HitPredict

Interactor 1: NFKB1 (Q94527)
Nuclear factor NF-kappa-B p110 subunit (Rel-p110) (Relish protein) [Cleaved into: Nuclear factor NF-kappa-B p68 subunit (Rel-p68); Nuclear factor NF-kappa-B p49 subunit (Rel-p49)]
Gene: Rel

Interactor 2: IKKB (Q9VEZ5)
Inhibitor of nuclear factor kappa-B kinase subunit beta (I-kappaB kinase subunit beta) (EC 2.7.11.10) (Cactus kinase IKK) (IKK-like protein) (Immune response deficient protein 5) (Lipopolysaccharide-activated kinase) (DLAK)
Gene: IKKbeta

Species: Drosophila melanogaster

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.74 1.00 0.861

The method score is based on:

Property Details
Experiments 19497884, 25242320, 22036573
Identification Methods enzymatic study, affinity chromatography technology, protein kinase assay
Interaction Type direct interaction, physical association, phosphorylation reaction

The annotation score is based on:

Property Details
Interacting Pfam domains Ank_2~Pkinase
Common GO terms GO:0002230 - positive regulation of defense response to virus by host
GO:0005737 - cytoplasm
GO:0005829 - cytosol
GO:0006963 - positive regulation of antibacterial peptide biosynthetic process
GO:0045087 - innate immune response
and 5 others

more...
Homologous interactions 20

Homologous interactions (Top 20)

Color coding for hit scores

1 971
Dm

1 751
+ Dm
+ Hs
+ Hs
+ Hs
+ Hs
+ Hs
+ Rn
+ Hs
+ Hs
+ Hs
+ Hs
+ Mm
+ Hs
+ Hs
+ Hs
+ Hs
+ Hs
+ Hs
+ Hs
+ Hs

Service provided by Combinatics, Japan

Last updated: 15 Jul 2024