HitPredict

Interactor 1: HGS (O14964)
Hepatocyte growth factor-regulated tyrosine kinase substrate (Hrs) (Protein pp110)
Gene: HGS

Interactor 2: GGA2 (Q9UJY4)
ADP-ribosylation factor-binding protein GGA2 (Gamma-adaptin-related protein 2) (Golgi-localized, gamma ear-containing, ARF-binding protein 2) (VHS domain and ear domain of gamma-adaptin) (Vear)
Gene: GGA2

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.57	1.00	0.757

Property	Details
Experiments	19019082, 15611048
Identification Methods	pull down, two hybrid
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	FYVE~VHS, VHS~VHS
Common GO terms	GO:0031901 - early endosome membrane GO:0035091 - phosphatidylinositol binding GO:0043130 - ubiquitin binding
Homologous interactions	18

Homologous interactions

Color coding for hit scores

	1 777 Hs			1 613
+	Hs
		160224 HGS_HUMAN (1-777): 5.12e-104: 338: 100.00		GGA1_HUMAN (19-612): 1.68e-159: 473: 44.67
+	Hs
		1348858 GGA3_HUMAN (6-678): 1.67e-44: 173: 13.14		GGA2_HUMAN (12-613): 0: 556: 100.00
+	Hs
		159801 HGS_HUMAN (1-777): 5.12e-104: 338: 100.00		TOM1_HUMAN (23-495): 1.66e-100: 316: 19.02
+	Hs
		159809 HGS_HUMAN (1-777): 5.12e-104: 338: 100.00		STAM2_HUMAN (19-521): 4.17e-99: 313: 17.66
+	Hs
		1348859 GGA3_HUMAN (6-678): 1.67e-44: 173: 13.14		GGA1_HUMAN (19-612): 1.68e-159: 473: 44.67
+	Hs
		160122 HGS_HUMAN (1-777): 5.12e-104: 338: 100.00		STAM1_HUMAN (19-524): 3.22e-96: 306: 15.76
+	Mm
		292346 HGS_MOUSE (1-777): 2.55e-98: 323: 93.31		STAM2_MOUSE (19-517): 3.69e-100: 316: 17.89
+	Hs
		159808 HGS_HUMAN (1-777): 5.12e-104: 338: 100.00		TM1L1_HUMAN (23-494): 3.31e-86: 278: 18.01
+	Hs
		212669 GGA3_HUMAN (6-678): 1.67e-44: 173: 13.14		AP1G1_HUMAN (44-610): 7.48e-109: 347: 17.44
+	Hs
		160208 HGS_HUMAN (1-777): 5.12e-104: 338: 100.00		GGA3_HUMAN (328-611): 1.6e-47: 179: 32.33
+	Hs
		277104 STAM2_HUMAN (4-521): 4.17e-52: 191: 15.91		STAM1_HUMAN (19-524): 3.22e-96: 306: 15.76
+	Sc
		755527 GGA2_YEAST (6-566): 5.19e-39: 155: 13.43		GGA2_YEAST (15-607): 3.14e-107: 336: 19.31
+	Hs
		241128 TOM1_HUMAN (5-428): 1.81e-54: 197: 18.16		TM1L1_HUMAN (23-494): 3.31e-86: 278: 18.01
+	Hs
		241175 ZFY16_HUMAN (137-497): 7.73e-39: 158: 17.76		TOM1_HUMAN (23-495): 1.66e-100: 316: 19.02
+	Hs
		277083 ZFY16_HUMAN (137-497): 7.73e-39: 158: 17.76		STAM2_HUMAN (19-521): 4.17e-99: 313: 17.66
+	Hs
		276978 ZFYV9_HUMAN (155-489): 1.2e-38: 157: 20.63		STAM2_HUMAN (19-521): 4.17e-99: 313: 17.66
+	At
		1226454 TOL5_ARATH (8-422): 2.49e-40: 156: 16.20		TOL9_ARATH (26-566): 4.13e-91: 297: 17.77
+	Hs
		1348855 GGA3_HUMAN (6-678): 1.67e-44: 173: 13.14		GGA3_HUMAN (328-611): 1.6e-47: 179: 32.33