HitPredict

Interactor 1: SH3K1 (Q96B97)
SH3 domain-containing kinase-binding protein 1 (CD2-binding protein 3) (CD2BP3) (Cbl-interacting protein of 85 kDa) (Human Src family kinase-binding protein 1) (HSB-1)
Gene: SH3KBP1

Interactor 2: SH3G3 (Q99963)
Endophilin-A3 (EEN-B2) (Endophilin-3) (SH3 domain protein 2C) (SH3 domain-containing GRB2-like protein 3)
Gene: SH3GL3

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.70	0.60	0.649

Property	Details
Experiments	11894096, 21900206
Identification Methods	two hybrid, pull down, affinity chromatography technology, coimmunoprecipitation
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 665 Hs			1 347
+	Hs
		1285180 SH3K1_HUMAN (1-665): 8.63e-127: 391: 100.00		SH3G2_HUMAN (1-347): 8.3e-86: 264: 65.91
+	Hs
		1285179 SH3K1_HUMAN (1-665): 8.63e-127: 391: 100.00		SH3G1_HUMAN (1-347): 7.8e-80: 249: 66.30
+	Mm
		1143925 SH3K1_MOUSE (1-665): 4.53e-118: 370: 87.59		SH3G2_MOUSE (1-347): 4.35e-85: 262: 65.63
+	Hs
		1285230 SH3K1_HUMAN (1-665): 8.63e-127: 391: 100.00		SHLB1_HUMAN (10-342): 1.46e-66: 215: 24.22
+	Hs
		1285199 SH3K1_HUMAN (1-665): 8.63e-127: 391: 100.00		SHLB2_HUMAN (10-342): 1.05e-58: 196: 20.57
+	Hs
		1307444 CD2AP_HUMAN (1-664): 1.16e-98: 317: 32.22		SH3G2_HUMAN (1-347): 8.3e-86: 264: 65.91
+	Hs
		1089305 SH3K1_HUMAN (1-665): 8.63e-127: 391: 100.00		RHG44_HUMAN (6-252): 4.15e-52: 186: 22.10
+	Hs
		1285232 SH3K1_HUMAN (1-665): 8.63e-127: 391: 100.00		3BP1_HUMAN (6-252): 2.26e-38: 146: 17.63
+	Hs
		1148382 SH3K1_HUMAN (1-665): 8.63e-127: 391: 100.00		RHG17_HUMAN (6-251): 2.42e-35: 138: 20.83
+	Hs
		1089312 CD2AP_HUMAN (1-664): 1.16e-98: 317: 32.22		RHG44_HUMAN (6-252): 4.15e-52: 186: 22.10
+	Hs
		1052363 CD2AP_HUMAN (1-664): 1.16e-98: 317: 32.22		SRC8_HUMAN (7-343): 2.64e-50: 177: 14.49
+	Hs
		1377711 CD2AP_HUMAN (1-664): 1.16e-98: 317: 32.22		3BP1_HUMAN (6-252): 2.26e-38: 146: 17.63
+	Hs
		1078886 SH3K1_HUMAN (1-665): 8.63e-127: 391: 100.00		ITSN1_HUMAN (253-341): 7.42e-12: 68.9: 23.60
+	Hs
		924773 SH3K1_HUMAN (1-665): 8.63e-127: 391: 100.00		GRB2_HUMAN (290-346): 9.93e-12: 65.5: 41.38
+	Hs
		1148393 CD2AP_HUMAN (1-664): 1.16e-98: 317: 32.22		RHG17_HUMAN (6-251): 2.42e-35: 138: 20.83
+	Hs
		1126372 SH3K1_HUMAN (1-665): 8.63e-127: 391: 100.00		SH319_HUMAN (291-342): 6.81e-09: 59.3: 48.08
+	Mm
		1141153 SH3K1_MOUSE (1-665): 4.53e-118: 370: 87.59		GRB2_MOUSE (292-346): 1.08e-11: 65.5: 42.86
+	Hs
		924988 CD2AP_HUMAN (1-664): 1.16e-98: 317: 32.22		GRB2_HUMAN (290-346): 9.93e-12: 65.5: 41.38
+	Mm
		1141167 CD2AP_MOUSE (1-663): 7.79e-83: 276: 31.53		GRB2_MOUSE (292-346): 1.08e-11: 65.5: 42.86
+	Hs
		924630 SPD2A_HUMAN (1-631): 1.05e-46: 180: 14.72		GRB2_HUMAN (290-346): 9.93e-12: 65.5: 41.38