HitPredict

Interactor 1: PCGF5 (Q86SE9)
Polycomb group RING finger protein 5 (RING finger protein 159)
Gene: PCGF5

Interactor 2: RYBP (Q8N488)
RING1 and YY1-binding protein (Apoptin-associating protein 1) (APAP-1) (Death effector domain-associated factor) (DED-associated factor) (YY1 and E4TF1-associated factor 1)
Gene: RYBP

Species: Homo sapiens

Source: mint

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.93	1.00	0.965

Property	Details
Experiments	26186194, 28514442, 27705803, 33961781, 22325352, 24981860, 34316702
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation, tandem affinity purification, anti bait coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	RAWUL~YAF2_RYBP
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0031519 - PcG protein complex GO:0046872 - metal ion binding
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 256 Hs			1 228
+	Hs
		585013 RO52_HUMAN (3-242): 5.86e-56: 187: 13.79		RYBP_HUMAN (1-228): 2.79e-61: 193: 100.00
+	Hs
		718013 BMI1_HUMAN (1-229): 2.24e-57: 187: 30.38		RYBP_HUMAN (1-228): 2.79e-61: 193: 100.00
+	Hs
		718410 PCGF2_HUMAN (1-244): 2.94e-56: 185: 29.13		RYBP_HUMAN (1-228): 2.79e-61: 193: 100.00
+	Hs
		1197569 PCGF5_HUMAN (1-256): 3.16e-62: 197: 100.00		YAF2_HUMAN (3-227): 3.24e-55: 176: 52.89
+	Mm
		620789 PCGF2_MOUSE (1-244): 1.85e-53: 177: 28.35		RYBP_MOUSE (1-228): 1.71e-61: 193: 99.12
+	Hs
		718000 BMI1_HUMAN (1-229): 2.24e-57: 187: 30.38		YAF2_HUMAN (3-227): 3.24e-55: 176: 52.89
+	Hs
		718409 PCGF2_HUMAN (1-244): 2.94e-56: 185: 29.13		YAF2_HUMAN (3-227): 3.24e-55: 176: 52.89
+	Hs
		1108517 PCGF3_HUMAN (3-255): 1.23e-48: 162: 37.04		RYBP_HUMAN (1-228): 2.79e-61: 193: 100.00
+	Hs
		1233190 PCGF6_HUMAN (4-248): 2.54e-43: 151: 32.25		RYBP_HUMAN (1-228): 2.79e-61: 193: 100.00
+	Mm
		1208119 PCGF1_MOUSE (4-232): 6.96e-43: 148: 31.49		RYBP_MOUSE (1-228): 1.71e-61: 193: 99.12
+	Mm
		1208123 RING2_MOUSE (2-252): 2.64e-41: 146: 17.59		RYBP_MOUSE (1-228): 1.71e-61: 193: 99.12
+	Hs
		1233178 PCGF1_HUMAN (4-232): 3.33e-42: 146: 31.06		RYBP_HUMAN (1-228): 2.79e-61: 193: 100.00
+	Hs
		1108516 PCGF3_HUMAN (3-255): 1.23e-48: 162: 37.04		YAF2_HUMAN (3-227): 3.24e-55: 176: 52.89
+	Hs
		1019331 TRI26_HUMAN (3-235): 3.17e-43: 155: 15.19		YAF2_HUMAN (3-227): 3.24e-55: 176: 52.89
+	Mm
		1307837 RING2_MOUSE (2-252): 2.64e-41: 146: 17.59		YAF2_MOUSE (3-227): 5.87e-58: 183: 54.67
+	Hs
		1222219 PCGF6_HUMAN (4-248): 2.54e-43: 151: 32.25		YAF2_HUMAN (3-227): 3.24e-55: 176: 52.89
+	Hs
		1222217 PCGF1_HUMAN (4-232): 3.33e-42: 146: 31.06		YAF2_HUMAN (3-227): 3.24e-55: 176: 52.89
+	Dm
		627173 SUZ2_DROME (9-226): 2.21e-46: 167: 26.13		Q9W215_DROME (3-197): 3.06e-42: 142: 37.95
+	Dm
		728817 PSC_DROME (2-252): 3.97e-46: 166: 25.39		Q9W215_DROME (3-197): 3.06e-42: 142: 37.95
+	Dm
		1374687 Q9VV77_DROME (3-222): 1.49e-44: 151: 41.26		Q9W215_DROME (3-197): 3.06e-42: 142: 37.95