HitPredict

Interactor 1: BMAL1 (O00327)
Basic helix-loop-helix ARNT-like protein 1 (Aryl hydrocarbon receptor nuclear translocator-like protein 1) (Basic-helix-loop-helix-PAS protein MOP3) (Brain and muscle ARNT-like 1) (Class E basic helix-loop-helix protein 5) (bHLHe5) (Member of PAS protein 3) (PAS domain-containing protein 3) (bHLH-PAS protein JAP3)
Gene: BMAL1

Interactor 2: CRY1 (Q16526)
Cryptochrome-1
Gene: CRY1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.78 0.60 0.688

The method score is based on:

Property Details
Experiments 23555304, 25756610, 10531061, 28388406
Identification Methods affinity chromatography technology, two hybrid, anti bait coimmunoprecipitation
Interaction Type physical association, direct interaction, association

The annotation score is based on:

Property Details
Interacting Pfam domains -
Common GO terms GO:0003677 - DNA binding
GO:0005634 - nucleus
GO:0007623 - circadian rhythm
GO:0032922 - circadian regulation of gene expression
GO:0045892 - negative regulation of DNA-templated transcription
and 2 others

more...
Homologous interactions 18

Homologous interactions

Color coding for hit scores

1 626
Hs

1 586
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Last updated: 15 Jul 2024