HitPredict

Interactor 1: SH3K1 (Q96B97)
SH3 domain-containing kinase-binding protein 1 (CD2-binding protein 3) (CD2BP3) (Cbl-interacting protein of 85 kDa) (Human Src family kinase-binding protein 1) (HSB-1)
Gene: SH3KBP1

Interactor 2: ARAP1 (Q96P48)
Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 1 (Centaurin-delta-2) (Cnt-d2)
Gene: ARAP1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.94	1.00	0.972

Property	Details
Experiments	29589748, 32969198, 21275903, 28514442, 31980649, 33961781, 19531213, unassigned2173
Identification Methods	pull down, x-ray crystallography, affinity chromatography technology, two hybrid, anti tag coimmunoprecipitation
Interaction Type	direct interaction, association, physical association

Property	Details
Interacting Pfam domains	PH~SH3_9
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0005886 - plasma membrane GO:0007015 - actin filament organization GO:0008360 - regulation of cell shape
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 665 Hs			1 1450
+	Hs
		557775 NCK1_HUMAN (104-421): 1.23e-32: 131: 16.81		ARAP1_HUMAN (1-1450): 0: 1074: 100.00
+	Hs
		924798 GRB2_HUMAN (2-158): 6.97e-33: 128: 19.91		ARAP1_HUMAN (1-1450): 0: 1074: 100.00
+	Hs
		1262750 SH3K1_HUMAN (1-665): 8.63e-127: 391: 100.00		ARAP3_HUMAN (4-1430): 0: 788: 32.76
+	Hs
		1262768 CD2AP_HUMAN (1-664): 1.16e-98: 317: 32.22		ARAP3_HUMAN (4-1430): 0: 788: 32.76
+	Hs
		1172836 SH3K1_HUMAN (1-665): 8.63e-127: 391: 100.00		RHG27_HUMAN (696-1141): 5.37e-88: 309: 21.22
+	Hs
		195796 Q5JPT6_HUMAN (1-665): 8.63e-127: 391: 100.00		ASAP2_HUMAN (322-766): 7.55e-83: 296: 19.59
+	Hs
		195804 SH3K1_HUMAN (1-665): 8.63e-127: 391: 100.00		ASAP2_HUMAN (322-766): 7.55e-83: 296: 19.59
+	Hs
		1136563 SPD2A_HUMAN (1-631): 1.05e-46: 180: 14.72		AGAP1_HUMAN (223-767): 1.18e-86: 304: 13.96
+	Hs
		64651 NCK1_HUMAN (104-421): 1.23e-32: 131: 16.81		RHG32_HUMAN (647-1331): 2.29e-86: 314: 16.71
+	Hs
		64687 GRB2_HUMAN (2-158): 6.97e-33: 128: 19.91		RHG32_HUMAN (647-1331): 2.29e-86: 314: 16.71
+	Hs
		195783 NCK1_HUMAN (104-421): 1.23e-32: 131: 16.81		ASAP2_HUMAN (322-766): 7.55e-83: 296: 19.59
+	Hs
		195791 GRB2_HUMAN (2-158): 6.97e-33: 128: 19.91		ASAP2_HUMAN (322-766): 7.55e-83: 296: 19.59
+	Hs
		924686 GRB2_HUMAN (2-158): 6.97e-33: 128: 19.91		RHG12_HUMAN (595-1140): 4.27e-81: 288: 17.41
+	Hs
		924608 GRB2_HUMAN (2-158): 6.97e-33: 128: 19.91		Q1RLN5_HUMAN (617-1140): 1.42e-77: 276: 17.04
+	Hs
		195795 ITSN1_HUMAN (68-454): 2.48e-21: 101: 14.01		ASAP2_HUMAN (322-766): 7.55e-83: 296: 19.59
+	Hs
		200212 GRB2_HUMAN (2-158): 6.97e-33: 128: 19.91		SRGP3_HUMAN (623-1221): 8.56e-72: 264: 13.76
+	Hs
		551038 NCK1_HUMAN (104-421): 1.23e-32: 131: 16.81		CHIN_HUMAN (845-1139): 1.19e-70: 247: 22.37
+	Hs
		1078833 ITSN1_HUMAN (68-454): 2.48e-21: 101: 14.01		RHG31_HUMAN (938-1422): 2.55e-74: 275: 17.72
+	Hs
		557714 NCK1_HUMAN (104-421): 1.23e-32: 131: 16.81		RHG21_HUMAN (84-499): 2.61e-25: 116: 10.45
+	Hs
		924893 GRB2_HUMAN (2-158): 6.97e-33: 128: 19.91		RHG35_HUMAN (970-1118): 2.63e-20: 100: 36.91