HitPredict

Interactor 1: Q80UI5 (Q80UI5)
Phosphatidylinositol 3-kinase, regulatory subunit, polypeptide 1 (P85 alpha) (Phosphoinositide-3-kinase regulatory subunit 1)
Gene: Pik3r1

Interactor 2: GAB1 (Q9QYY0)
GRB2-associated-binding protein 1 (GRB2-associated binder 1) (Growth factor receptor bound protein 2-associated protein 1)
Gene: GAB1

Species: Mus musculus

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.42	0.50	0.462

Property	Details
Experiments	10871282
Identification Methods	two hybrid, anti tag coimmunoprecipitation
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	-
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 454 Mm			1 695
+	Hs
		1035395 P55G_HUMAN (1-453): 1.27e-99: 307: 76.37		GAB1_HUMAN (1-695): 1.08e-115: 364: 90.22
+	Mm
		643113 P85A_MOUSE (58-454): 7.76e-96: 305: 100.00		GAB1_MOUSE (1-695): 2.76e-116: 366: 100.00
+	Hs
		655356 P85A_HUMAN (46-454): 5.13e-96: 306: 99.27		GAB1_HUMAN (1-695): 1.08e-115: 364: 90.22
+	Hs
		129290 P85B_HUMAN (54-449): 8.77e-88: 284: 76.83		GAB1_HUMAN (1-695): 1.08e-115: 364: 90.22
+	Hs
		655510 P85A_HUMAN (46-454): 5.13e-96: 306: 99.27		GAB2_HUMAN (3-692): 1.8e-86: 287: 37.09
+	Hs
		129351 P85B_HUMAN (54-449): 8.77e-88: 284: 76.83		GAB2_HUMAN (3-692): 1.8e-86: 287: 37.09
+	Mm
		643089 P85A_MOUSE (58-454): 7.76e-96: 305: 100.00		Q3ZB59_MOUSE (3-692): 1.55e-74: 255: 36.53
+	Hs
		147519 SOCS6_HUMAN (29-201): 1.43e-31: 128: 23.20		GAB1_HUMAN (1-695): 1.08e-115: 364: 90.22
+	Hs
		846468 BLK_HUMAN (264-454): 3.19e-31: 127: 20.10		GAB1_HUMAN (1-695): 1.08e-115: 364: 90.22
+	Hs
		442825 HCK_HUMAN (301-454): 2.46e-27: 116: 22.84		GAB1_HUMAN (1-695): 1.08e-115: 364: 90.22
+	Hs
		411709 LCK_HUMAN (213-454): 2.26e-26: 113: 19.52		GAB1_HUMAN (1-695): 1.08e-115: 364: 90.22
+	Hs
		433345 YES_HUMAN (300-454): 4e-26: 113: 20.25		GAB1_HUMAN (1-695): 1.08e-115: 364: 90.22
+	Hs
		655524 P85A_HUMAN (46-454): 5.13e-96: 306: 99.27		MYO16_HUMAN (342-673): 2.4e-10: 66.4: 14.93
+	Hs
		412280 FYN_HUMAN (300-454): 1.71e-27: 116: 22.09		GAB3_HUMAN (1-684): 2.99e-53: 195: 26.19
+	Ce
		136804 VAV_CAEEL (46-160): 3.1e-33: 135: 29.31		UNC89_CAEEL (71-531): 5.43e-31: 133: 11.81
+	Hs
		411582 LCK_HUMAN (213-454): 2.26e-26: 113: 19.52		MUC1_HUMAN (176-682): 2.08e-20: 98.8: 10.65
+	Hs
		337335 ABL1_HUMAN (296-453): 1.14e-25: 112: 23.90		MUC1_HUMAN (176-682): 2.08e-20: 98.8: 10.65
+	Hs
		203198 LCK_HUMAN (213-454): 2.26e-26: 113: 19.52		SYNJ1_HUMAN (125-576): 2.41e-18: 92.2: 12.29
+	Hs
		412362 FYN_HUMAN (300-454): 1.71e-27: 116: 22.09		MAGE1_HUMAN (245-640): 2.48e-12: 72.5: 13.57
+	Hs
		412433 FYN_HUMAN (300-454): 1.71e-27: 116: 22.09		MYO16_HUMAN (342-673): 2.4e-10: 66.4: 14.93