HitPredict

Interactor 1: MAVS (Q7Z434)
Mitochondrial antiviral-signaling protein (MAVS) (CARD adapter inducing interferon beta) (Cardif) (Interferon beta promoter stimulator protein 1) (IPS-1) (Putative NF-kappa-B-activating protein 031N) (Virus-induced-signaling adapter) (VISA)
Gene: MAVS

Interactor 2: RN125 (Q96EQ8)
E3 ubiquitin-protein ligase RNF125 (EC 2.3.2.27) (RING finger protein 125) (T-cell RING activation protein 1) (TRAC-1)
Gene: RNF125

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.50	0.437

Property	Details
Experiments	17460044
Identification Methods	anti tag coimmunoprecipitation
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	-
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 540 Hs			1 232
+	Hs
		1190139 MAVS_HUMAN (1-540): 1.73e-73: 245: 100.00		RN114_HUMAN (9-225): 2.79e-44: 150: 29.26
+	Hs
		584997 MAVS_HUMAN (1-540): 1.73e-73: 245: 100.00		RO52_HUMAN (22-227): 1.26e-41: 149: 13.30
+	Hs
		1190047 MAVS_HUMAN (1-540): 1.73e-73: 245: 100.00		RN166_HUMAN (1-224): 1.46e-42: 145: 30.83
+	Hs
		1190083 MAVS_HUMAN (1-540): 1.73e-73: 245: 100.00		TRIM7_HUMAN (9-228): 5.54e-39: 142: 13.58
+	Hs
		1190082 MAVS_HUMAN (1-540): 1.73e-73: 245: 100.00		TRI31_HUMAN (22-226): 5.82e-36: 133: 12.50
+	Hs
		1024700 MAVS_HUMAN (1-540): 1.73e-73: 245: 100.00		TRAF3_HUMAN (5-175): 4.42e-33: 127: 19.89
+	Hs
		129573 MAVS_HUMAN (1-540): 1.73e-73: 245: 100.00		TRAF5_HUMAN (8-176): 3.95e-29: 116: 23.81
+	Hs
		1190136 MAVS_HUMAN (1-540): 1.73e-73: 245: 100.00		TRAF6_HUMAN (6-175): 2.58e-26: 108: 21.39
+	Mm
		1112453 MAVS_MOUSE (1-538): 5.1e-46: 170: 47.68		Q3UCL2_MOUSE (27-227): 1.57e-39: 143: 16.36
+	Mm
		1246776 MAVS_MOUSE (1-538): 5.1e-46: 170: 47.68		TRI31_MOUSE (22-231): 1.51e-31: 122: 14.60
+	Mm
		936210 MAVS_MOUSE (1-538): 5.1e-46: 170: 47.68		TRAF5_MOUSE (8-172): 2.22e-29: 116: 22.83
+	Mm
		1141429 MAVS_MOUSE (1-538): 5.1e-46: 170: 47.68		TRAF3_MOUSE (5-175): 5.08e-29: 115: 18.18
+	Mm
		936265 MAVS_MOUSE (1-538): 5.1e-46: 170: 47.68		TRAF6_MOUSE (6-174): 3.2e-27: 110: 22.67
+	Hs
		585039 CIC_HUMAN (40-516): 7.01e-10: 64.1: 12.58		RO52_HUMAN (22-227): 1.26e-41: 149: 13.30
+	Mm
		1112346 SC24A_MOUSE (93-490): 4.12e-17: 87.2: 16.71		TRAF3_MOUSE (5-175): 5.08e-29: 115: 18.18
+	Hs
		1223389 CIC_HUMAN (40-516): 7.01e-10: 64.1: 12.58		TRI22_HUMAN (30-228): 2.75e-37: 137: 13.49
+	Hs
		537122 MAGL2_HUMAN (48-539): 3.46e-09: 61.8: 10.14		TRI27_HUMAN (22-228): 7.77e-33: 125: 15.49
+	Mm
		101444 F8VPR5_MOUSE (82-395): 1.45e-11: 69.8: 14.24		TRAF3_MOUSE (5-175): 5.08e-29: 115: 18.18
+	Hs
		551440 MDC1_HUMAN (105-516): 3.47e-10: 65.2: 10.48		RAG1_HUMAN (26-140): 1.98e-25: 106: 27.73
+	Hs
		1055155 CIC_HUMAN (40-516): 7.01e-10: 64.1: 12.58		HLTF_HUMAN (4-97): 6.12e-12: 66.7: 24.76