HitPredict

Interactor 1: ZBT46 (Q86UZ6)
Zinc finger and BTB domain-containing protein 46 (BTB-ZF protein expressed in effector lymphocytes) (BZEL) (BTB/POZ domain-containing protein 4) (Zinc finger protein 340)
Gene: ZBTB46

Interactor 2: FBW1A (Q9Y297)
F-box/WD repeat-containing protein 1A (E3RSIkappaB) (Epididymis tissue protein Li 2a) (F-box and WD repeats protein beta-TrCP) (pIkappaBalpha-E3 receptor subunit)
Gene: BTRC

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.74	0.60	0.667

Property	Details
Experiments	26186194, 28514442, 33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000122 - negative regulation of transcription by RNA polymerase II
Homologous interactions	10

Homologous interactions

Color coding for hit scores

	1 589 Hs			1 605
+	Hs
		1335872 ZBT34_HUMAN (7-500): 1.07e-78: 258: 19.56		FBW1A_HUMAN (1-605): 0: 557: 100.00
+	Hs
		1289780 ZBT46_HUMAN (1-589): 2.2e-115: 357: 100.00		FBW1B_HUMAN (1-493): 1.88e-73: 246: 18.42
+	Hs
		1335871 ZBT34_HUMAN (7-500): 1.07e-78: 258: 19.56		FBW1B_HUMAN (1-493): 1.88e-73: 246: 18.42
+	Hs
		600454 ZKSC1_HUMAN (129-540): 3.15e-67: 230: 17.23		FBW1B_HUMAN (1-493): 1.88e-73: 246: 18.42
+	Hs
		600433 ZKSC1_HUMAN (129-540): 3.15e-67: 230: 17.23		FBXW7_HUMAN (180-487): 3.12e-68: 236: 22.86
+	Hs
		1246162 ZBTB3_HUMAN (8-466): 3.78e-114: 353: 23.54		TRAF7_HUMAN (292-408): 9.13e-10: 63.5: 29.75
+	Mm
		965391 ZBT7B_MOUSE (10-492): 4.74e-78: 258: 19.72		WDR5_MOUSE (495-604): 1.12e-20: 95.4: 20.18
+	Hs
		832799 BCL6_HUMAN (131-504): 2.93e-47: 178: 16.62		TBL1R_HUMAN (501-605): 6.02e-15: 79.6: 16.67
+	Hs
		166471 BACH1_HUMAN (9-126): 5.4e-15: 80.5: 38.14		PLRG1_HUMAN (417-604): 4.83e-38: 149: 23.47
+	Hs
		517636 ZBT48_HUMAN (356-468): 1.15e-16: 85.6: 20.51		WDR5_HUMAN (495-604): 1.12e-20: 95.4: 20.18