HitPredict

Interactor 1: VRK2 (Q86Y07)
Serine/threonine-protein kinase VRK2 (EC 2.7.11.1) (Vaccinia-related kinase 2)
Gene: VRK2

Interactor 2: MIRO2 (Q8IXI1)
Mitochondrial Rho GTPase 2 (MIRO-2) (hMiro-2) (EC 3.6.5.-) (Ras homolog gene family member T2)
Gene: RHOT2

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.80	0.553

Property	Details
Experiments	32877691
Identification Methods	proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	Pkinase~Ras
Common GO terms	-
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 508 Hs			1 618
+	Hs
		581149 VRK2_HUMAN (1-508): 4.79e-116: 353: 100.00		RAC2_HUMAN (3-183): 1.38e-79: 251: 27.69
+	Hs
		953544 VRK2_HUMAN (1-508): 4.79e-116: 353: 100.00		RAC3_HUMAN (3-168): 9.64e-79: 249: 27.22
+	Hs
		955346 VRK2_HUMAN (1-508): 4.79e-116: 353: 100.00		CDC42_HUMAN (3-172): 5.7e-77: 244: 25.54
+	Hs
		1144991 VRK2_HUMAN (1-508): 4.79e-116: 353: 100.00		RAB35_HUMAN (5-168): 3.57e-76: 242: 24.70
+	Hs
		581132 MARK2_HUMAN (3-474): 2.07e-109: 344: 12.65		RAC2_HUMAN (3-183): 1.38e-79: 251: 27.69
+	Hs
		953523 MARK2_HUMAN (3-474): 2.07e-109: 344: 12.65		RAC3_HUMAN (3-168): 9.64e-79: 249: 27.22
+	Hs
		1015573 VRK2_HUMAN (1-508): 4.79e-116: 353: 100.00		RHOG_HUMAN (3-170): 1.69e-74: 238: 27.47
+	Hs
		988499 VRK2_HUMAN (1-508): 4.79e-116: 353: 100.00		RAC1_HUMAN (3-181): 3.96e-74: 237: 26.43
+	Hs
		955318 MARK2_HUMAN (3-474): 2.07e-109: 344: 12.65		CDC42_HUMAN (3-172): 5.7e-77: 244: 25.54
+	Hs
		976387 VRK2_HUMAN (1-508): 4.79e-116: 353: 100.00		RB11A_HUMAN (5-202): 4.27e-72: 232: 19.00
+	Hs
		976359 MARK2_HUMAN (3-474): 2.07e-109: 344: 12.65		RB11A_HUMAN (5-202): 4.27e-72: 232: 19.00
+	Hs
		962234 VRK2_HUMAN (1-508): 4.79e-116: 353: 100.00		RHOA_HUMAN (6-168): 1.75e-11: 65.5: 28.25
+	Hs
		1294504 VRK2_HUMAN (1-508): 4.79e-116: 353: 100.00		RHOF_HUMAN (2-167): 3.39e-11: 65.1: 26.67
+	Hs
		466340 VRK2_HUMAN (1-508): 4.79e-116: 353: 100.00		RHOC_HUMAN (6-168): 3.88e-11: 64.3: 28.25
+	Hs
		126680 VRK2_HUMAN (1-508): 4.79e-116: 353: 100.00		RHOD_HUMAN (3-167): 1.27e-10: 63.2: 28.89
+	Hs
		978108 MARK2_HUMAN (3-474): 2.07e-109: 344: 12.65		RHOB_HUMAN (6-168): 4.59e-13: 70.1: 29.38
+	Hs
		962195 MARK2_HUMAN (3-474): 2.07e-109: 344: 12.65		RHOA_HUMAN (6-168): 1.75e-11: 65.5: 28.25
+	Hs
		466323 MARK2_HUMAN (3-474): 2.07e-109: 344: 12.65		RHOC_HUMAN (6-168): 3.88e-11: 64.3: 28.25
+	Hs
		126664 MARK2_HUMAN (3-474): 2.07e-109: 344: 12.65		RHOD_HUMAN (3-167): 1.27e-10: 63.2: 28.89
+	Hs
		601344 MARK2_HUMAN (3-474): 2.07e-109: 344: 12.65		RHOQ_HUMAN (5-169): 2.03e-10: 62.8: 26.26