HitPredict

Interactor 1: SHIP1 (Q92835)
Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1 (EC 3.1.3.86) (Inositol polyphosphate-5-phosphatase D) (EC 3.1.3.56) (Inositol polyphosphate-5-phosphatase of 145 kDa) (SIP-145) (Phosphatidylinositol 4,5-bisphosphate 5-phosphatase) (EC 3.1.3.36) (SH2 domain-containing inositol 5'-phosphatase 1) (SH2 domain-containing inositol phosphatase 1) (SHIP-1) (p150Ship) (hp51CN)
Gene: INPP5D

Interactor 2: CD244 (Q9BZW8)
Natural killer cell receptor 2B4 (NK cell activation-inducing ligand) (NAIL) (NK cell type I receptor protein 2B4) (NKR2B4) (h2B4) (SLAM family member 4) (SLAMF4) (Signaling lymphocytic activation molecule 4) (CD antigen CD244)
Gene: CD244

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.65	0.60	0.625

Property	Details
Experiments	26221972, 24642916
Identification Methods	surface plasmon resonance, pull down
Interaction Type	direct interaction, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005886 - plasma membrane GO:0007165 - signal transduction
Homologous interactions	12

Homologous interactions

Color coding for hit scores

	1 1189 Hs			1 370
+	Hs
		1271567 SHIP1_HUMAN (1-1189): 0: 883: 100.00		SLAF7_HUMAN (1-345): 9.95e-51: 174: 18.29
+	Mm
		1322348 SHIP1_MOUSE (1-1189): 0: 858: 87.11		SLAF1_MOUSE (6-325): 2.31e-60: 199: 19.41
+	Hs
		1271566 SHIP1_HUMAN (1-1189): 0: 883: 100.00		LY9_HUMAN (4-238): 1.56e-46: 169: 21.25
+	Hs
		1030743 SHIP1_HUMAN (1-1189): 0: 883: 100.00		SLAF1_HUMAN (1-324): 1.26e-48: 168: 19.29
+	Hs
		176495 SHIP2_HUMAN (3-1169): 0: 697: 39.77		CD244_HUMAN (1-370): 8.84e-97: 294: 100.00
+	Hs
		243155 SH21A_HUMAN (7-101): 2.92e-20: 89.7: 45.26		CD244_HUMAN (1-370): 8.84e-97: 294: 100.00
+	Hs
		243161 SH21A_HUMAN (7-101): 2.92e-20: 89.7: 45.26		SLAF5_HUMAN (2-345): 8.99e-63: 205: 21.57
+	Mm
		292400 SH21A_MOUSE (7-116): 3.21e-22: 95.1: 44.55		SLAF1_MOUSE (6-325): 2.31e-60: 199: 19.41
+	Hs
		243153 SH21A_HUMAN (7-101): 2.92e-20: 89.7: 45.26		SLAF6_HUMAN (2-332): 1.88e-56: 189: 18.71
+	Hs
		243158 SH21A_HUMAN (7-101): 2.92e-20: 89.7: 45.26		SLAF7_HUMAN (1-345): 9.95e-51: 174: 18.29
+	Hs
		243157 SH21A_HUMAN (7-101): 2.92e-20: 89.7: 45.26		LY9_HUMAN (4-238): 1.56e-46: 169: 21.25
+	Hs
		243137 SH21A_HUMAN (7-101): 2.92e-20: 89.7: 45.26		SLAF1_HUMAN (1-324): 1.26e-48: 168: 19.29