HitPredict

Interactor 1: ABI1 (Q8IZP0)
Abl interactor 1 (Abelson interactor 1) (Abi-1) (Abl-binding protein 4) (AblBP4) (Eps8 SH3 domain-binding protein) (Eps8-binding protein) (Nap1-binding protein) (Nap1BP) (Spectrin SH3 domain-binding protein 1) (e3B1)
Gene: ABI1

Interactor 2: ENAH (Q8N8S7)
Protein enabled homolog
Gene: ENAH

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.76	0.60	0.679

Property	Details
Experiments	12672821, 17101133, 26496610
Identification Methods	two hybrid, affinity chromatography technology, pull down, anti tag coimmunoprecipitation
Interaction Type	direct interaction, physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005829 - cytosol GO:0005856 - cytoskeleton GO:0008154 - actin polymerization or depolymerization GO:0017124 - SH3 domain binding GO:0030027 - lamellipodium
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 508 Hs			1 591
+	Mm
		1208103 ABI1_MOUSE (1-508): 1.42e-122: 369: 91.93		MINK1_MOUSE (113-575): 8.76e-40: 158: 16.21
+	Hs
		1205704 ABI1_HUMAN (1-508): 3.82e-124: 374: 100.00		HOME1_HUMAN (1-285): 2.84e-39: 149: 15.64
+	Hs
		1237890 ABI2_HUMAN (1-508): 1.41e-81: 264: 59.84		ENAH_HUMAN (1-591): 2.13e-77: 258: 100.00
+	Mm
		949371 ABI1_MOUSE (1-508): 1.42e-122: 369: 91.93		TNIK_MOUSE (90-575): 1.04e-33: 139: 14.08
+	Hs
		1224647 ABI1_HUMAN (1-508): 3.82e-124: 374: 100.00		HOME3_HUMAN (3-274): 2.31e-31: 127: 19.42
+	Hs
		840522 ABI1_HUMAN (1-508): 3.82e-124: 374: 100.00		VASP_HUMAN (263-590): 7.68e-20: 93.6: 29.18
+	Mm
		913883 ABI2_MOUSE (1-508): 4.85e-88: 279: 61.18		TNIK_MOUSE (90-575): 1.04e-33: 139: 14.08
+	Hs
		1345510 ABI2_HUMAN (1-508): 1.41e-81: 264: 59.84		HOME3_HUMAN (3-274): 2.31e-31: 127: 19.42
+	Hs
		160207 ABI2_HUMAN (1-508): 1.41e-81: 264: 59.84		HGS_HUMAN (90-385): 6.31e-28: 120: 22.22
+	Dm
		1250361 Q9Y0S9_DROME (1-504): 2.01e-77: 252: 34.72		ENA_DROME (2-491): 1.84e-26: 116: 23.88
+	Hs
		840586 ABI2_HUMAN (1-508): 1.41e-81: 264: 59.84		VASP_HUMAN (263-590): 7.68e-20: 93.6: 29.18
+	Hs
		1052272 SRC8_HUMAN (291-502): 1.23e-34: 138: 20.72		CTTB2_HUMAN (87-571): 1.34e-43: 169: 13.08
+	Hs
		203228 SYNJ1_HUMAN (38-463): 1.36e-41: 161: 11.55		ITSN1_HUMAN (124-263): 2.96e-29: 125: 37.59
+	Hs
		203214 SYNJ1_HUMAN (38-463): 1.36e-41: 161: 11.55		VASP_HUMAN (263-590): 7.68e-20: 93.6: 29.18
+	Mm
		936832 LASP1_MOUSE (285-503): 1.88e-32: 126: 19.73		VASP_MOUSE (380-590): 1.28e-29: 122: 33.18
+	Hs
		160000 LASP1_HUMAN (285-503): 9.91e-33: 127: 19.28		HGS_HUMAN (90-385): 6.31e-28: 120: 22.22
+	Hs
		166049 SYNJ2_HUMAN (39-458): 2.1e-26: 115: 13.88		ITSN1_HUMAN (124-263): 2.96e-29: 125: 37.59
+	Hs
		840475 LASP1_HUMAN (285-503): 9.91e-33: 127: 19.28		VASP_HUMAN (263-590): 7.68e-20: 93.6: 29.18
+	Hs
		166036 SYNJ2_HUMAN (39-458): 2.1e-26: 115: 13.88		VASP_HUMAN (263-590): 7.68e-20: 93.6: 29.18
+	Hs
		166056 SYNJ2_HUMAN (39-458): 2.1e-26: 115: 13.88		ITSN2_HUMAN (102-259): 2.05e-10: 66.1: 25.63