Protein: PIAS3
E3 SUMO-protein ligase PIAS3 (EC 2.3.2.-) (E3 SUMO-protein transferase PIAS3) (Protein inhibitor of activated STAT protein 3)

Gene: PIAS3
Organism: Homo sapiens
Interactions: 84
UniProt ID: Q9Y6X2

Gene Ontology (top 5):
GO:0000122 - negative regulation of transcription by RNA polymerase II
GO:0003712 - transcription coregulator activity
GO:0005654 - nucleoplasm
GO:0005737 - cytoplasm
GO:0006357 - regulation of transcription by RNA polymerase II

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

928241

SUMO1
Small ubiquitin-related modifier 1

4

20

Small-scale

0.888

High

930481

UBC9
SUMO-conjugating enzyme UBC9

2

14

High-throughput

0.791

High

902827

SUMO2
Small ubiquitin-related modifier 2

2

20

Small-scale

0.786

High

1244112

ZMIZ2
Zinc finger MIZ domain-containing protein 2

1

9

Small-scale

0.740

High

776871

STAT3
Signal transducer and activator of transcription 3

7

4

Small-scale

0.737

High

978956

TF65
Transcription factor p65

3

7

Small-scale

0.672

High

879167

SUMO3
Small ubiquitin-related modifier 3

1

20

Small-scale

0.647

High

537154

TRI27
Zinc finger protein RFP

2

7

Small-scale

0.643

High

252940

MITF
Microphthalmia-associated transcription factor

2

6

Small-scale

0.636

High

1356901

ZMIZ1
Zinc finger MIZ domain-containing protein 1

1

9

Small-scale

0.621

High

967015

SATB1
DNA-binding protein SATB1

2

4

Small-scale

0.595

High

1270855

CBP
CREB-binding protein

2

8

Small-scale

0.586

High

1305612

GFI1
Zinc finger protein Gfi-1

1

2

Small-scale

0.586

High

669118

PML
Protein PML

2

7

High-throughput

0.584

High

1270069

ESR2
Estrogen receptor beta

2

20

Small-scale

0.584

High

214435

SPOP
Speckle-type POZ protein

2

3

Small-scale

0.584

High

238214

PLIN3
Perilipin-3

2

0

High-throughput

0.580

High

950349

SMAD3
Mothers against decapentaplegic homolog 3

1

16

Small-scale

0.561

High

1035653

SMAD4
Mothers against decapentaplegic homolog 4

1

16

Small-scale

0.561

High

1078712

SMAD2
Mothers against decapentaplegic homolog 2

1

16

Small-scale

0.561

High

925780

RAC1
Ras-related C3 botulinum toxin substrate 1

1

0

Small-scale

0.554

High

884119

GEMI4
Gem-associated protein 4

2

0

Small-scale

0.551

High

1080574

ZFHX3
Zinc finger homeobox protein 3

1

0

Small-scale

0.549

High

178999

FOXP2
Forkhead box protein P2

1

2

High-throughput

0.541

High

507536

ERG
Transcriptional regulator ERG

1

14

High-throughput

0.541

High

543091

GLNA
Glutamine synthetase

1

2

High-throughput

0.541

High

819691

NRIP1
Nuclear receptor-interacting protein 1

1

1

High-throughput

0.541

High

1016123

SRBP2
Sterol regulatory element-binding protein 2

1

13

High-throughput

0.541

High

1049452

MORC3
MORC family CW-type zinc finger protein 3

1

1

High-throughput

0.541

High

1355892

MBD1
Methyl-CpG-binding domain protein 1

1

2

Small-scale

0.529

High

857520

HMGA2
High mobility group protein HMGI-C

1

0

Small-scale

0.529

High

904210

HNRPK
Heterogeneous nuclear ribonucleoprotein K

1

2

Small-scale

0.515

High

566514

KPCA
Protein kinase C alpha type

1

4

High-throughput

0.515

High

905327

1433G
14-3-3 protein gamma

1

3

High-throughput

0.515

High

1065770

SETB1
Histone-lysine N-methyltransferase SETDB1

1

5

High-throughput

0.515

High

263891

PR40A
Pre-mRNA-processing factor 40 homolog A

1

6

High-throughput

0.508

High

521414

SKIL
Ski-like protein

1

2

High-throughput

0.508

High

607197

UBA1
Ubiquitin-like modifier-activating enzyme 1

1

1

High-throughput

0.508

High

906221

PP1A
Serine/threonine-protein phosphatase PP1-alpha catalytic subunit

1

4

Small-scale

0.508

High

199158

SIAH2
E3 ubiquitin-protein ligase SIAH2

1

8

Small-scale

0.501

High

208800

SNAI2
Zinc finger protein SNAI2

1

3

Small-scale

0.501

High

1023368

TRI32
E3 ubiquitin-protein ligase TRIM32

1

11

Small-scale

0.501

High

1216744

SIAH1
E3 ubiquitin-protein ligase SIAH1

1

8

Small-scale

0.501

High

1251103

SNIP1
Smad nuclear-interacting protein 1

1

3

Small-scale

0.501

High

1251502

LMO3
LIM domain only protein 3

1

0

High-throughput

0.493

High

1273551

KAT5
Histone acetyltransferase KAT5

1

0

High-throughput

0.493

High

906960

PRS4
26S proteasome regulatory subunit 4

1

0

High-throughput

0.486

High

1377430

CHSP1
Calcium-regulated heat-stable protein 1

1

0

High-throughput

0.486

High

487883

ANDR
Androgen receptor

1

20

Small-scale

0.481

High

724032

CBS
Cystathionine beta-synthase

1

2

Small-scale

0.481

High

974418

CREM
cAMP-responsive element modulator

1

3

High-throughput

0.481

High

1128566

HABP4
Intracellular hyaluronan-binding protein 4

1

3

Small-scale

0.481

High

1241095

SERB1
SERPINE1 mRNA-binding protein 1

1

3

Small-scale

0.481

High

1282085

TRI63
E3 ubiquitin-protein ligase TRIM63

1

16

High-throughput

0.481

High

1317554

TRI55
Tripartite motif-containing protein 55

1

15

High-throughput

0.481

High

1349834

SENP1
Sentrin-specific protease 1

1

2

Small-scale

0.481

High

206981

SMAD6
Mothers against decapentaplegic homolog 6

1

16

Small-scale

0.479

High

370843

ESR1
Estrogen receptor

1

20

Small-scale

0.479

High

376356

ANXA1
Annexin A1

1

1

Small-scale

0.479

High

387826

P53
Cellular tumor antigen p53

1

10

High-throughput

0.479

High

414536

PRGR
Progesterone receptor

1

20

Small-scale

0.479

High

507595

PIM1
Serine/threonine-protein kinase pim-1

1

4

Small-scale

0.479

High

611538

NR4A1
Nuclear receptor subfamily 4immunitygroup A member 1

1

16

Small-scale

0.479

High

782840

CSK
Tyrosine-protein kinase CSK

1

2

Small-scale

0.479

High

941645

RNF4
E3 ubiquitin-protein ligase RNF4

1

4

High-throughput

0.479

High

999269

EP300
Histone acetyltransferase p300

1

10

Small-scale

0.479

High

1019197

TP53B
TP53-binding protein 1

1

4

High-throughput

0.479

High

1054238

BECN1
Beclin-1

1

1

Small-scale

0.479

High

1071035

ERBB4
Receptor tyrosine-protein kinase erbB-4

1

1

Small-scale

0.479

High

1222664

SLX4
Structure-specific endonuclease subunit SLX4

1

8

High-throughput

0.479

High

1318360

TRIM8
E3 ubiquitin-protein ligase TRIM8

1

15

Small-scale

0.479

High

1334888

SMUF2
E3 ubiquitin-protein ligase SMURF2

1

3

Small-scale

0.479

High

1348542

TAB2
TGF-beta-activated kinase 1 and MAP3K7-binding protein 2

1

2

Small-scale

0.479

High

1298956

MUS81
Crossover junction endonuclease MUS81

1

0

Small-scale

0.458

High

1328485

BC11A
B-cell lymphoma/leukemia 11A

1

0

Small-scale

0.458

High

1345819

RN146
E3 ubiquitin-protein ligase RNF146

1

0

Small-scale

0.458

High

131293

BIN1
Myc box-dependent-interacting protein 1

1

2

High-throughput

0.457

High

361548

APOE
Apolipoprotein E

1

2

High-throughput

0.457

High

989223

FMR1
Fragile X messenger ribonucleoprotein 1

1

2

High-throughput

0.457

High

1167144

MCAF1
Activating transcription factor 7-interacting protein 1

1

3

High-throughput

0.457

High

1075404

NCOA2
Nuclear receptor coactivator 2

1

7

Small-scale

0.445

High

1356302

ZPI
Protein Z-dependent protease inhibitor

1

1

High-throughput

0.439

High

1290019

REX1B
Required for excision 1-B domain-containing protein

1

0

High-throughput

0.265

Low

1288114

OTUB2
Ubiquitin thioesterase OTUB2

1

0

Small-scale

0.249

Low


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Last updated: 15 Jul 2024