HitPredict

Interactor 1: MAVS (Q7Z434)
Mitochondrial antiviral-signaling protein (MAVS) (CARD adapter inducing interferon beta) (Cardif) (Interferon beta promoter stimulator protein 1) (IPS-1) (Putative NF-kappa-B-activating protein 031N) (Virus-induced-signaling adapter) (VISA)
Gene: MAVS

Interactor 2: DHX58 (Q96C10)
ATP-dependent RNA helicase DHX58 (EC 3.6.4.13) (ATP-dependent helicase LGP2) (Protein D11Lgp2 homolog) (RIG-I-like receptor 3) (RLR-3) (RIG-I-like receptor LGP2) (RLR)
Gene: DHX58

Species: Homo sapiens

Source: innatedb

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	17020950
Identification Methods	anti tag coimmunoprecipitation
Interaction Type	physical association

Property	Details
Interacting Pfam domains	CARD_2~ResIII, CARD_2~RIG-I_C
Common GO terms	GO:0002753 - cytoplasmic pattern recognition receptor signaling pathway GO:0032481 - positive regulation of type I interferon production GO:0140374 - antiviral innate immune response
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 540 Hs			1 678
+	Hs
		1190081 MAVS_HUMAN (1-540): 1.73e-73: 245: 100.00		IFIH1_HUMAN (1-674): 7.37e-119: 381: 40.39
+	Hs
		321911 MAVS_HUMAN (1-540): 1.73e-73: 245: 100.00		RIGI_HUMAN (1-666): 1.75e-101: 333: 29.89
+	Mm
		1246957 MAVS_MOUSE (1-538): 5.1e-46: 170: 47.68		IFIH1_MOUSE (1-674): 1.33e-119: 383: 39.75
+	Mm
		1163146 MAVS_MOUSE (1-538): 5.1e-46: 170: 47.68		RIGI_MOUSE (1-666): 3.84e-103: 337: 28.88
+	Hs
		134100 MAVS_HUMAN (1-540): 1.73e-73: 245: 100.00		DDX3X_HUMAN (146-516): 5.67e-56: 203: 16.67
+	Mm
		1163120 KMT2C_MOUSE (128-523): 8.47e-09: 60.6: 10.33		RIGI_MOUSE (1-666): 3.84e-103: 337: 28.88
+	Hs
		1300971 CIC_HUMAN (40-516): 7.01e-10: 64.1: 12.58		CHD7_HUMAN (2-593): 4.96e-79: 277: 12.36
+	Hs
		229467 CIC_HUMAN (40-516): 7.01e-10: 64.1: 12.58		SMCA5_HUMAN (2-611): 7.74e-78: 270: 12.38
+	Hs
		867130 SC24C_HUMAN (116-429): 9.64e-11: 66.7: 15.43		CHD8_HUMAN (2-605): 2.72e-75: 266: 12.29
+	Hs
		1300950 CIC_HUMAN (40-516): 7.01e-10: 64.1: 12.58		CHD8_HUMAN (2-605): 2.72e-75: 266: 12.29
+	Dm
		55478 RPB1_DROME (131-506): 1.34e-11: 69.8: 12.82		DCR2_DROME (1-562): 2.44e-73: 260: 17.96
+	Dm
		375643 RPB1_DROME (131-506): 1.34e-11: 69.8: 12.82		BRM_DROME (2-577): 7.77e-73: 259: 13.92
+	Hs
		1056830 MDC1_HUMAN (105-516): 3.47e-10: 65.2: 10.48		CHD4_HUMAN (2-626): 2.02e-73: 260: 12.48
+	Hs
		1059794 CHAP1_HUMAN (196-539): 2.7e-10: 65.2: 10.38		CHD4_HUMAN (2-626): 2.02e-73: 260: 12.48
+	Hs
		1059807 CIC_HUMAN (40-516): 7.01e-10: 64.1: 12.58		CHD4_HUMAN (2-626): 2.02e-73: 260: 12.48
+	Hs
		134175 CIC_HUMAN (40-516): 7.01e-10: 64.1: 12.58		DDX3X_HUMAN (146-516): 5.67e-56: 203: 16.67
+	Hs
		1271630 CIC_HUMAN (40-516): 7.01e-10: 64.1: 12.58		DDX17_HUMAN (2-260): 1.9e-42: 165: 17.23
+	Hs
		757666 HUWE1_HUMAN (79-539): 8.05e-24: 108: 13.36		IF4A3_HUMAN (2-345): 5e-28: 118: 8.96
+	Hs
		571557 CIC_HUMAN (40-516): 7.01e-10: 64.1: 12.58		DDX5_HUMAN (2-255): 1.99e-37: 150: 15.21
+	Hs
		757612 MDC1_HUMAN (105-516): 3.47e-10: 65.2: 10.48		IF4A3_HUMAN (2-345): 5e-28: 118: 8.96