HitPredict

Interactor 1: SH3K1 (Q96B97)
SH3 domain-containing kinase-binding protein 1 (CD2-binding protein 3) (CD2BP3) (Cbl-interacting protein of 85 kDa) (Human Src family kinase-binding protein 1) (HSB-1)
Gene: SH3KBP1

Interactor 2: SH3G2 (Q99962)
Endophilin-A1 (EEN-B1) (Endophilin-1) (SH3 domain protein 2A) (SH3 domain-containing GRB2-like protein 2)
Gene: SH3GL2

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.89	1.00	0.948

Property	Details
Experiments	11894095, 15456872, 25005938, 21900206, 16164598, 11894096
Identification Methods	two hybrid, pull down, affinity chromatography technology, anti tag coimmunoprecipitation, anti bait coimmunoprecipitation
Interaction Type	direct interaction, physical association, association

Property	Details
Interacting Pfam domains	SH3_2~SH3_9
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0005886 - plasma membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 665 Hs			1 352
+	Hs
		1285181 SH3K1_HUMAN (1-665): 8.63e-127: 391: 100.00		SH3G3_HUMAN (1-352): 1.25e-89: 274: 68.08
+	Mm
		1143925 SH3K1_MOUSE (1-665): 4.53e-118: 370: 87.59		SH3G2_MOUSE (1-352): 3.65e-95: 288: 98.86
+	Hs
		1285179 SH3K1_HUMAN (1-665): 8.63e-127: 391: 100.00		SH3G1_HUMAN (1-352): 1.41e-84: 262: 69.57
+	Hs
		1285230 SH3K1_HUMAN (1-665): 8.63e-127: 391: 100.00		SHLB1_HUMAN (10-347): 8.42e-72: 229: 24.50
+	Hs
		1307444 CD2AP_HUMAN (1-664): 1.16e-98: 317: 32.22		SH3G2_HUMAN (1-352): 6.15e-96: 290: 100.00
+	Hs
		1285199 SH3K1_HUMAN (1-665): 8.63e-127: 391: 100.00		SHLB2_HUMAN (10-347): 3.31e-62: 205: 21.35
+	Hs
		1089305 SH3K1_HUMAN (1-665): 8.63e-127: 391: 100.00		RHG44_HUMAN (6-252): 2.28e-51: 184: 21.35
+	Hs
		1148382 SH3K1_HUMAN (1-665): 8.63e-127: 391: 100.00		RHG17_HUMAN (6-256): 5.79e-38: 146: 21.56
+	Hs
		1285232 SH3K1_HUMAN (1-665): 8.63e-127: 391: 100.00		3BP1_HUMAN (6-260): 6.66e-38: 145: 17.48
+	Hs
		1052363 CD2AP_HUMAN (1-664): 1.16e-98: 317: 32.22		SRC8_HUMAN (7-348): 9.8e-53: 184: 14.83
+	Hs
		1089312 CD2AP_HUMAN (1-664): 1.16e-98: 317: 32.22		RHG44_HUMAN (6-252): 2.28e-51: 184: 21.35
+	Hs
		1148393 CD2AP_HUMAN (1-664): 1.16e-98: 317: 32.22		RHG17_HUMAN (6-256): 5.79e-38: 146: 21.56
+	Hs
		1377711 CD2AP_HUMAN (1-664): 1.16e-98: 317: 32.22		3BP1_HUMAN (6-260): 6.66e-38: 145: 17.48
+	Hs
		924773 SH3K1_HUMAN (1-665): 8.63e-127: 391: 100.00		GRB2_HUMAN (295-351): 1.51e-12: 67.8: 43.10
+	Hs
		1126372 SH3K1_HUMAN (1-665): 8.63e-127: 391: 100.00		SH319_HUMAN (296-347): 6.75e-10: 62.4: 55.77
+	Mm
		1141153 SH3K1_MOUSE (1-665): 4.53e-118: 370: 87.59		GRB2_MOUSE (295-351): 1.71e-12: 67.8: 43.10
+	Hs
		924988 CD2AP_HUMAN (1-664): 1.16e-98: 317: 32.22		GRB2_HUMAN (295-351): 1.51e-12: 67.8: 43.10
+	Hs
		1052222 SPD2A_HUMAN (1-631): 1.05e-46: 180: 14.72		SRC8_HUMAN (7-348): 9.8e-53: 184: 14.83
+	Mm
		1141167 CD2AP_MOUSE (1-663): 7.79e-83: 276: 31.53		GRB2_MOUSE (295-351): 1.71e-12: 67.8: 43.10
+	Hs
		924630 SPD2A_HUMAN (1-631): 1.05e-46: 180: 14.72		GRB2_HUMAN (295-351): 1.51e-12: 67.8: 43.10