HitPredict

Interactor 1: PSD12 (O00232)
26S proteasome non-ATPase regulatory subunit 12 (26S proteasome regulatory subunit RPN5) (26S proteasome regulatory subunit p55)
Gene: PSMD12

Interactor 2: RD23B (P54727)
UV excision repair protein RAD23 homolog B (HR23B) (hHR23B) (XP-C repair-complementing complex 58 kDa protein) (p58)
Gene: RAD23B

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.56	0.60	0.584

Property	Details
Experiments	27114451, 20890303
Identification Methods	affinity chromatography technology, pull down
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000502 - proteasome complex GO:0005654 - nucleoplasm GO:0005829 - cytosol GO:0043161 - proteasome-mediated ubiquitin-dependent protein catabolic process
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 456 Hs			1 409
+	Rn
		1117326 Q5XIC6_RAT (1-456): 1.36e-154: 448: 98.03		RD23B_RAT (1-409): 1.14e-120: 358: 87.23
+	Hs
		121972 PSD12_HUMAN (1-456): 2.11e-155: 449: 100.00		RD23A_HUMAN (1-409): 9.12e-94: 287: 56.72
+	Hs
		121715 PSD11_HUMAN (27-443): 9.3e-90: 281: 15.44		RD23B_HUMAN (1-409): 1.31e-125: 370: 100.00
+	Hs
		122104 PSD12_HUMAN (1-456): 2.11e-155: 449: 100.00		UBQL1_HUMAN (1-404): 1.25e-57: 200: 13.72
+	Rn
		78168 B5DEP6_RAT (27-443): 4.36e-90: 282: 15.44		RD23B_RAT (1-409): 1.14e-120: 358: 87.23
+	Hs
		122100 PSD12_HUMAN (1-456): 2.11e-155: 449: 100.00		UBQL2_HUMAN (1-364): 5.93e-51: 182: 13.68
+	Hs
		122095 PSD12_HUMAN (1-456): 2.11e-155: 449: 100.00		UBQL4_HUMAN (1-364): 2.75e-45: 166: 12.71
+	Mm
		477004 PSD12_MOUSE (1-456): 2.1e-154: 447: 97.59		UBC_MOUSE (1-118): 1.78e-32: 131: 21.67
+	Hs
		121988 PSD12_HUMAN (1-456): 2.11e-155: 449: 100.00		RL40_HUMAN (1-91): 3.57e-33: 122: 28.57
+	Hs
		121714 PSD11_HUMAN (27-443): 9.3e-90: 281: 15.44		RD23A_HUMAN (1-409): 9.12e-94: 287: 56.72
+	Sc
		697126 RPN5_YEAST (14-456): 3.37e-106: 324: 40.67		RAD23_YEAST (1-407): 2.12e-72: 233: 28.41
+	Dm
		1359379 Q9V3Z4_DROME (11-455): 4.84e-121: 364: 46.67		Q9VWD9_DROME (1-353): 1.07e-44: 164: 11.08
+	Hs
		121987 PSD12_HUMAN (1-456): 2.11e-155: 449: 100.00		RS27A_HUMAN (1-90): 2.4e-15: 75: 26.67
+	Hs
		1311916 CSN4_HUMAN (45-448): 2.23e-100: 307: 19.37		UBQL1_HUMAN (1-404): 1.25e-57: 200: 13.72
+	At
		1092027 PS12A_ARATH (34-454): 1.75e-126: 376: 43.02		UBQ3_ARATH (1-80): 7.66e-29: 116: 28.75
+	At
		1091832 PS12B_ARATH (34-455): 7.68e-123: 366: 43.37		UBQ3_ARATH (1-80): 7.66e-29: 116: 28.75
+	Mm
		291853 CSN4_MOUSE (45-448): 1.94e-100: 307: 19.37		UBC_MOUSE (1-118): 1.78e-32: 131: 21.67
+	Mm
		476740 CSN2_MOUSE (24-439): 1.11e-94: 294: 12.59		UBC_MOUSE (1-118): 1.78e-32: 131: 21.67
+	At
		1092149 PSD11_ARATH (27-442): 4.61e-90: 281: 16.40		UBQ3_ARATH (1-80): 7.66e-29: 116: 28.75
+	Hs
		121730 PSD11_HUMAN (27-443): 9.3e-90: 281: 15.44		RS27A_HUMAN (1-90): 2.4e-15: 75: 26.67