HitPredict

Interactor 1: GOSR2 (O14653)
Golgi SNAP receptor complex member 2 (27 kDa Golgi SNARE protein) (Membrin)
Gene: GOSR2

Interactor 2: STX8 (Q9UNK0)
Syntaxin-8
Gene: STX8

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	1.00	0.691

Property	Details
Experiments	33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	SNARE~V-SNARE_C
Common GO terms	GO:0000149 - SNARE binding GO:0005484 - SNAP receptor activity GO:0006906 - vesicle fusion GO:0031201 - SNARE complex
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 212 Hs			1 236
+	At
		1375200 VTI12_ARATH (1-210): 7.5e-53: 171: 14.87		SYP61_ARATH (2-235): 1.31e-61: 195: 20.75
+	Hs
		160226 GOSR2_HUMAN (1-212): 5.81e-61: 191: 100.00		STX6_HUMAN (3-221): 2.27e-43: 148: 17.30
+	Hs
		249887 VTI1A_HUMAN (2-210): 3.4e-52: 169: 11.96		STX10_HUMAN (3-221): 2.25e-51: 168: 17.39
+	At
		1456167 VTI11_ARATH (1-191): 2.82e-50: 164: 14.36		SYP51_ARATH (2-235): 7.86e-53: 172: 23.50
+	Hs
		1217087 VTI1A_HUMAN (2-210): 3.4e-52: 169: 11.96		Q5U8S2_HUMAN (3-212): 1.44e-48: 161: 17.65
+	Mm
		313465 VTI1A_MOUSE (2-211): 6.65e-55: 176: 12.38		STX6_MOUSE (3-221): 2.41e-45: 153: 17.72
+	Hs
		1383316 VTI1A_HUMAN (2-210): 3.4e-52: 169: 11.96		STX8_HUMAN (1-218): 7.58e-47: 156: 100.00
+	Rn
		1224613 VTI1A_RAT (2-211): 8.39e-52: 168: 12.09		STX6_RAT (3-222): 3.22e-46: 155: 17.65
+	Dm
		1484998 GOSR2_DROME (1-211): 5.04e-53: 171: 41.12		Q9VV76_DROME (4-223): 7.24e-43: 146: 24.32
+	Hs
		226165 VTI1A_HUMAN (2-210): 3.4e-52: 169: 11.96		STX6_HUMAN (3-221): 2.27e-43: 148: 17.30
+	Mm
		1362332 Q91XH6_MOUSE (2-210): 9.45e-50: 163: 14.88		STX6_MOUSE (3-221): 2.41e-45: 153: 17.72
+	Rn
		204396 GOSR2_RAT (1-212): 1.8e-63: 197: 91.04		BET1_RAT (149-234): 6.71e-26: 99.1: 22.09
+	Dm
		1487160 Q9W0N6_DROME (1-212): 7.23e-45: 150: 17.89		Q9VV76_DROME (4-223): 7.24e-43: 146: 24.32
+	Hs
		226247 VTI1B_HUMAN (2-190): 7.64e-44: 148: 14.36		STX6_HUMAN (3-221): 2.27e-43: 148: 17.30
+	Hs
		160223 GOSR2_HUMAN (1-212): 5.81e-61: 191: 100.00		BET1_HUMAN (149-234): 6.34e-25: 96.8: 18.61
+	Hs
		343437 VTI1A_HUMAN (2-210): 3.4e-52: 169: 11.96		SNP29_HUMAN (10-207): 2.96e-28: 109: 20.50
+	Hs
		180009 VTI1A_HUMAN (2-210): 3.4e-52: 169: 11.96		BET1_HUMAN (149-234): 6.34e-25: 96.8: 18.61
+	Hs
		180094 VTI1B_HUMAN (2-190): 7.64e-44: 148: 14.36		BET1_HUMAN (149-234): 6.34e-25: 96.8: 18.61
+	Dm
		1484999 GOSR2_DROME (1-211): 5.04e-53: 171: 41.12		Q9VVX6_DROME (161-234): 4.71e-13: 65.7: 20.00
+	Dm
		1487520 Q9W0N6_DROME (1-212): 7.23e-45: 150: 17.89		Q9VVX6_DROME (161-234): 4.71e-13: 65.7: 20.00