HitPredict

Interactor 1: PCGF5 (Q86SE9)
Polycomb group RING finger protein 5 (RING finger protein 159)
Gene: PCGF5

Interactor 2: CBX8 (Q9HC52)
Chromobox protein homolog 8 (Polycomb 3 homolog) (Pc3) (hPc3) (Rectachrome 1)
Gene: CBX8

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.83	1.00	0.914

Property	Details
Experiments	26496610, 27705803, 24981860, 21282530
Identification Methods	affinity chromatography technology, pull down, anti tag coimmunoprecipitation, tandem affinity purification
Interaction Type	physical association, direct interaction, association

Property	Details
Interacting Pfam domains	CBX7_C~RAWUL
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0031519 - PcG protein complex GO:0035102 - PRC1 complex
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 256 Hs			1 389
+	Hs
		718213 BMI1_HUMAN (1-229): 2.24e-57: 187: 30.38		CBX8_HUMAN (1-389): 5.01e-104: 314: 100.00
+	Mm
		639481 BMI1_MOUSE (1-229): 1.41e-56: 185: 30.21		CBX8_MOUSE (1-389): 2.38e-101: 306: 84.58
+	Hs
		316077 PCGF5_HUMAN (1-256): 3.16e-62: 197: 100.00		CBX6_HUMAN (1-386): 1.08e-65: 216: 33.26
+	Hs
		123273 PCGF5_HUMAN (1-256): 3.16e-62: 197: 100.00		CBX4_HUMAN (1-349): 3.84e-62: 210: 21.93
+	Hs
		315976 BMI1_HUMAN (1-229): 2.24e-57: 187: 30.38		CBX6_HUMAN (1-386): 1.08e-65: 216: 33.26
+	Hs
		315977 PCGF2_HUMAN (1-244): 2.94e-56: 185: 29.13		CBX6_HUMAN (1-386): 1.08e-65: 216: 33.26
+	Hs
		123174 RO52_HUMAN (3-242): 5.86e-56: 187: 13.79		CBX4_HUMAN (1-349): 3.84e-62: 210: 21.93
+	Hs
		123193 BMI1_HUMAN (1-229): 2.24e-57: 187: 30.38		CBX4_HUMAN (1-349): 3.84e-62: 210: 21.93
+	Hs
		123194 PCGF2_HUMAN (1-244): 2.94e-56: 185: 29.13		CBX4_HUMAN (1-349): 3.84e-62: 210: 21.93
+	Hs
		718131 BMI1_HUMAN (1-229): 2.24e-57: 187: 30.38		MPP8_HUMAN (6-356): 2.27e-52: 188: 18.85
+	Hs
		1059168 PCGF5_HUMAN (1-256): 3.16e-62: 197: 100.00		CBX2_HUMAN (2-348): 3.75e-46: 167: 22.03
+	Dr
		1186372 BMI1B_DANRE (1-230): 1.36e-57: 188: 28.69		Q804D1_DANRE (1-249): 1.15e-47: 170: 26.91
+	Hs
		717831 BMI1_HUMAN (1-229): 2.24e-57: 187: 30.38		CBX2_HUMAN (2-348): 3.75e-46: 167: 22.03
+	Mm
		639466 BMI1_MOUSE (1-229): 1.41e-56: 185: 30.21		CBX2_MOUSE (2-335): 3.31e-46: 167: 21.11
+	Hs
		327851 PCGF5_HUMAN (1-256): 3.16e-62: 197: 100.00		CBX7_HUMAN (1-235): 2.71e-41: 147: 28.46
+	Hs
		327830 BMI1_HUMAN (1-229): 2.24e-57: 187: 30.38		CBX7_HUMAN (1-235): 2.71e-41: 147: 28.46
+	Hs
		327831 PCGF2_HUMAN (1-244): 2.94e-56: 185: 29.13		CBX7_HUMAN (1-235): 2.71e-41: 147: 28.46
+	Hs
		1027092 PCGF5_HUMAN (1-256): 3.16e-62: 197: 100.00		CBX3_HUMAN (9-144): 1.3e-26: 106: 25.74
+	Hs
		717776 BMI1_HUMAN (1-229): 2.24e-57: 187: 30.38		CBX3_HUMAN (9-144): 1.3e-26: 106: 25.74
+	Hs
		717529 BMI1_HUMAN (1-229): 2.24e-57: 187: 30.38		CBX5_HUMAN (11-144): 1.06e-25: 104: 25.00