetite GO:0043410 - positive regulation of MAPK cascade GO:0051897 - positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction GO:0160144 - GDF15-GFRAL signaling pathway and 1 others more... |
| Homologous interactions | 1 |
Homologous interactions
Color coding for hit scores 
|
|
|||||||||||||
| + | Dm |   |
|
|||||||||||
Service provided by Combinatics, Japan
Last updated: 15 Jul 2024
