Protein: LRFN4
Leucine-rich repeat and fibronectin type-III domain-containing protein 4

Gene: LRFN4
Organism: Homo sapiens
Interactions: 91
UniProt ID: Q6PJG9

Gene Ontology (top 5):
GO:0005886 - plasma membrane
GO:0009986 - cell surface
GO:0098839 - postsynaptic density membrane
GO:0098978 - glutamatergic synapse
GO:0098982 - GABA-ergic synapse

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

594024

NCK1
SH2/SH3 adapter protein NCK1

3

4

Small-scale

0.861

High

324350

SLIK5
SLIT and NTRK-like protein 5

2

18

High-throughput

0.811

High

1151550

TRIP6
Thyroid receptor-interacting protein 6

2

1

High-throughput

0.811

High

1245260

LIGO1
Leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 1

2

18

High-throughput

0.811

High

222117

NCK2
Cytoplasmic protein NCK2

4

4

Small-scale

0.793

High

299765

MPDZ
Multiple PDZ domain protein

2

20

Small-scale

0.776

High

1245264

SNX27
Sorting nexin-27

2

5

Small-scale

0.737

High

1245247

NT2NA
Notch homolog 2 N-terminal-like protein A

2

6

High-throughput

0.731

High

1245242

ATL4
ADAMTS-like protein 4

2

2

High-throughput

0.700

High

898378

BCAM
Basal cell adhesion molecule

1

6

High-throughput

0.691

High

1245273

LRFN1
Leucine-rich repeat and fibronectin type III domain-containing protein 1

1

18

High-throughput

0.691

High

1245279

LRFN2
Leucine-rich repeat and fibronectin type-III domain-containing protein 2

1

18

High-throughput

0.691

High

480829

LEG1
Galectin-1

2

9

High-throughput

0.628

High

991584

DYL1
Dynein light chain 1, cytoplasmic

2

1

High-throughput

0.628

High

1245254

CIP2A
Protein CIP2A

2

3

High-throughput

0.628

High

1245255

LMBR1
Limb region 1 protein homolog

2

2

High-throughput

0.628

High

1245261

DYL2
Dynein light chain 2, cytoplasmic

2

1

High-throughput

0.628

High

1245246

5HT3D
5-hydroxytryptamine receptor 3D

2

3

High-throughput

0.621

High

1245253

LNX1
E3 ubiquitin-protein ligase LNX

1

20

High-throughput

0.618

High

1245270

WDR76
WD repeat-containing protein 76

1

1

High-throughput

0.618

High

271715

HIP1R
Huntingtin-interacting protein 1-related protein

2

0

High-throughput

0.602

High

517043

NT2NC
Notch homolog 2 N-terminal-like protein C

1

6

High-throughput

0.594

High

966484

1433G
14-3-3 protein gamma

3

7

Small-scale

0.593

High

729962

1433B
14-3-3 protein beta/alpha

3

7

Small-scale

0.587

High

994268

PP2AA
Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform

1

1

Small-scale

0.575

High

1090147

PTN13
Tyrosine-protein phosphatase non-receptor type 13

1

10

Small-scale

0.575

High

1245251

PALS1
Protein PALS1

1

13

Small-scale

0.575

High

1245271

GOPC
Golgi-associated PDZ and coiled-coil motif-containing protein

1

18

Small-scale

0.575

High

1245282

FLVC1
Choline/ethanolamine transporter FLVCR1

1

6

High-throughput

0.575

High

250274

VINEX
Vinexin

2

1

High-throughput

0.574

High

1215439

DEP1A
DEP domain-containing protein 1A

2

1

High-throughput

0.574

High

1245243

UBP30
Ubiquitin carboxyl-terminal hydrolase 30

2

5

High-throughput

0.574

High

1245252

ZSWM2
E3 ubiquitin-protein ligase ZSWIM2

2

1

High-throughput

0.574

High

1245266

TM39B
Transmembrane protein 39B

2

1

High-throughput

0.574

High

1245276

UBP25
Ubiquitin carboxyl-terminal hydrolase 25

2

4

High-throughput

0.574

High

70292

CRTP1
Cysteine-rich tail protein 1

2

1

High-throughput

0.553

High

452299

PDIA1
Protein disulfide-isomerase

2

1

High-throughput

0.553

High

950544

KR108
Keratin-associated protein 10-8

2

20

High-throughput

0.553

High

1059673

KRA11
Keratin-associated protein 1-1

2

20

High-throughput

0.553

High

1245250

KRA13
Keratin-associated protein 1-3

2

20

High-throughput

0.553

High

862665

UTRN
Utrophin

1

0

Small-scale

0.546

High

563939

CFTR
Cystic fibrosis transmembrane conductance regulator

1

2

High-throughput

0.541

High

1207865

S27A3
Long-chain fatty acid transport protein 3

1

7

High-throughput

0.536

High

1245258

T106A
Transmembrane protein 106A

1

5

High-throughput

0.536

High

1245278

FBX2
F-box only protein 2

1

12

High-throughput

0.536

High

1229816

CYTSA
Cytospin-A

1

0

High-throughput

0.517

High

977528

PP2AB
Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform

1

1

Small-scale

0.514

High

889928

VEGFB
Vascular endothelial growth factor B

1

1

High-throughput

0.489

High

1245244

CHSS3
Chondroitin sulfate synthase 3

1

7

High-throughput

0.489

High

990368

1433Z
14-3-3 protein zeta/delta

1

7

Small-scale

0.484

High

1049436

1433F
14-3-3 protein eta

1

7

Small-scale

0.484

High

323742

AP2A2
AP-2 complex subunit alpha-2

1

2

High-throughput

0.479

High

344720

AP2A1
AP-2 complex subunit alpha-1

1

2

High-throughput

0.479

High

1245259

REPS1
RalBP1-associated Eps domain-containing protein 1

1

1

High-throughput

0.479

High

1245257

MY18A
Unconventional myosin-XVIIIa

1

0

High-throughput

0.458

High

189646

STX7
Syntaxin-7

1

5

High-throughput

0.445

High

529975

TAU
Microtubule-associated protein tau

1

2

Small-scale

0.445

High

717866

2AAA
Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform

1

2

Small-scale

0.445

High

1031806

LAT1
Large neutral amino acids transporter small subunit 1

1

3

High-throughput

0.445

High

1245275

CTNL1
Alpha-catulin

1

1

Small-scale

0.445

High

691140

1433T
14-3-3 protein theta

1

7

Small-scale

0.442

High

556

NBPFJ
NBPF family member NBPF19

1

3

High-throughput

0.439

High

1083258

AP1B1
AP-1 complex subunit beta-1

1

3

High-throughput

0.437

High

1245272

FBX6
F-box only protein 6

1

12

High-throughput

0.437

High

1245281

TRRAP
Transformation/transcription domain-associated protein

1

6

High-throughput

0.437

High

537365

HSP7C
Heat shock cognate 71 kDa protein

1

0

Small-scale

0.426

High

881211

FAS
Fatty acid synthase

1

0

Small-scale

0.426

High

801378

HSPA9
Stress-70 protein, mitochondrial

1

2

Small-scale

0.407

High

1245245

CR3L2
Cyclic AMP-responsive element-binding protein 3-like protein 2

1

2

High-throughput

0.407

High

1245265

ANM1
Protein arginine N-methyltransferase 1

1

2

Small-scale

0.407

High

1245274

PI4KB
Phosphatidylinositol 4-kinase beta

1

3

Small-scale

0.407

High

64767

RIMC1
RAB7A-interacting MON1-CCZ1 complex subunit 1

2

0

High-throughput

0.328

High

132737

BMAL1
Basic helix-loop-helix ARNT-like protein 1

2

0

High-throughput

0.328

High

431401

AT5G1
ATP synthase F(0) complex subunit C1, mitochondrial

2

0

High-throughput

0.328

High

505438

CISD3
CDGSH iron-sulfur domain-containing protein 3, mitochondrial

2

0

High-throughput

0.328

High

1245249

PATL1
Protein PAT1 homolog 1

2

0

High-throughput

0.328

High

1245268

GCP60
Golgi resident protein GCP60

2

0

High-throughput

0.328

High

1245269

NSUN3
tRNA

2

0

High-throughput

0.328

High

1245277

MD2L2
Mitotic spindle assembly checkpoint protein MAD2B

2

0

High-throughput

0.328

High

1245283

CAN6
Calpain-6

2

0

High-throughput

0.328

High

1186637

KRA62
Keratin-associated protein 6-2

2

0

High-throughput

0.316

High

1081585

BRME1
Break repair meiotic recombinase recruitment factor 1

1

0

High-throughput

0.279

Low

1245248

HEAT3
HEAT repeat-containing protein 3

1

0

High-throughput

0.279

Low

1245267

TKTL2
Transketolase-like protein 2

1

0

High-throughput

0.279

Low

1245280

SMAG1
Protein Smaug homolog 1

1

0

High-throughput

0.279

Low

971660

1433E
14-3-3 protein epsilon

1

0

Small-scale

0.253

Low

1245024

FBX46
F-box only protein 46

1

0

High-throughput

0.249

Low

697566

PYR1
Multifunctional protein CAD

1

0

Small-scale

0.232

Low

1245256

DDX1
ATP-dependent RNA helicase DDX1

1

0

Small-scale

0.232

Low

1245262

BSCL2
Seipin

1

0

High-throughput

0.232

Low

1245263

TM169
Transmembrane protein 169

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025