HitPredict

Interactor 1: DLG4 (Q62108)
Disks large homolog 4 (Postsynaptic density protein 95) (PSD-95) (Synapse-associated protein 90) (SAP-90) (SAP90)
Gene: DLG4

Interactor 2: LRFN2 (Q80TG9)
Leucine-rich repeat and fibronectin type-III domain-containing protein 2
Gene: LRFN2

Species: Mus musculus

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.74	1.00	0.866

Property	Details
Experiments	16828986, 28604739, 16495444
Identification Methods	affinity chromatography technology, pull down, anti tag coimmunoprecipitation, anti bait coimmunoprecipitation
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	PDZ~fn3
Common GO terms	GO:0045211 - postsynaptic membrane GO:0098794 - postsynapse
Homologous interactions	17

Homologous interactions

Color coding for hit scores

	1 724 Mm			1 788
+	Rn
		723879 DLG4_RAT (1-724): 0: 654: 99.45		LRFN2_RAT (1-788): 1.59e-160: 487: 98.86
+	Rn
		1192937 DLG3_RAT (20-724): 0: 571: 62.87		LRFN2_RAT (1-788): 1.59e-160: 487: 98.86
+	Mm
		999790 DLG3_MOUSE (20-724): 0: 571: 62.87		LRFN2_MOUSE (1-788): 1.77e-160: 487: 100.00
+	Mm
		1281877 DLG1_MOUSE (5-724): 0: 561: 68.98		LRFN2_MOUSE (1-788): 1.77e-160: 487: 100.00
+	Rn
		1192936 DLG1_RAT (5-724): 0: 550: 67.73		LRFN2_RAT (1-788): 1.59e-160: 487: 98.86
+	Mm
		1180771 DLG4_MOUSE (1-724): 0: 653: 100.00		LRFN1_MOUSE (12-788): 4.76e-115: 368: 44.18
+	Mm
		1223598 DLG4_MOUSE (1-724): 0: 653: 100.00		LRFN4_MOUSE (21-586): 1.46e-94: 310: 55.38
+	Mm
		1180772 DLG1_MOUSE (5-724): 0: 561: 68.98		LRFN1_MOUSE (12-788): 4.76e-115: 368: 44.18
+	Mm
		1223632 DLG4_MOUSE (1-724): 0: 653: 100.00		LRC4C_MOUSE (17-449): 2.12e-65: 231: 22.41
+	Mm
		503541 DLG4_MOUSE (1-724): 0: 653: 100.00		LRC4B_MOUSE (14-378): 8.86e-59: 214: 25.85
+	Mm
		999793 DLG3_MOUSE (20-724): 0: 571: 62.87		LRC4C_MOUSE (17-449): 2.12e-65: 231: 22.41
+	Mm
		1223607 DLG4_MOUSE (1-724): 0: 653: 100.00		NRCAM_MOUSE (114-779): 2.66e-18: 92.5: 11.14
+	Mm
		1283506 DLG1_MOUSE (5-724): 0: 561: 68.98		NRCAM_MOUSE (114-779): 2.66e-18: 92.5: 11.14
+	Hs
		1245251 PALS1_HUMAN (52-184): 5.33e-13: 74.3: 14.93		LRFN4_HUMAN (21-591): 1.02e-97: 318: 55.25
+	Mm
		1297656 DLG2_MOUSE (225-570): 1.26e-17: 89.7: 17.32		LRC4C_MOUSE (17-449): 2.12e-65: 231: 22.41
+	Hs
		1122310 SCRIB_HUMAN (58-243): 7.61e-25: 113: 40.72		LRIG1_HUMAN (26-349): 5.16e-26: 117: 16.05
+	Hs
		1122330 SCRIB_HUMAN (58-243): 7.61e-25: 113: 40.72		LGR4_HUMAN (35-326): 1.4e-21: 102: 16.67