HitPredict

Interactor 1: SPK1 (Q8SAB7)
Guanine nucleotide exchange factor SPIKE 1
Gene: SPK1

Interactor 2: RAC8 (Q9SU67)
Rac-like GTP-binding protein ARAC8 (GTPase protein ROP10)
Gene: ARAC8

Species: Arabidopsis thaliana

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.41	1.00	0.647

Property	Details
Experiments	18308939
Identification Methods	pull down
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	DHR-2_Lobe_B~Ras, DHR-2_Lobe_C~Ras
Common GO terms	GO:0007264 - small GTPase-mediated signal transduction GO:0008360 - regulation of cell shape
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1830 At			1 208
+	At
		287603 SPK1_ARATH (1-1830): 0: 2088: 100.00		RAC10_ARATH (1-207): 1.44e-81: 243: 87.62
+	At
		1248269 SPK1_ARATH (1-1830): 0: 2088: 100.00		RAC9_ARATH (9-192): 5.82e-78: 234: 72.28
+	At
		1105166 SPK1_ARATH (1-1830): 0: 2088: 100.00		RAC5_ARATH (1-180): 1.61e-77: 232: 81.11
+	At
		1105136 SPK1_ARATH (1-1830): 0: 2088: 100.00		RAC4_ARATH (1-180): 5.8e-77: 231: 81.11
+	At
		1248267 SPK1_ARATH (1-1830): 0: 2088: 100.00		RAC6_ARATH (1-180): 5.61e-77: 231: 79.44
+	At
		1105105 SPK1_ARATH (1-1830): 0: 2088: 100.00		RAC1_ARATH (1-180): 1.78e-76: 230: 80.00
+	Hs
		925332 DOC11_HUMAN (77-1827): 0: 1614: 21.33		RAC1_HUMAN (9-191): 3.32e-80: 239: 59.46
+	Hs
		545421 DOC11_HUMAN (77-1827): 0: 1614: 21.33		RAC2_HUMAN (9-190): 2.28e-76: 229: 58.15
+	Hs
		892410 DOC11_HUMAN (77-1827): 0: 1614: 21.33		RAC3_HUMAN (9-180): 1.76e-76: 229: 59.77
+	Hs
		951301 DOCK9_HUMAN (46-1827): 0: 1537: 19.31		RHOG_HUMAN (7-190): 5.91e-90: 263: 54.84
+	Hs
		925588 DOCK9_HUMAN (46-1827): 0: 1537: 19.31		RAC1_HUMAN (9-191): 3.32e-80: 239: 59.46
+	Hs
		545596 DOCK9_HUMAN (46-1827): 0: 1537: 19.31		RAC2_HUMAN (9-190): 2.28e-76: 229: 58.15
+	Hs
		892573 DOCK9_HUMAN (46-1827): 0: 1537: 19.31		RAC3_HUMAN (9-180): 1.76e-76: 229: 59.77
+	Hs
		925518 DOCK6_HUMAN (16-979): 0: 755: 20.07		RAC1_HUMAN (9-191): 3.32e-80: 239: 59.46
+	Hs
		925526 DOCK7_HUMAN (14-731): 0: 656: 21.52		RAC1_HUMAN (9-191): 3.32e-80: 239: 59.46
+	Hs
		925448 DOCK8_HUMAN (14-731): 0: 602: 20.24		RAC1_HUMAN (9-191): 3.32e-80: 239: 59.46
+	Hs
		925429 DOCK4_HUMAN (463-1026): 7.18e-139: 479: 16.22		RAC1_HUMAN (9-191): 3.32e-80: 239: 59.46
+	Dm
		776892 Q8MQW7_DROME (1270-1830): 2.47e-131: 446: 15.17		RAC1_DROME (9-191): 1.47e-77: 232: 57.84
+	Hs
		925425 DOCK3_HUMAN (463-1026): 4.99e-70: 264: 15.18		RAC1_HUMAN (9-191): 3.32e-80: 239: 59.46
+	Mm
		925807 DOCK1_MOUSE (463-1017): 1.06e-47: 190: 15.15		RAC1_MOUSE (9-191): 3.32e-80: 239: 59.46