HitPredict

Interactor 1: SETMR (Q53H47)
Histone-lysine N-methyltransferase SETMAR (SET domain and mariner transposase fusion protein) (Metnase) [Includes: Histone-lysine N-methyltransferase (EC 2.1.1.357); Transposon Hsmar1 transposase (EC 3.1.-.-)]
Gene: SETMAR

Interactor 2: SETMR (Q53H47)
Histone-lysine N-methyltransferase SETMAR (SET domain and mariner transposase fusion protein) (Metnase) [Includes: Histone-lysine N-methyltransferase (EC 2.1.1.357); Transposon Hsmar1 transposase (EC 3.1.-.-)]
Gene: SETMAR

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.72 1.00 0.850

The method score is based on:

Property Details
Experiments 16169070, 18263876, 20416268
Identification Methods two hybrid, affinity chromatography technology, two hybrid pooling approach
Interaction Type direct interaction, physical association

The annotation score is based on:

Property Details
Interacting Pfam domains HTH_48~HTH_48, Pre-SET~Pre-SET, Pre-SET~SET
Common GO terms GO:0000014 - single-stranded DNA endodeoxyribonuclease activity
GO:0000729 - DNA double-strand break processing
GO:0003677 - DNA binding
GO:0003690 - double-stranded DNA binding
GO:0003697 - single-stranded DNA binding
and 21 others

more...
Homologous interactions 14

Homologous interactions

Color coding for hit scores

1 684
Hs

1 684
+ Mm
+ Hs
+ Hs
+ Hs
+ Mm
+ Hs
+ Hs
+ Dm
+ Hs
+ Hs
+ Hs
+ Hs
+ Sp
+ Zm

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Last updated: 11Aug2025