Protein: DTX3
Probable E3 ubiquitin-protein ligase DTX3 (EC 2.3.2.27) (Protein deltex-3) (Deltex3) (RING finger protein 154) (RING-type E3 ubiquitin transferase DTX3)

Gene: DTX3
Organism: Homo sapiens
Interactions: 123
UniProt ID: Q8N9I9

Gene Ontology (top 5):
GO:0005654 - nucleoplasm
GO:0005737 - cytoplasm
GO:0007219 - Notch signaling pathway
GO:0008270 - zinc ion binding
GO:0016567 - protein ubiquitination

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

957629

UBE2K
Ubiquitin-conjugating enzyme E2 K

4

20

High-throughput

0.904

High

1331927

RN114
E3 ubiquitin-protein ligase RNF114

4

2

High-throughput

0.892

High

168550

UB2L6
Ubiquitin/ISG15-conjugating enzyme E2 L6

3

20

High-throughput

0.861

High

906708

UB2D1
Ubiquitin-conjugating enzyme E2 D1

3

20

High-throughput

0.861

High

957133

UB2D3
Ubiquitin-conjugating enzyme E2 D3

3

20

High-throughput

0.861

High

1331913

TRAF4
TNF receptor-associated factor 4

3

1

High-throughput

0.861

High

1331925

UB2D4
Ubiquitin-conjugating enzyme E2 D4

3

20

High-throughput

0.861

High

1331910

CHFR
E3 ubiquitin-protein ligase CHFR

4

0

High-throughput

0.846

High

982247

UB2D2
Ubiquitin-conjugating enzyme E2 D2

2

20

High-throughput

0.800

High

995995

UB2L3
Ubiquitin-conjugating enzyme E2 L3

2

20

High-throughput

0.800

High

909351

UB2E1
Ubiquitin-conjugating enzyme E2 E1

1

20

High-throughput

0.698

High

1103916

UB2V1
Ubiquitin-conjugating enzyme E2 variant 1

1

20

High-throughput

0.698

High

1331904

UB2E3
Ubiquitin-conjugating enzyme E2 E3

1

20

High-throughput

0.698

High

1331905

UBE2W
Ubiquitin-conjugating enzyme E2 W

1

20

High-throughput

0.698

High

1154129

ITSN1
Intersectin-1

4

3

High-throughput

0.691

High

853826

MK09
Mitogen-activated protein kinase 9

4

0

High-throughput

0.663

High

288466

UBP2
Ubiquitin carboxyl-terminal hydrolase 2

3

5

High-throughput

0.654

High

957792

UBE2N
Ubiquitin-conjugating enzyme E2 N

1

20

Small-scale

0.647

High

1331908

NMD3
60S ribosomal export protein NMD3

3

0

High-throughput

0.638

High

970785

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

20

High-throughput

0.625

High

1331911

UB2E2
Ubiquitin-conjugating enzyme E2 E2

1

20

High-throughput

0.625

High

1331918

SYFB
Phenylalanine--tRNA ligase beta subunit

3

0

High-throughput

0.622

High

623444

RO52
E3 ubiquitin-protein ligase TRIM21

1

1

Small-scale

0.618

High

440634

FYN
Tyrosine-protein kinase Fyn

2

8

High-throughput

0.615

High

222149

NCK2
Cytoplasmic protein NCK2

2

9

High-throughput

0.606

High

943796

UBS3A
Ubiquitin-associated and SH3 domain-containing protein A

2

6

High-throughput

0.606

High

987779

GRB2
Growth factor receptor-bound protein 2

2

9

High-throughput

0.606

High

1118415

PTK6
Protein-tyrosine kinase 6

2

8

High-throughput

0.606

High

1150878

CIP4
Cdc42-interacting protein 4

2

2

High-throughput

0.606

High

1331900

UBS3B
Ubiquitin-associated and SH3 domain-containing protein B

2

6

High-throughput

0.606

High

1331917

PAR11
Protein mono-ADP-ribosyltransferase PARP11

2

5

High-throughput

0.606

High

1331924

GUAD
Guanine deaminase

2

0

High-throughput

0.602

High

1331922

PARP2
Poly [ADP-ribose] polymerase 2

2

3

High-throughput

0.601

High

347813

BAG3
BAG family molecular chaperone regulator 3

2

0

High-throughput

0.580

High

1015064

ARF5
ADP-ribosylation factor 5

2

0

High-throughput

0.580

High

1331909

ZMY19
Zinc finger MYND domain-containing protein 19

2

0

High-throughput

0.580

High

1127735

HLTF
Helicase-like transcription factor

1

3

High-throughput

0.575

High

463163

YES
Tyrosine-protein kinase Yes

2

8

High-throughput

0.553

High

1331899

IKBD
NF-kappa-B inhibitor delta

2

1

High-throughput

0.553

High

1047639

NOTC2
Neurogenic locus notch homolog protein 2

1

7

Small-scale

0.552

High

1022749

XIAP
E3 ubiquitin-protein ligase XIAP

1

1

High-throughput

0.541

High

1331914

RNF38
E3 ubiquitin-protein ligase RNF38

1

3

High-throughput

0.541

High

1331902

RAD50
DNA repair protein RAD50

1

5

High-throughput

0.536

High

75517

B3KSH4
Huntingtin interacting protein 2, isoform CRA_a

1

20

High-throughput

0.528

High

1310068

U2D2L
Putative ubiquitin-conjugating enzyme E2 D2-like protein

1

20

High-throughput

0.528

High

1331901

RN141
RING finger protein 141

1

0

High-throughput

0.518

High

1279642

SPRE1
Sprouty-related, EVH1 domain-containing protein 1

1

1

High-throughput

0.515

High

1331915

GGNB2
Gametogenetin-binding protein 2

1

0

High-throughput

0.513

High

931967

EPHB4
Ephrin type-B receptor 4

1

1

Small-scale

0.512

High

1307572

ZDH17
Palmitoyltransferase ZDHHC17

1

2

High-throughput

0.494

High

317196

UBP1
Ubiquitin carboxyl-terminal hydrolase 1

1

1

High-throughput

0.481

High

1331923

UBP21
Ubiquitin carboxyl-terminal hydrolase 21

1

4

High-throughput

0.481

High

278124

FLNB
Filamin-B

1

4

Small-scale

0.479

High

414223

P53
Cellular tumor antigen p53

1

4

Small-scale

0.479

High

461709

HS90A
Heat shock protein HSP 90-alpha

1

6

Small-scale

0.479

High

463654

LYN
Tyrosine-protein kinase Lyn

1

8

Small-scale

0.479

High

485270

ROA1
Heterogeneous nuclear ribonucleoprotein A1

1

4

Small-scale

0.479

High

487538

PARP1
Poly [ADP-ribose] polymerase 1

1

9

Small-scale

0.479

High

559419

XRCC5
X-ray repair cross-complementing protein 5

1

2

Small-scale

0.479

High

637636

FLNA
Filamin-A

1

4

Small-scale

0.479

High

729354

HNRH1
Heterogeneous nuclear ribonucleoprotein H

1

5

Small-scale

0.479

High

762468

PROF2
Profilin-2

1

1

Small-scale

0.479

High

785298

RL4
Large ribosomal subunit protein uL4

1

1

Small-scale

0.479

High

794547

RBMX
RNA-binding motif protein, X chromosome

1

1

Small-scale

0.479

High

934862

TERA
Transitional endoplasmic reticulum ATPase

1

3

Small-scale

0.479

High

992858

RACK1
Small ribosomal subunit protein RACK1

1

2

Small-scale

0.479

High

1028818

SPTB2
Spectrin beta chain, non-erythrocytic 1

1

1

Small-scale

0.479

High

1113711

CUL3
Cullin-3

1

2

High-throughput

0.479

High

1125364

FLNC
Filamin-C

1

4

Small-scale

0.479

High

1331897

PDZD8
PDZ domain-containing protein 8

1

1

Small-scale

0.479

High

179375

ARPC2
Actin-related protein 2/3 complex subunit 2

1

0

Small-scale

0.458

High

336456

SVIL
Supervillin

1

0

Small-scale

0.458

High

565975

EF2
Elongation factor 2

1

0

Small-scale

0.458

High

612703

RL7
Large ribosomal subunit protein uL30

1

0

Small-scale

0.458

High

716444

PRDX5
Peroxiredoxin-5, mitochondrial

1

0

Small-scale

0.458

High

716909

RL12
Large ribosomal subunit protein uL11

1

0

Small-scale

0.458

High

788101

ODO2
Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial

1

0

Small-scale

0.458

High

862909

IQGA1
Ras GTPase-activating-like protein IQGAP1

1

0

Small-scale

0.458

High

969312

RS8
Small ribosomal subunit protein eS8

1

0

Small-scale

0.458

High

973236

RS13
Small ribosomal subunit protein uS15

1

0

Small-scale

0.458

High

975806

RL7A
Large ribosomal subunit protein eL8

1

0

Small-scale

0.458

High

981588

RAN
GTP-binding nuclear protein Ran

1

0

Small-scale

0.458

High

1008242

PRKDC
DNA-dependent protein kinase catalytic subunit

1

0

Small-scale

0.458

High

1027592

HNRPU
Heterogeneous nuclear ribonucleoprotein U

1

0

Small-scale

0.458

High

1068264

AHNK
Neuroblast differentiation-associated protein AHNAK

1

0

Small-scale

0.458

High

1331926

MYO5A
Unconventional myosin-Va

1

0

Small-scale

0.458

High

589171

RFA2
Replication protein A 32 kDa subunit

1

2

High-throughput

0.445

High

617715

XRCC1
DNA repair protein XRCC1

1

1

High-throughput

0.445

High

768655

RFA3
Replication protein A 14 kDa subunit

1

2

High-throughput

0.445

High

839798

EPS15
Epidermal growth factor receptor substrate 15

1

2

High-throughput

0.445

High

1122938

WRN
Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN

1

2

High-throughput

0.445

High

1292491

CHD1L
Chromodomain-helicase-DNA-binding protein 1-like

1

1

High-throughput

0.445

High

1331898

NUP35
Nucleoporin NUP35

1

1

High-throughput

0.445

High

1331920

EP15R
Epidermal growth factor receptor substrate 15-like 1

1

4

High-throughput

0.445

High

1331903

OSTF1
Osteoclast-stimulating factor 1

1

2

High-throughput

0.439

High

443884

ATPB
ATP synthase F(1) complex subunit beta, mitochondrial

1

2

Small-scale

0.437

High

680432

ATPA
ATP synthase F(1) complex subunit alpha, mitochondrial

1

2

Small-scale

0.437

High

882781

EFTU
Elongation factor Tu, mitochondrial

1

2

Small-scale

0.437

High

1024407

S25A3
Solute carrier family 25 member 3

1

1

Small-scale

0.437

High

1026133

CLH1
Clathrin heavy chain 1

1

1

Small-scale

0.437

High

1331919

RRBP1
Ribosome-binding protein 1

1

4

Small-scale

0.437

High

230068

SAHH2
S-adenosylhomocysteine hydrolase-like protein 1

1

0

High-throughput

0.426

High

340006

RPA1
DNA-directed RNA polymerase I subunit RPA1

1

0

High-throughput

0.426

High

892595

DNLI3
DNA ligase 3

1

0

High-throughput

0.426

High

1331912

PNKP
Bifunctional polynucleotide phosphatase/kinase

1

0

High-throughput

0.426

High

131470

EIF3F
Eukaryotic translation initiation factor 3 subunit F

1

4

High-throughput

0.407

High

292693

RENR
Renin receptor

1

1

High-throughput

0.407

High

1331906

SO4A1
Solute carrier organic anion transporter family member 4A1

1

2

High-throughput

0.407

High

1331921

DJB11
DnaJ homolog subfamily B member 11

1

1

High-throughput

0.407

High

1216266

NDUF5
Arginine-hydroxylase NDUFAF5, mitochondrial

4

0

Small-scale

0.362

High

1331916

CIAO3
Cytosolic iron-sulfur assembly component 3

3

0

High-throughput

0.347

High

278699

NDUS6
NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial

2

0

High-throughput

0.318

High

1272779

EPMIP
EPM2A-interacting protein 1

2

0

High-throughput

0.316

High

1295065

F90A1
Protein FAM90A1

2

0

High-throughput

0.316

High

1331065

TEANC
Transcription elongation factor A N-terminal and central domain-containing protein

2

0

High-throughput

0.316

High

1311671

UEVLD
Ubiquitin-conjugating enzyme E2 variant 3

1

0

High-throughput

0.282

High

573977

MYL6B
Myosin light chain 6B

1

0

Small-scale

0.249

Low

581169

RAC2
Ras-related C3 botulinum toxin substrate 2

1

0

Small-scale

0.249

Low

626007

ITIH2
Inter-alpha-trypsin inhibitor heavy chain H2

1

0

Small-scale

0.249

Low

1124861

FLOT2
Flotillin-2

1

0

Small-scale

0.249

Low

1131319

GANAB
Neutral alpha-glucosidase AB

1

0

Small-scale

0.249

Low

1164468

MIC60
MICOS complex subunit MIC60

1

0

Small-scale

0.249

Low

1331907

EFHD2
EF-hand domain-containing protein D2

1

0

Small-scale

0.249

Low


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Last updated: 11Aug2025