HitPredict

Interactor 1: HDGR2 (Q7Z4V5)
Hepatoma-derived growth factor-related protein 2 (HDGF-related protein 2) (HRP-2) (Hepatoma-derived growth factor 2) (HDGF-2)
Gene: HDGFL2

Interactor 2: H2AW (Q9P0M6)
Core histone macro-H2A.2 (Histone macroH2A2) (mH2A2)
Gene: MACROH2A2

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	1.00	0.691

Property	Details
Experiments	33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	Histone~PWWP
Common GO terms	GO:0005634 - nucleus
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 671 Hs			1 372
+	Hs
		260919 HDGR2_HUMAN (1-671): 9.52e-82: 274: 100.00		H2AY_HUMAN (1-371): 8.19e-156: 444: 66.31
+	Hs
		261003 NSD3_HUMAN (4-413): 2.6e-62: 227: 11.66		H2AY_HUMAN (1-371): 8.19e-156: 444: 66.31
+	Hs
		260680 PSIP1_HUMAN (1-553): 1.35e-54: 197: 23.49		H2AY_HUMAN (1-371): 8.19e-156: 444: 66.31
+	Hs
		260808 MSH6_HUMAN (4-299): 4.35e-45: 175: 12.98		H2AY_HUMAN (1-371): 8.19e-156: 444: 66.31
+	Hs
		261039 ZMYD8_HUMAN (6-605): 7.73e-40: 159: 14.24		H2AY_HUMAN (1-371): 8.19e-156: 444: 66.31
+	Hs
		1349695 ZMYD8_HUMAN (6-605): 7.73e-40: 159: 14.24		H2AW_HUMAN (1-372): 5.27e-152: 434: 100.00
+	Hs
		1115591 GLYR1_HUMAN (6-212): 3.25e-36: 145: 21.10		H2AW_HUMAN (1-372): 5.27e-152: 434: 100.00
+	Hs
		260805 HDGF_HUMAN (3-234): 8.81e-26: 108: 35.78		H2AY_HUMAN (1-371): 8.19e-156: 444: 66.31
+	Hs
		850992 HDGF_HUMAN (3-234): 8.81e-26: 108: 35.78		H2AW_HUMAN (1-372): 5.27e-152: 434: 100.00
+	Hs
		555526 HDGR2_HUMAN (1-671): 9.52e-82: 274: 100.00		H2AX_HUMAN (1-144): 1.72e-66: 208: 57.14
+	Hs
		331860 NSD2_HUMAN (3-440): 5.42e-66: 238: 11.70		H2A1C_HUMAN (1-126): 2.96e-64: 202: 61.24
+	Hs
		331703 NSD2_HUMAN (3-440): 5.42e-66: 238: 11.70		H2A1_HUMAN (1-126): 6.37e-64: 201: 60.47
+	Hs
		331824 NSD2_HUMAN (3-440): 5.42e-66: 238: 11.70		H2A2C_HUMAN (1-126): 7.57e-64: 201: 61.24
+	Mm
		650197 PSIP1_MOUSE (1-553): 5.28e-57: 203: 24.64		H2AX_MOUSE (1-144): 4.61e-65: 204: 56.46
+	Hs
		555365 MSH6_HUMAN (4-299): 4.35e-45: 175: 12.98		H2AX_HUMAN (1-144): 1.72e-66: 208: 57.14
+	Hs
		855539 MSH6_HUMAN (4-299): 4.35e-45: 175: 12.98		H2A1J_HUMAN (1-125): 2.23e-64: 202: 60.94
+	Hs
		555690 ZMYD8_HUMAN (6-605): 7.73e-40: 159: 14.24		H2AX_HUMAN (1-144): 1.72e-66: 208: 57.14
+	Hs
		391965 ZMYD8_HUMAN (6-605): 7.73e-40: 159: 14.24		H2A1B_HUMAN (1-126): 6.65e-64: 201: 60.47
+	Hs
		391730 GLYR1_HUMAN (6-212): 3.25e-36: 145: 21.10		H2A1B_HUMAN (1-126): 6.65e-64: 201: 60.47
+	Hs
		555503 NIPBL_HUMAN (100-662): 1.42e-17: 89.7: 16.10		H2AX_HUMAN (1-144): 1.72e-66: 208: 57.14