HitPredict

Interactor 1: Q5BI50 (Q5BI50)
Cullin-4A
Gene: Cul4

Interactor 2: RBX1A (Q9W5E1)
RING-box protein 1A (Regulator of cullins 1a) (dRbx1)
Gene: Roc1a

Species: Drosophila melanogaster

Source: biogrid

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.38 1.00 0.618

The method score is based on:

Property Details
Experiments 18698375
Identification Methods affinity chromatography technology
Interaction Type physical association

The annotation score is based on:

Property Details
Interacting Pfam domains Cullin~zf-rbx1, Cullin_Nedd8~zf-rbx1
Common GO terms GO:0005634 - nucleus
GO:0006511 - ubiquitin-dependent protein catabolic process
GO:0016567 - protein ubiquitination
GO:0045879 - negative regulation of smoothened signaling pathway
GO:0080008 - Cul4-RING E3 ubiquitin ligase complex
Homologous interactions 20

Homologous interactions (Top 20)

Color coding for hit scores

1 821
Dm

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Last updated: 11Aug2025