HitPredict

Interactor 1: H2B1A (Q96A08)
Histone H2B type 1-A (Histone H2B, testis) (TSH2B.1) (hTSH2B) (Testis-specific histone H2B)
Gene: H2BC1

Interactor 2: RUVB1 (Q9Y265)
RuvB-like 1 (EC 3.6.4.12) (49 kDa TATA box-binding protein-interacting protein) (49 kDa TBP-interacting protein) (54 kDa erythrocyte cytosolic protein) (ECP-54) (INO80 complex subunit H) (Nuclear matrix protein 238) (NMP 238) (Pontin 52) (TIP49a) (TIP60-associated protein 54-alpha) (TAP54-alpha)
Gene: RUVBL1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.74	0.60	0.667

Property	Details
Experiments	26186194, 28514442, 33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000786 - nucleosome GO:0005634 - nucleus GO:0005654 - nucleoplasm
Homologous interactions	13

Homologous interactions

Color coding for hit scores

	1 127 Hs			1 456
+	Hs
		1087495 H2B2E_HUMAN (1-127): 4.39e-54: 167: 85.83		RUVB1_HUMAN (1-456): 0: 704: 100.00
+	Hs
		707797 H2B1B_HUMAN (1-127): 6.87e-54: 166: 85.83		RUVB1_HUMAN (1-456): 0: 704: 100.00
+	Hs
		918779 H2B1C_HUMAN (1-127): 8.19e-54: 166: 85.04		RUVB1_HUMAN (1-456): 0: 704: 100.00
+	Hs
		1231264 H2B3B_HUMAN (1-127): 8.98e-51: 158: 85.83		RUVB1_HUMAN (1-456): 0: 704: 100.00
+	Hs
		1129867 H2B2F_HUMAN (5-127): 1.83e-54: 168: 85.37		RUVB2_HUMAN (2-455): 0: 651: 42.76
+	Hs
		1087493 H2B2E_HUMAN (1-127): 4.39e-54: 167: 85.83		RUVB2_HUMAN (2-455): 0: 651: 42.76
+	Hs
		707796 H2B1B_HUMAN (1-127): 6.87e-54: 166: 85.83		RUVB2_HUMAN (2-455): 0: 651: 42.76
+	Hs
		886220 H2B1D_HUMAN (1-127): 1.37e-53: 166: 85.04		RUVB2_HUMAN (2-455): 0: 651: 42.76
+	Hs
		918777 H2B1C_HUMAN (1-127): 8.19e-54: 166: 85.04		RUVB2_HUMAN (2-455): 0: 651: 42.76
+	Hs
		1282982 H2B1A_HUMAN (1-127): 1.72e-52: 163: 100.00		RUVB2_HUMAN (2-455): 0: 651: 42.76
+	Dm
		355271 H2B_DROME (37-127): 3.48e-47: 149: 94.51		RUVB1_DROME (1-455): 0: 660: 79.56
+	Sc
		355997 H2B2_YEAST (4-126): 4.46e-41: 134: 69.36		RUVB1_YEAST (1-455): 0: 652: 67.39
+	Sc
		356054 H2B2_YEAST (4-126): 4.46e-41: 134: 69.36		RUVB2_YEAST (5-455): 0: 627: 41.72