HitPredict

Interactor 1: NKG2A (P26715)
NKG2-A/NKG2-B type II integral membrane protein (CD159 antigen-like family member A) (NK cell receptor A) (NKG2-A/B-activating NK receptor) (CD antigen CD159a)
Gene: KLRC1

Interactor 2: CLC2D (Q9UHP7)
C-type lectin domain family 2 member D (Lectin-like NK cell receptor) (Lectin-like transcript 1) (LLT-1) (Osteoclast inhibitory lectin)
Gene: CLEC2D

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.61	1.00	0.783

Property	Details
Experiments	32296183, unassigned1304
Identification Methods	two hybrid, two hybrid prey pooling approach, two hybrid array, validated two hybrid
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	Lectin_C~Lectin_C
Common GO terms	GO:0004888 - transmembrane signaling receptor activity GO:0005886 - plasma membrane GO:0007166 - cell surface receptor signaling pathway GO:0009897 - external side of plasma membrane GO:0030246 - carbohydrate binding
Homologous interactions	17

Homologous interactions

Color coding for hit scores

	1 233 Hs			1 191
+	Hs
		688524 NKG2C_HUMAN (1-233): 2.52e-72: 221: 74.25		NKG2A_HUMAN (23-188): 8.76e-38: 131: 19.77
+	Hs
		688611 NKG2A_HUMAN (1-233): 3.23e-72: 221: 100.00		KLRG1_HUMAN (26-186): 1.05e-36: 127: 20.61
+	Hs
		688621 NKG2A_HUMAN (1-233): 3.23e-72: 221: 100.00		CLC7A_HUMAN (20-187): 1.12e-35: 126: 20.00
+	Hs
		1207974 COL12_HUMAN (106-231): 2.3e-41: 151: 20.86		CLC2D_HUMAN (1-191): 5.75e-63: 194: 100.00
+	Hs
		688554 NKG2A_HUMAN (1-233): 3.23e-72: 221: 100.00		KLRD1_HUMAN (33-189): 2.78e-34: 121: 24.72
+	Hs
		688661 NKG2C_HUMAN (1-233): 2.52e-72: 221: 74.25		KLRD1_HUMAN (33-189): 2.78e-34: 121: 24.72
+	Hs
		565106 PGCB_HUMAN (14-233): 4.02e-51: 179: 18.80		CSPG2_HUMAN (43-189): 7.22e-44: 157: 19.50
+	Hs
		1059313 NKG2E_HUMAN (1-225): 2.64e-67: 209: 68.58		KLRD1_HUMAN (33-189): 2.78e-34: 121: 24.72
+	Hs
		1432263 CLC4M_HUMAN (95-232): 1.96e-43: 152: 21.48		CLC4M_HUMAN (72-188): 3.33e-45: 155: 28.68
+	Mm
		1298778 C209B_MOUSE (10-231): 1.82e-51: 171: 16.80		C209B_MOUSE (72-190): 2.76e-38: 135: 25.39
+	Hs
		455981 CL17A_HUMAN (118-232): 2.83e-43: 151: 20.33		ASGR2_HUMAN (23-189): 2.72e-46: 155: 21.08
+	Hs
		62130 KLRG2_HUMAN (75-231): 3.27e-45: 157: 24.05		COL12_HUMAN (64-191): 3.06e-40: 146: 23.24
+	Hs
		1432264 CLC4M_HUMAN (95-232): 1.96e-43: 152: 21.48		CD209_HUMAN (72-188): 3.51e-43: 150: 30.23
+	Hs
		1253997 CL17A_HUMAN (118-232): 2.83e-43: 151: 20.33		CL17A_HUMAN (72-187): 3.97e-40: 141: 31.20
+	Hs
		688638 NKG2A_HUMAN (1-233): 3.23e-72: 221: 100.00		MRC2_HUMAN (51-187): 2.14e-12: 66.6: 11.25
+	Hs
		1207946 COL12_HUMAN (106-231): 2.3e-41: 151: 20.86		CL12A_HUMAN (48-191): 1.64e-34: 124: 23.33
+	Hs
		1207957 COL12_HUMAN (106-231): 2.3e-41: 151: 20.86		CLC4F_HUMAN (77-152): 6.05e-26: 105: 33.77