HitPredict

Interactor 1: ARVC (O00192)
Splicing regulator ARVCF (Armadillo repeat protein deleted in velo-cardio-facial syndrome)
Gene: ARVCF

Interactor 2: CADH5 (P33151)
Cadherin-5 (7B4 antigen) (Vascular endothelial cadherin) (VE-cadherin) (CD antigen CD144)
Gene: CDH5

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.65	1.00	0.811

Property	Details
Experiments	28514442, 33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	Arm~CADH_Y-type_LIR
Common GO terms	GO:0005737 - cytoplasm GO:0005886 - plasma membrane GO:0005912 - adherens junction GO:0045296 - cadherin binding GO:0098609 - cell-cell adhesion
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 962 Hs			1 784
+	Hs
		254067 CTND1_HUMAN (1-933): 0: 750: 46.14		CADH5_HUMAN (1-784): 0: 805: 100.00
+	Mm
		723722 CTND1_MOUSE (1-933): 0: 773: 46.39		CADH5_MOUSE (1-783): 0: 760: 75.29
+	Mm
		749747 ARVC_MOUSE (1-962): 0: 879: 91.60		CAD15_MOUSE (31-777): 0: 613: 30.57
+	Hs
		125886 ARVC_HUMAN (1-962): 0: 869: 100.00		CAD15_HUMAN (15-776): 0: 612: 32.12
+	Mm
		486818 ARVC_MOUSE (1-962): 0: 879: 91.60		CADH1_MOUSE (25-780): 0: 581: 30.99
+	Hs
		125874 ARVC_HUMAN (1-962): 0: 869: 100.00		CADH1_HUMAN (26-780): 0: 588: 31.71
+	Hs
		254176 CTND1_HUMAN (1-933): 0: 750: 46.14		CAD24_HUMAN (1-782): 0: 688: 36.39
+	Mm
		486812 CTND1_MOUSE (1-933): 0: 773: 46.39		CADH1_MOUSE (25-780): 0: 581: 30.99
+	Hs
		254035 CTND1_HUMAN (1-933): 0: 750: 46.14		CADH1_HUMAN (26-780): 0: 588: 31.71
+	Hs
		254054 CTND1_HUMAN (1-933): 0: 750: 46.14		CADH3_HUMAN (32-780): 0: 573: 30.49
+	Hs
		125885 ARVC_HUMAN (1-962): 0: 869: 100.00		CAD12_HUMAN (1-469): 3.08e-89: 299: 23.46
+	Hs
		125884 ARVC_HUMAN (1-962): 0: 869: 100.00		CADH8_HUMAN (1-469): 2.69e-86: 292: 22.75
+	Mm
		580360 ARVC_MOUSE (1-962): 0: 879: 91.60		CADH2_MOUSE (1-469): 3.8e-62: 227: 20.83
+	Hs
		125876 ARVC_HUMAN (1-962): 0: 869: 100.00		CADH2_HUMAN (1-469): 5.01e-61: 223: 20.43
+	Hs
		556438 PKP3_HUMAN (19-852): 9.78e-160: 491: 26.20		CADH1_HUMAN (26-780): 0: 588: 31.71
+	Hs
		254100 CTND1_HUMAN (1-933): 0: 750: 46.14		CADH8_HUMAN (1-469): 2.69e-86: 292: 22.75
+	Mm
		580351 CTND1_MOUSE (1-933): 0: 773: 46.39		CADH2_MOUSE (1-469): 3.8e-62: 227: 20.83
+	Hs
		254101 CTND1_HUMAN (1-933): 0: 750: 46.14		CAD11_HUMAN (1-369): 2.6e-62: 225: 17.25
+	Hs
		254049 CTND1_HUMAN (1-933): 0: 750: 46.14		CADH2_HUMAN (1-469): 5.01e-61: 223: 20.43
+	Hs
		1064490 PKP3_HUMAN (19-852): 9.78e-160: 491: 26.20		DSC1_HUMAN (20-652): 2.46e-49: 189: 29.17