Protein: HMDH1
3-hydroxy-3-methylglutaryl-coenzyme A reductase 1 (HMG-CoA reductase 1) (EC 1.1.1.34)

Gene: HMDH1, HMG1
Organism: Saccharomyces cerevisiae S288C
Interactions: 103
UniProt ID: P12683

Gene Ontology (top 5):
GO:0004420 - hydroxymethylglutaryl-CoA reductase (NADPH) activity
GO:0005635 - nuclear envelope
GO:0005778 - peroxisomal membrane
GO:0005783 - endoplasmic reticulum
GO:0005789 - endoplasmic reticulum membrane

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

520215

HMDH2
3-hydroxy-3-methylglutaryl-coenzyme A reductase 2

4

2

High-throughput

0.882

High

520259

NSG1
Protein NSG1

2

1

High-throughput

0.793

High

520214

HMDH1
3-hydroxy-3-methylglutaryl-coenzyme A reductase 1

2

2

High-throughput

0.743

High

520244

OSTB
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit WBP1

2

1

High-throughput

0.614

High

520254

PHO88
SRP-independent targeting protein 3

2

1

High-throughput

0.614

High

520267

ELO3
Fatty acid elongase 3

2

1

High-throughput

0.614

High

520268

SNL1
HSP70 co-chaperone SNL1

2

0

High-throughput

0.588

High

520252

NU170
Nucleoporin NUP170

2

1

High-throughput

0.584

High

520250

SRPB
Signal recognition particle receptor subunit beta

1

1

High-throughput

0.541

High

520290

HRD3
ERAD-associated E3 ubiquitin-protein ligase component HRD3

1

1

Small-scale

0.536

High

520293

HRD1
ERAD-associated E3 ubiquitin-protein ligase HRD1

1

4

Small-scale

0.536

High

426496

GPT
UDP-N-acetylglucosamine--dolichyl-phosphate N-acetylglucosaminephosphotransferase

1

0

High-throughput

0.518

High

520235

IRE1
Serine/threonine-protein kinase/endoribonuclease IRE1

1

0

High-throughput

0.518

High

520255

MKAR
Very-long-chain 3-oxoacyl-CoA reductase

1

0

High-throughput

0.518

High

520281

ERG25
C-4 methylsterol oxidase ERG25

1

0

High-throughput

0.518

High

520260

WSS1
DNA-dependent metalloprotease WSS1

1

0

Small-scale

0.480

High

410287

SC160
Protein SCP160

1

1

High-throughput

0.479

High

520221

ACO1
Acyl-CoA desaturase 1

1

1

High-throughput

0.479

High

520222

SEC62
Translocation protein SEC62

1

2

High-throughput

0.479

High

520226

ERG4
Delta(24(24(1)))-sterol reductase ERG4

1

2

High-throughput

0.479

High

520228

EMC1
ER membrane protein complex subunit 1

1

1

High-throughput

0.479

High

520229

CWH43
Protein CWH43

1

1

High-throughput

0.479

High

520234

PMT2
Dolichyl-phosphate-mannose--protein mannosyltransferase 2

1

5

High-throughput

0.479

High

520236

ERG24
Delta(14)-sterol reductase ERG24

1

2

High-throughput

0.479

High

520239

EMP24
Endosomal protein P24B

1

1

High-throughput

0.479

High

520243

SEC66
Translocation protein SEC66

1

1

High-throughput

0.479

High

520245

PMT1
Dolichyl-phosphate-mannose--protein mannosyltransferase 1

1

5

High-throughput

0.479

High

520248

YET1
Endoplasmic reticulum transmembrane protein 1

1

3

High-throughput

0.479

High

520251

GPT2
Glycerol-3-phosphate O-acyltransferase 2

1

1

High-throughput

0.479

High

520262

PO152
Nucleoporin POM152

1

1

High-throughput

0.479

High

520263

SPF1
Endoplasmic reticulum transmembrane helix translocase

1

1

High-throughput

0.479

High

520266

SCS2
Vesicle-associated membrane protein-associated protein SCS2

1

1

High-throughput

0.479

High

520272

ALG2
Alpha-1,3/1,6-mannosyltransferase ALG2

1

1

High-throughput

0.479

High

520274

PMT4
Dolichyl-phosphate-mannose--protein mannosyltransferase 4

1

5

High-throughput

0.479

High

520276

MPS3
Spindle pole body assembly component MPS3

1

1

High-throughput

0.479

High

520280

HLJ1
Protein HLJ1

1

1

High-throughput

0.479

High

520285

ALG9
Alpha-1,2-mannosyltransferase ALG9

1

1

High-throughput

0.479

High

520286

APJ1
J domain-containing protein APJ1

1

1

High-throughput

0.479

High

520287

OSTD
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit SWP1

1

1

High-throughput

0.479

High

520291

YET3
Endoplasmic reticulum transmembrane protein 3

1

3

High-throughput

0.479

High

520301

PGA3
Plasma membrane-associated coenzyme Q6 reductase PGA3

1

1

High-throughput

0.479

High

520217

SEC63
Protein translocation protein SEC63

1

0

High-throughput

0.458

High

520242

PLSC
1-acyl-sn-glycerol-3-phosphate acyltransferase

1

0

High-throughput

0.458

High

520246

NIC96
Nucleoporin NIC96

1

0

High-throughput

0.458

High

520256

SSH1
Sec sixty-one protein homolog

1

0

High-throughput

0.458

High

520261

STT3
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3

1

0

High-throughput

0.458

High

520269

LCB2
Serine palmitoyltransferase 2

1

0

High-throughput

0.458

High

520273

PHO86
Inorganic phosphate transporter PHO86

1

0

High-throughput

0.458

High

520277

EMC2
ER membrane protein complex subunit 2

1

0

High-throughput

0.458

High

520278

STE24
CAAX prenyl protease 1

1

0

High-throughput

0.458

High

520283

ERV14
ER-derived vesicles protein ERV14

1

0

High-throughput

0.458

High

520289

GSF2
Glucose-signaling factor 2

1

0

High-throughput

0.458

High

477091

UBI4P
Polyubiquitin [Cleaved into: Ubiquitin]

1

3

High-throughput

0.457

High

454145

TBA1
Tubulin alpha-1 chain

1

1

High-throughput

0.445

High

423740

ATPA
ATP synthase subunit alpha, mitochondrial

1

2

High-throughput

0.437

High

520218

HSC82
ATP-dependent molecular chaperone HSC82

1

1

High-throughput

0.437

High

520225

SIS1
Protein SIS1

1

1

High-throughput

0.437

High

520230

RL16A
Large ribosomal subunit protein uL13A

1

1

High-throughput

0.437

High

520247

YKK0
Probable intramembrane protease YKL100C

1

1

High-throughput

0.437

High

520288

SCC2
Sister chromatid cohesion protein 2

1

1

High-throughput

0.437

High

520297

TMA46
Translation machinery-associated protein 46

1

1

High-throughput

0.437

High

520258

RPN1
26S proteasome regulatory subunit RPN1

1

0

High-throughput

0.426

High

520275

MNN11
Probable alpha-1,6-mannosyltransferase MNN11

1

0

High-throughput

0.426

High

520279

LCF4
Long-chain-fatty-acid--CoA ligase 4

1

0

High-throughput

0.426

High

333676

ADH1
Alcohol dehydrogenase 1

1

1

High-throughput

0.407

High

367667

EF1A
Elongation factor 1-alpha

1

1

High-throughput

0.407

High

493042

HSP72
Heat shock protein SSA2

1

1

High-throughput

0.407

High

510064

SSB1
Ribosome-associated molecular chaperone SSB1

1

1

High-throughput

0.407

High

520219

VATB
V-type proton ATPase subunit B

1

2

High-throughput

0.407

High

520233

XPO1
Exportin-1

1

1

High-throughput

0.407

High

520241

PRS7
26S proteasome regulatory subunit 7 homolog

1

2

High-throughput

0.407

High

520253

OLA1
Obg-like ATPase 1

1

1

High-throughput

0.407

High

520265

IMB4
Importin subunit beta-4

1

1

High-throughput

0.407

High

520270

MPG1
Mannose-1-phosphate guanyltransferase

1

1

High-throughput

0.407

High

520271

GCN20
Protein GCN20

1

1

High-throughput

0.407

High

520238

SLA1
Actin cytoskeleton-regulatory complex protein SLA1

1

0

High-throughput

0.282

High

520282

VPS73
Vacuolar protein sorting-associated protein 73

1

0

High-throughput

0.282

High

520284

TNA1
High-affinity nicotinic acid transporter

1

0

High-throughput

0.282

High

520292

SPO75
Sporulation-specific protein 75

1

0

High-throughput

0.282

High

520296

YP264
Probable transport protein YPL264C

1

0

High-throughput

0.282

High

520227

RAD51
DNA repair protein RAD51

1

0

High-throughput

0.279

Low

357186

RMAR
Small ribosomal subunit protein uS3m

1

0

High-throughput

0.249

Low

471730

RL27A
Large ribosomal subunit protein eL27A

1

0

High-throughput

0.249

Low

477835

HSP77
Import motor subunit, mitochondrial

1

0

High-throughput

0.249

Low

520216

CAF20
Cap-associated protein CAF20

1

0

High-throughput

0.249

Low

520223

RPC2
DNA-directed RNA polymerase III subunit RPC2

1

0

High-throughput

0.249

Low

520231

TF2B
Transcription initiation factor IIB

1

0

High-throughput

0.249

Low

520232

BMH1
Protein BMH1

1

0

High-throughput

0.249

Low

520237

HOG1
Mitogen-activated protein kinase HOG1

1

0

High-throughput

0.249

Low

520240

TIM23
Mitochondrial import inner membrane translocase subunit TIM23

1

0

High-throughput

0.249

Low

520249

CENPA
Histone H3-like centromeric protein CSE4

1

0

High-throughput

0.249

Low

520295

SGO1
Shugoshin

1

0

High-throughput

0.249

Low

520300

RUVB2
RuvB-like protein 2

1

0

High-throughput

0.249

Low

360711

TBB
Tubulin beta chain

1

0

High-throughput

0.232

Low

498414

METK1
S-adenosylmethionine synthase 1

1

0

High-throughput

0.232

Low

520220

RPB3
DNA-directed RNA polymerase II subunit RPB3

1

0

High-throughput

0.232

Low

520224

MPCP
Mitochondrial phosphate carrier protein

1

0

High-throughput

0.232

Low

520257

YHI0
Putative proline--tRNA ligase YHR020W

1

0

High-throughput

0.232

Low

520264

GEA2
ARF guanine-nucleotide exchange factor 2

1

0

High-throughput

0.232

Low

520294

ETT1
Enhancer of translation termination 1

1

0

High-throughput

0.232

Low

520298

HSP42
Heat shock protein 42

1

0

High-throughput

0.232

Low

520299

PAA1
Polyamine N-acetyltransferase 1

1

0

High-throughput

0.232

Low


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Last updated: 15 Jul 2024