Protein: RN111
E3 ubiquitin-protein ligase Arkadia (EC 2.3.2.27) (RING finger protein 111) (hRNF111) (RING-type E3 ubiquitin transferase Arkadia)

Gene: RN111, RNF111
Organism: Homo sapiens
Interactions: 116
UniProt ID: Q6ZNA4

Gene Ontology (top 5):
GO:0000209 - protein polyubiquitination
GO:0005634 - nucleus
GO:0005654 - nucleoplasm
GO:0005737 - cytoplasm
GO:0005829 - cytosol

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

919758

UB2D2
Ubiquitin-conjugating enzyme E2 D2

8

20

Small-scale

0.969

High

1169162

RN111
E3 ubiquitin-protein ligase Arkadia

7

11

Small-scale

0.965

High

895821

UB2D3
Ubiquitin-conjugating enzyme E2 D3

5

20

Small-scale

0.937

High

896473

UBE2N
Ubiquitin-conjugating enzyme E2 N

5

20

Small-scale

0.917

High

849348

UB2D1
Ubiquitin-conjugating enzyme E2 D1

4

20

High-throughput

0.914

High

930271

UBC9
SUMO-conjugating enzyme UBC9

3

20

High-throughput

0.884

High

851828

UB2E1
Ubiquitin-conjugating enzyme E2 E1

3

20

High-throughput

0.867

High

1169175

UB2E3
Ubiquitin-conjugating enzyme E2 E3

3

20

High-throughput

0.867

High

1169176

UBE2W
Ubiquitin-conjugating enzyme E2 W

3

20

High-throughput

0.867

High

896325

UBE2K
Ubiquitin-conjugating enzyme E2 K

3

20

High-throughput

0.849

High

1169203

UB2D4
Ubiquitin-conjugating enzyme E2 D4

2

20

High-throughput

0.815

High

1169179

UB2E2
Ubiquitin-conjugating enzyme E2 E2

2

20

High-throughput

0.800

High

934263

CSK21
Casein kinase II subunit alpha

6

5

High-throughput

0.741

High

586817

CSK22
Casein kinase II subunit alpha'

5

6

High-throughput

0.718

High

950208

SMAD3
Mothers against decapentaplegic homolog 3

5

9

Small-scale

0.702

High

891411

UB2G2
Ubiquitin-conjugating enzyme E2 G2

1

20

High-throughput

0.698

High

896131

UBC12
NEDD8-conjugating enzyme Ubc12

1

20

High-throughput

0.698

High

1033116

UB2V1
Ubiquitin-conjugating enzyme E2 variant 1

1

20

High-throughput

0.698

High

642095

KRA59
Keratin-associated protein 5-9

4

3

High-throughput

0.697

High

299399

UBXN7
UBX domain-containing protein 7

3

7

High-throughput

0.681

High

902641

SUMO2
Small ubiquitin-related modifier 2

3

5

Small-scale

0.680

High

167371

SMAD7
Mothers against decapentaplegic homolog 7

4

9

Small-scale

0.680

High

928120

SUMO1
Small ubiquitin-related modifier 1

3

5

Small-scale

0.670

High

227830

PRKN
E3 ubiquitin-protein ligase parkin

1

13

High-throughput

0.665

High

521370

SKIL
Ski-like protein

3

4

Small-scale

0.664

High

1169171

UB2Q2
Ubiquitin-conjugating enzyme E2 Q2

1

0

High-throughput

0.663

High

668773

PML
Protein PML

3

4

Small-scale

0.658

High

475941

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

1

13

Small-scale

0.647

High

932536

UB2L3
Ubiquitin-conjugating enzyme E2 L3

1

20

Small-scale

0.647

High

1078999

UB2V2
Ubiquitin-conjugating enzyme E2 variant 2

1

20

Small-scale

0.647

High

521281

SKI
Ski oncogene

3

4

Small-scale

0.640

High

1078571

SMAD2
Mothers against decapentaplegic homolog 2

3

9

Small-scale

0.640

High

941077

RNF4
E3 ubiquitin-protein ligase RNF4

1

6

High-throughput

0.618

High

931696

CSK2B
Casein kinase II subunit beta

2

2

High-throughput

0.611

High

170675

AXIN1
Axin-1

2

3

Small-scale

0.586

High

1169172

EDAD
Ectodysplasin-A receptor-associated adapter protein

1

0

High-throughput

0.549

High

129572

TRAF5
TNF receptor-associated factor 5

1

7

High-throughput

0.541

High

507455

ERG
Transcriptional regulator ERG

1

8

High-throughput

0.541

High

584992

RO52
E3 ubiquitin-protein ligase TRIM21

1

3

High-throughput

0.541

High

1165200

LRSM1
E3 ubiquitin-protein ligase LRSAM1

1

2

High-throughput

0.541

High

1169168

DTX3L
E3 ubiquitin-protein ligase DTX3L

1

1

High-throughput

0.541

High

1169183

TS101
Tumor susceptibility gene 101 protein

1

2

High-throughput

0.541

High

1169185

PHF7
PHD finger protein 7

1

3

High-throughput

0.541

High

1169187

TRIM8
E3 ubiquitin-protein ligase TRIM8

1

4

High-throughput

0.541

High

1169191

MARH7
E3 ubiquitin-protein ligase MARCHF7

1

2

High-throughput

0.541

High

1169194

APC11
Anaphase-promoting complex subunit 11

1

3

High-throughput

0.541

High

1169186

LOXE3
Hydroperoxide isomerase ALOXE3

1

1

High-throughput

0.536

High

1169197

SPAST
Spastin

1

7

High-throughput

0.536

High

72142

B3KSH4
Huntingtin interacting protein 2, isoform CRA_a

1

20

High-throughput

0.528

High

556897

CREB1
Cyclic AMP-responsive element-binding protein 1

1

0

High-throughput

0.518

High

336528

SODC
Superoxide dismutase [Cu-Zn]

1

2

High-throughput

0.515

High

394999

A4
Amyloid-beta precursor protein

1

5

High-throughput

0.515

High

642776

ELAV4
ELAV-like protein 4

1

3

High-throughput

0.515

High

791689

HD
Huntingtin

1

1

High-throughput

0.515

High

868231

ATX3
Ataxin-3

1

2

High-throughput

0.515

High

868563

ATX1
Ataxin-1

1

1

High-throughput

0.515

High

1169177

OPTN
Optineurin

1

2

High-throughput

0.515

High

787744

HUTH
Histidine ammonia-lyase

1

0

High-throughput

0.513

High

837619

GNAQ
Guanine nucleotide-binding protein G(q) subunit alpha

1

0

High-throughput

0.513

High

883420

CF298
Cilia- and flagella-associated protein 298

1

0

High-throughput

0.513

High

1109508

KR151
Keratin-associated protein 15-1

1

0

High-throughput

0.513

High

1169164

SUGP1
SURP and G-patch domain-containing protein 1

1

0

High-throughput

0.513

High

1169184

DCNL5
DCN1-like protein 5

1

0

High-throughput

0.513

High

1169196

RBM27
RNA-binding protein 27

1

0

High-throughput

0.513

High

1169199

ADDG
Gamma-adducin

1

0

High-throughput

0.513

High

1169200

CGBP1
CGG triplet repeat-binding protein 1

1

0

High-throughput

0.513

High

1169201

TPX2
Targeting protein for Xklp2

1

0

High-throughput

0.513

High

1169192

SMUF2
E3 ubiquitin-protein ligase SMURF2

1

5

High-throughput

0.508

High

879125

SUMO3
Small ubiquitin-related modifier 3

1

5

Small-scale

0.501

High

361497

APOE
Apolipoprotein E

1

0

High-throughput

0.493

High

742361

SYUA
Alpha-synuclein

1

0

High-throughput

0.493

High

834307

PSN1
Presenilin-1

1

0

High-throughput

0.493

High

1169173

NDRG1
Protein NDRG1

1

0

High-throughput

0.493

High

1169181

PARK7
Parkinson disease protein 7

1

0

High-throughput

0.493

High

1169193

TYDP1
Tyrosyl-DNA phosphodiesterase 1

1

0

High-throughput

0.493

High

1169165

NRSN1
Neurensin-1

1

2

High-throughput

0.489

High

1169166

TTC9C
Tetratricopeptide repeat protein 9C

1

4

High-throughput

0.489

High

1169198

FBLN5
Fibulin-5

1

2

High-throughput

0.489

High

310688

VAPB
Vesicle-associated membrane protein-associated protein B/C

1

6

High-throughput

0.481

High

640254

PTN3
Tyrosine-protein phosphatase non-receptor type 3

1

9

High-throughput

0.481

High

641456

PAX6
Paired box protein Pax-6

1

10

High-throughput

0.481

High

991606

KRA11
Keratin-associated protein 1-1

1

2

High-throughput

0.481

High

993264

ACTN3
Alpha-actinin-3

1

2

High-throughput

0.481

High

1169163

NT2NA
Notch homolog 2 N-terminal-like protein A

1

3

High-throughput

0.481

High

1169174

CBP
CREB-binding protein

1

2

Small-scale

0.481

High

1169188

TSYL1
Testis-specific Y-encoded-like protein 1

1

1

High-throughput

0.481

High

1169189

SDCB2
Syntenin-2

1

2

High-throughput

0.481

High

206966

SMAD6
Mothers against decapentaplegic homolog 6

1

9

Small-scale

0.479

High

431981

HS90A
Heat shock protein HSP 90-alpha

1

5

High-throughput

0.479

High

438289

HS90B
Heat shock protein HSP 90-beta

1

5

High-throughput

0.479

High

611458

NR4A1
Nuclear receptor subfamily 4immunitygroup A member 1

1

14

Small-scale

0.479

High

631477

BRD2
Bromodomain-containing protein 2

1

3

High-throughput

0.479

High

967043

XPC
DNA repair protein complementing XP-C cells

1

1

Small-scale

0.479

High

1050682

FHL2
Four and a half LIM domains protein 2

1

3

Small-scale

0.479

High

1081223

NF2L2
Nuclear factor erythroid 2-related factor 2

1

4

Small-scale

0.479

High

1157127

ESRP1
Epithelial splicing regulatory protein 1

1

3

Small-scale

0.479

High

1169167

CSK23
Casein kinase II subunit alpha 3

1

5

High-throughput

0.479

High

1169169

RBCC1
RB1-inducible coiled-coil protein 1

1

5

Small-scale

0.479

High

1169170

SETD7
Histone-lysine N-methyltransferase SETD7

1

2

Small-scale

0.479

High

1169190

ESRP2
Epithelial splicing regulatory protein 2

1

4

Small-scale

0.479

High

1169195

CDK12
Cyclin-dependent kinase 12

1

3

High-throughput

0.479

High

1169202

AXIN2
Axin-2

1

3

Small-scale

0.479

High

70403

B2R8Y4
cDNA, FLJ94117, highly similar to Homo sapiens actinin, alpha 3

1

2

High-throughput

0.470

High

557

NBPFJ
Neuroblastoma breakpoint family member 19

1

0

High-throughput

0.460

High

898942

PSME3
Proteasome activator complex subunit 3

1

0

High-throughput

0.460

High

1032480

CTBP1
C-terminal-binding protein 1

1

0

High-throughput

0.460

High

1058945

MVP
Major vault protein

1

0

High-throughput

0.460

High

1169178

AP2M1
AP-2 complex subunit mu

1

0

High-throughput

0.460

High

1169182

MDFI
MyoD family inhibitor

1

0

High-throughput

0.460

High

506609

BCR
Breakpoint cluster region protein

1

0

High-throughput

0.458

High

991806

KHDR1
KH domain-containing, RNA-binding, signal transduction-associated protein 1

1

0

High-throughput

0.438

High

1169180

CF418
Cilia- and flagella-associated protein 418

1

0

Small-scale

0.438

High

483700

CT456
Cancer/testis antigen family 45 member A6

1

1

High-throughput

0.407

High

1135622

LCE4A
Late cornified envelope protein 4A

1

0

High-throughput

0.299

High

946403

EREP3
Protein ENTREP3

1

0

High-throughput

0.279

Low


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Last updated: 15 Jul 2024