HitPredict

Interactor 1: TCAM2 (Q86XR7)
TIR domain-containing adapter molecule 2 (TICAM-2) (Putative NF-kappa-B-activating protein 502) (TRIF-related adapter molecule) (Toll-like receptor adaptor protein 3) (Toll/interleukin-1 receptor domain-containing protein) (MyD88-4)
Gene: TICAM2

Interactor 2: TRAF6 (Q9Y4K3)
TNF receptor-associated factor 6 (EC 2.3.2.27) (E3 ubiquitin-protein ligase TRAF6) (Interleukin-1 signal transducer) (RING finger protein 85) (RING-type E3 ubiquitin transferase TRAF6)
Gene: TRAF6

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.69 0.60 0.646

The method score is based on:

Property Details
Experiments 24812060, 12721283
Identification Methods affinity chromatography technology, pull down, coimmunoprecipitation
Interaction Type physical association, direct interaction

The annotation score is based on:

Property Details
Interacting Pfam domains -
Common GO terms GO:0005886 - plasma membrane
GO:0010008 - endosome membrane
GO:0031663 - lipopolysaccharide-mediated signaling pathway
GO:0032481 - positive regulation of type I interferon production
GO:0034142 - toll-like receptor 4 signaling pathway
and 4 others

more...
Homologous interactions 11

Homologous interactions

Color coding for hit scores

1 235
Hs

1 522
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Service provided by Combinatics, Japan

Last updated: 15 Jul 2024