HitPredict

Interactor 1: SHAN3 (Q4ACU6)
SH3 and multiple ankyrin repeat domains protein 3 (Shank3) (Proline-rich synapse-associated protein 2) (ProSAP2) (SPANK-2)
Gene: Shank3

Interactor 2: RAP1B (Q99JI6)
Ras-related protein Rap-1b (EC 3.6.5.2) (GTP-binding protein smg p21B)
Gene: RAP1B

Species: Mus musculus

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.41	1.00	0.647

Property	Details
Experiments	31879129
Identification Methods	pull down
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	Ank_2~Ras
Common GO terms	GO:0005886 - plasma membrane GO:0098978 - glutamatergic synapse
Homologous interactions	19

Homologous interactions

Color coding for hit scores

	1 1730 Mm			1 184
+	Mm
		988884 SHAN3_MOUSE (1-1730): 0: 649: 100.00		RAC1_MOUSE (1-184): 1.74e-77: 231: 27.55
+	Mm
		982149 SHAN3_MOUSE (1-1730): 0: 649: 100.00		RAP1A_MOUSE (1-184): 1.03e-69: 211: 95.11
+	Mm
		1193873 SHAN3_MOUSE (1-1730): 0: 649: 100.00		RAB14_MOUSE (4-178): 7.99e-69: 209: 33.52
+	Mm
		1193739 SHAN3_MOUSE (1-1730): 0: 649: 100.00		RASH_MOUSE (1-167): 1.23e-55: 175: 57.49
+	Mm
		993954 SHAN3_MOUSE (1-1730): 0: 649: 100.00		RALA_MOUSE (4-168): 3.44e-54: 172: 51.52
+	Hs
		988324 ANK3_HUMAN (117-358): 5.45e-50: 198: 23.08		RAC1_HUMAN (1-184): 1.74e-77: 231: 27.55
+	Dm
		55863 A1Z9K8_DROME (550-810): 6.42e-60: 230: 29.28		O96692_DROME (1-166): 2.57e-60: 187: 60.24
+	Hs
		376087 ANR50_HUMAN (197-1139): 3.34e-53: 208: 10.76		RASK_HUMAN (1-167): 6.29e-55: 174: 57.49
+	Hs
		374276 ANR50_HUMAN (197-1139): 3.34e-53: 208: 10.76		RASN_HUMAN (1-167): 5.05e-54: 171: 56.89
+	Hs
		920420 DAPK1_HUMAN (2-202): 2.33e-39: 163: 15.20		RB11A_HUMAN (4-178): 2.13e-69: 211: 28.98
+	Hs
		375464 ANK3_HUMAN (117-358): 5.45e-50: 198: 23.08		RASK_HUMAN (1-167): 6.29e-55: 174: 57.49
+	Hs
		988289 ANK2_HUMAN (212-349): 4.61e-29: 129: 24.64		RAC1_HUMAN (1-184): 1.74e-77: 231: 27.55
+	Hs
		988816 KDIS_HUMAN (258-532): 5.17e-28: 126: 12.36		RAC1_HUMAN (1-184): 1.74e-77: 231: 27.55
+	Hs
		374490 DAPK1_HUMAN (2-202): 2.33e-39: 163: 15.20		RASH_HUMAN (1-167): 1.23e-55: 175: 57.49
+	Hs
		976655 KDIS_HUMAN (258-532): 5.17e-28: 126: 12.36		RB11A_HUMAN (4-178): 2.13e-69: 211: 28.98
+	Hs
		374532 ANK2_HUMAN (212-349): 4.61e-29: 129: 24.64		RASH_HUMAN (1-167): 1.23e-55: 175: 57.49
+	Hs
		375418 ANK2_HUMAN (212-349): 4.61e-29: 129: 24.64		RASK_HUMAN (1-167): 6.29e-55: 174: 57.49
+	Hs
		376086 KDIS_HUMAN (258-532): 5.17e-28: 126: 12.36		RASK_HUMAN (1-167): 6.29e-55: 174: 57.49
+	Hs
		374275 KDIS_HUMAN (258-532): 5.17e-28: 126: 12.36		RASN_HUMAN (1-167): 5.05e-54: 171: 56.89