HitPredict

Interactor 1: PCGF5 (Q86SE9)
Polycomb group RING finger protein 5 (RING finger protein 159)
Gene: PCGF5

Interactor 2: YAF2 (Q8IY57)
YY1-associated factor 2
Gene: YAF2

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.92	1.00	0.963

Property	Details
Experiments	26186194, 28514442, 27705803, 24981860, 33961781, 22325352, 27684187
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation, tandem affinity purification
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	RAWUL~YAF2_RYBP
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0046872 - metal ion binding
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 256 Hs			1 180
+	Hs
		718000 BMI1_HUMAN (1-229): 2.24e-57: 187: 30.38		YAF2_HUMAN (1-180): 8.51e-73: 218: 100.00
+	Hs
		718409 PCGF2_HUMAN (1-244): 2.94e-56: 185: 29.13		YAF2_HUMAN (1-180): 8.51e-73: 218: 100.00
+	Hs
		1108516 PCGF3_HUMAN (3-255): 1.23e-48: 162: 37.04		YAF2_HUMAN (1-180): 8.51e-73: 218: 100.00
+	Hs
		1019331 TRI26_HUMAN (3-235): 3.17e-43: 155: 15.19		YAF2_HUMAN (1-180): 8.51e-73: 218: 100.00
+	Mm
		1307837 RING2_MOUSE (2-252): 2.64e-41: 146: 17.59		YAF2_MOUSE (1-180): 3.8e-76: 227: 91.67
+	Hs
		1222219 PCGF6_HUMAN (4-248): 2.54e-43: 151: 32.25		YAF2_HUMAN (1-180): 8.51e-73: 218: 100.00
+	Hs
		1222217 PCGF1_HUMAN (4-232): 3.33e-42: 146: 31.06		YAF2_HUMAN (1-180): 8.51e-73: 218: 100.00
+	Hs
		1197570 PCGF5_HUMAN (1-256): 3.16e-62: 197: 100.00		RYBP_HUMAN (1-179): 5.8e-49: 160: 49.78
+	Hs
		585013 RO52_HUMAN (3-242): 5.86e-56: 187: 13.79		RYBP_HUMAN (1-179): 5.8e-49: 160: 49.78
+	Hs
		718013 BMI1_HUMAN (1-229): 2.24e-57: 187: 30.38		RYBP_HUMAN (1-179): 5.8e-49: 160: 49.78
+	Hs
		718410 PCGF2_HUMAN (1-244): 2.94e-56: 185: 29.13		RYBP_HUMAN (1-179): 5.8e-49: 160: 49.78
+	Mm
		620789 PCGF2_MOUSE (1-244): 1.85e-53: 177: 28.35		RYBP_MOUSE (1-179): 3.52e-49: 160: 49.78
+	Dm
		627173 SUZ2_DROME (9-226): 2.21e-46: 167: 26.13		Q9W215_DROME (1-133): 1.35e-51: 163: 51.13
+	Dm
		728817 PSC_DROME (2-252): 3.97e-46: 166: 25.39		Q9W215_DROME (1-133): 1.35e-51: 163: 51.13
+	Hs
		1108517 PCGF3_HUMAN (3-255): 1.23e-48: 162: 37.04		RYBP_HUMAN (1-179): 5.8e-49: 160: 49.78
+	Dm
		1374687 Q9VV77_DROME (3-222): 1.49e-44: 151: 41.26		Q9W215_DROME (1-133): 1.35e-51: 163: 51.13
+	Hs
		1233190 PCGF6_HUMAN (4-248): 2.54e-43: 151: 32.25		RYBP_HUMAN (1-179): 5.8e-49: 160: 49.78
+	Mm
		1208119 PCGF1_MOUSE (4-232): 6.96e-43: 148: 31.49		RYBP_MOUSE (1-179): 3.52e-49: 160: 49.78
+	Mm
		1208123 RING2_MOUSE (2-252): 2.64e-41: 146: 17.59		RYBP_MOUSE (1-179): 3.52e-49: 160: 49.78
+	Hs
		1233178 PCGF1_HUMAN (4-232): 3.33e-42: 146: 31.06		RYBP_HUMAN (1-179): 5.8e-49: 160: 49.78