HitPredict

Interactor 1: VHL (Q64259)
von Hippel-Lindau disease tumor suppressor (pVHL)
Gene: VHL

Interactor 2: EPAS1 (Q9JHS1)
Endothelial PAS domain-containing protein 1 (EPAS-1) (Hypoxia-inducible factor 2-alpha) (HIF-2-alpha) (HIF2-alpha)
Gene: EPAS1

Species: Rattus norvegicus

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	12675925
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	HIF-1~VHL
Common GO terms	GO:0000122 - negative regulation of transcription by RNA polymerase II GO:0001525 - angiogenesis GO:0001666 - response to hypoxia GO:0005634 - nucleus GO:0005667 - transcription regulator complex and 1 others more... GO:0005737 - cytoplasm
Homologous interactions	8

Homologous interactions

Color coding for hit scores

	1 185 Rn			1 874
+	Mm
		822941 VHL_MOUSE (1-181): 2.28e-121: 341: 93.37		EPAS1_MOUSE (1-874): 0: 777: 93.02
+	Hs
		822832 VHL_HUMAN (2-179): 8.61e-109: 311: 80.95		EPAS1_HUMAN (1-874): 0: 771: 85.26
+	Rn
		205566 VHL_RAT (1-185): 1.36e-126: 355: 100.00		HIF1A_RAT (3-872): 0: 574: 40.26
+	Hs
		822689 VHL_HUMAN (2-179): 8.61e-109: 311: 80.95		HIF1A_HUMAN (3-872): 0: 569: 41.43
+	Mm
		822943 VHL_MOUSE (1-181): 2.28e-121: 341: 93.37		HIF1A_MOUSE (3-792): 5.2e-168: 511: 41.06
+	Hs
		1161308 VHLL_HUMAN (27-119): 6.55e-58: 179: 72.04		HIF1A_HUMAN (3-872): 0: 569: 41.43
+	Hs
		693259 VHL_HUMAN (2-179): 8.61e-109: 311: 80.95		ARNT_HUMAN (2-733): 3.98e-123: 392: 17.72
+	Hs
		822915 VHL_HUMAN (2-179): 8.61e-109: 311: 80.95		HIF3A_HUMAN (1-725): 6.42e-118: 375: 35.84