HitPredict

Interactor 1: PHC2 (Q8IXK0)
Polyhomeotic-like protein 2 (hPH2) (Early development regulatory protein 2)
Gene: PHC2

Interactor 2: HDAC2 (Q92769)
Histone deacetylase 2 (HD2) (EC 3.5.1.98) (Protein deacylase HDAC2) (EC 3.5.1.-)
Gene: HDAC2

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	22325352
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0003682 - chromatin binding GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0042393 - histone binding GO:0045892 - negative regulation of DNA-templated transcription
Homologous interactions	12

Homologous interactions

Color coding for hit scores

	1 858 Hs			1 488
+	Hs
		943080 PHC1_HUMAN (44-858): 3.94e-44: 174: 26.40		HDAC2_HUMAN (1-488): 0: 707: 100.00
+	Hs
		1270377 LMBL3_HUMAN (511-858): 3.47e-35: 145: 17.91		HDAC2_HUMAN (1-488): 0: 707: 100.00
+	Hs
		1270507 SMBT1_HUMAN (448-856): 9.84e-34: 141: 16.96		HDAC2_HUMAN (1-488): 0: 707: 100.00
+	Hs
		1038627 LMBL3_HUMAN (511-858): 3.47e-35: 145: 17.91		HDAC1_HUMAN (1-443): 0: 642: 90.07
+	Hs
		1038787 SMBT1_HUMAN (448-856): 9.84e-34: 141: 16.96		HDAC1_HUMAN (1-443): 0: 642: 90.07
+	Hs
		203227 SYNJ1_HUMAN (4-447): 1.1e-12: 74.2: 12.16		HDAC1_HUMAN (1-443): 0: 642: 90.07
+	Hs
		1056969 MDC1_HUMAN (77-798): 4.5e-17: 88.8: 10.12		HDAC8_HUMAN (33-372): 1.01e-137: 403: 43.40
+	Mm
		88461 D3Z656_MOUSE (362-798): 2.23e-12: 73.4: 10.98		HDAC4_MOUSE (1-377): 6.12e-133: 412: 23.89
+	Mm
		1157748 SYNJ1_MOUSE (297-795): 7.86e-12: 71.5: 9.90		HDAC4_MOUSE (1-377): 6.12e-133: 412: 23.89
+	Mm
		1000158 CHD8_MOUSE (294-790): 5.84e-09: 62.3: 9.13		HDAC4_MOUSE (1-377): 6.12e-133: 412: 23.89
+	Hs
		1220862 PHC2_HUMAN (1-858): 9.36e-98: 326: 100.00		HDAC7_HUMAN (29-280): 1.96e-23: 106: 26.37
+	Hs
		81917 B7ZLY0_HUMAN (1-858): 4.39e-87: 296: 96.39		HDAC7_HUMAN (29-280): 1.96e-23: 106: 26.37