HitPredict

Interactor 1: HS105 (Q92598)
Heat shock protein 105 kDa (Antigen NY-CO-25) (Heat shock 110 kDa protein) (Heat shock protein family H member 1)
Gene: HSPH1

Interactor 2: DNJB4 (Q9UDY4)
DnaJ homolog subfamily B member 4 (Heat shock 40 kDa protein 1 homolog) (HSP40 homolog) (Heat shock protein 40 homolog) (Human liver DnaJ-like protein)
Gene: DNAJB4

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.75	1.00	0.867

Property	Details
Experiments	33957083, 33961781, 35271311
Identification Methods	affinity chromatography technology, proximity labelling technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	DnaJ~HSP70
Common GO terms	GO:0005654 - nucleoplasm GO:0005829 - cytosol GO:0006986 - response to unfolded protein GO:0051085 - chaperone cofactor-dependent protein refolding
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 858 Hs			1 337
+	Hs
		1123860 HS105_HUMAN (1-858): 0: 1004: 100.00		Q59E89_HUMAN (1-337): 1.44e-137: 395: 99.70
+	Hs
		279330 HS105_HUMAN (1-858): 0: 1004: 100.00		DNJB5_HUMAN (1-337): 1.41e-131: 380: 60.92
+	Hs
		636386 HS105_HUMAN (1-858): 0: 1004: 100.00		DNJB1_HUMAN (1-335): 7.26e-127: 368: 64.60
+	Hs
		681540 HS105_HUMAN (1-858): 0: 1004: 100.00		DNJA1_HUMAN (5-335): 9.73e-119: 349: 32.17
+	Hs
		320814 HS74L_HUMAN (1-858): 0: 953: 57.46		DNJB1_HUMAN (1-335): 7.26e-127: 368: 64.60
+	Hs
		714449 HSP74_HUMAN (1-858): 0: 917: 60.98		DNJB4_HUMAN (1-337): 9.06e-140: 400: 100.00
+	Hs
		279281 HSP74_HUMAN (1-858): 0: 917: 60.98		DNJB5_HUMAN (1-337): 1.41e-131: 380: 60.92
+	Hs
		636257 HSP74_HUMAN (1-858): 0: 917: 60.98		DNJB1_HUMAN (1-335): 7.26e-127: 368: 64.60
+	Dm
		1096122 Q9VUC1_DROME (1-844): 0: 821: 42.13		DNAJ1_DROME (1-335): 6.88e-117: 342: 54.87
+	Hs
		714326 HSP74_HUMAN (1-858): 0: 917: 60.98		DNJB3_HUMAN (4-108): 5.57e-28: 108: 55.56
+	Sc
		633055 HSP7F_YEAST (5-730): 7.71e-136: 422: 36.92		MAS5_YEAST (5-336): 1.57e-111: 331: 30.60
+	Sc
		633056 HSP79_YEAST (5-730): 3.81e-130: 407: 34.89		MAS5_YEAST (5-336): 1.57e-111: 331: 30.60
+	Sc
		627838 HSP7F_YEAST (5-730): 7.71e-136: 422: 36.92		SIS1_YEAST (6-334): 1.26e-53: 181: 33.69
+	Sc
		627839 HSP79_YEAST (5-730): 3.81e-130: 407: 34.89		SIS1_YEAST (6-334): 1.26e-53: 181: 33.69
+	Hs
		1354295 HYOU1_HUMAN (1-839): 2.83e-81: 284: 27.41		DJB11_HUMAN (2-334): 6.07e-99: 298: 31.34
+	Hs
		279272 HSP7C_HUMAN (489-709): 2.48e-32: 135: 11.26		DNJB5_HUMAN (1-337): 1.41e-131: 380: 60.92
+	Hs
		503463 HSP7C_HUMAN (489-709): 2.48e-32: 135: 11.26		DNJB1_HUMAN (1-335): 7.26e-127: 368: 64.60
+	Hs
		243275 HSP7C_HUMAN (489-709): 2.48e-32: 135: 11.26		DNJA2_HUMAN (2-336): 8.37e-120: 353: 31.46
+	Hs
		503527 HSP7C_HUMAN (489-709): 2.48e-32: 135: 11.26		DNJA1_HUMAN (5-335): 9.73e-119: 349: 32.17
+	Hs
		504474 HSP7C_HUMAN (489-709): 2.48e-32: 135: 11.26		DNJB3_HUMAN (4-108): 5.57e-28: 108: 55.56