HitPredict

Interactor 1: WWP2 (O00308)
NEDD4-like E3 ubiquitin-protein ligase WWP2 (EC 2.3.2.26) (Atrophin-1-interacting protein 2) (AIP2) (HECT-type E3 ubiquitin transferase WWP2) (WW domain-containing protein 2)
Gene: WWP2

Interactor 2: STAM1 (Q92783)
Signal transducing adapter molecule 1 (STAM-1)
Gene: STAM

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.41	0.60	0.501

Property	Details
Experiments	35331737
Identification Methods	enzymatic study
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005829 - cytosol
Homologous interactions	19

Homologous interactions

Color coding for hit scores

	1 870 Hs			1 540
+	Hs
		1270607 ITCH_HUMAN (1-870): 0: 902: 54.26		STAM1_HUMAN (1-518): 1.32e-126: 382: 100.00
+	Hs
		277114 ITCH_HUMAN (1-870): 0: 902: 54.26		STAM2_HUMAN (1-533): 8.53e-122: 369: 54.65
+	Hs
		125533 WWP2_HUMAN (1-870): 0: 982: 100.00		TM1L2_HUMAN (6-435): 1.81e-70: 236: 18.45
+	Hs
		125035 WWP2_HUMAN (1-870): 0: 982: 100.00		TOM1_HUMAN (6-454): 3.66e-69: 232: 16.81
+	Hs
		1294876 ITCH_HUMAN (1-870): 0: 902: 54.26		GGA3_HUMAN (1-530): 3.3e-63: 221: 15.64
+	Hs
		125001 WWP2_HUMAN (1-870): 0: 982: 100.00		HGS_HUMAN (84-540): 8.62e-15: 79.4: 13.50
+	Hs
		125051 WWP2_HUMAN (1-870): 0: 982: 100.00		GRAP2_HUMAN (213-264): 2.75e-14: 75.9: 57.69
+	Hs
		125348 WWP2_HUMAN (1-870): 0: 982: 100.00		GRB2_HUMAN (215-265): 2.32e-13: 71.2: 54.90
+	Hs
		160143 ITCH_HUMAN (1-870): 0: 902: 54.26		HGS_HUMAN (84-540): 8.62e-15: 79.4: 13.50
+	Hs
		275221 ITCH_HUMAN (1-870): 0: 902: 54.26		GRAP2_HUMAN (213-264): 2.75e-14: 75.9: 57.69
+	Hs
		808171 NEDD4_HUMAN (90-867): 0: 731: 35.94		TM1L2_HUMAN (6-435): 1.81e-70: 236: 18.45
+	Hs
		241153 NEDD4_HUMAN (90-867): 0: 731: 35.94		TOM1_HUMAN (6-454): 3.66e-69: 232: 16.81
+	Hs
		808298 NEDD4_HUMAN (90-867): 0: 731: 35.94		GGA3_HUMAN (1-530): 3.3e-63: 221: 15.64
+	Hs
		160160 NED4L_HUMAN (5-867): 0: 785: 32.17		HGS_HUMAN (84-540): 8.62e-15: 79.4: 13.50
+	Hs
		159925 NEDD4_HUMAN (90-867): 0: 731: 35.94		HGS_HUMAN (84-540): 8.62e-15: 79.4: 13.50
+	Hs
		1173029 SMUF1_HUMAN (1-385): 1.35e-45: 177: 17.77		TM1L2_HUMAN (6-435): 1.81e-70: 236: 18.45
+	Hs
		241199 SMUF1_HUMAN (1-385): 1.35e-45: 177: 17.77		TOM1_HUMAN (6-454): 3.66e-69: 232: 16.81
+	Sc
		753622 RSP5_YEAST (16-376): 1.4e-39: 159: 18.39		HSE1_YEAST (15-488): 6.22e-57: 198: 21.37
+	Sc
		765278 RSP5_YEAST (16-376): 1.4e-39: 159: 18.39		VPS27_YEAST (1-163): 3.77e-36: 144: 26.63