HitPredict

Interactor 1: RING2 (Q99496)
E3 ubiquitin-protein ligase RING2 (EC 2.3.2.27) (Huntingtin-interacting protein 2-interacting protein 3) (HIP2-interacting protein 3) (Protein DinG) (RING finger protein 1B) (RING1b) (RING finger protein 2) (RING finger protein BAP-1) (RING-type E3 ubiquitin transferase RING2)
Gene: RNF2

Interactor 2: PCGF1 (Q9BSM1)
Polycomb group RING finger protein 1 (Nervous system Polycomb-1) (NSPc1) (RING finger protein 68)
Gene: PCGF1

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.97	1.00	0.987

Property	Details
Experiments	24457600, 26496610, 26151332, 27705803, 29985131, 22325352, 22493164, 26687479, 27505670, 32296183, 24981860, 33961781, 18460542, 16943429, unassigned1304
Identification Methods	affinity chromatography technology, pull down, two hybrid, anti tag coimmunoprecipitation, tandem affinity purification, two hybrid prey pooling approach, two hybrid array, validated two hybrid
Interaction Type	physical association, direct interaction, association

Property	Details
Interacting Pfam domains	RAWUL~RAWUL, zf-C3HC4_2~zf-C3HC4_2
Common GO terms	GO:0000122 - negative regulation of transcription by RNA polymerase II GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0006338 - chromatin remodeling GO:0031519 - PcG protein complex and 1 others more... GO:0035102 - PRC1 complex
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 336 Hs			1 259
+	Mm
		1246747 RING2_MOUSE (1-336): 4.78e-112: 330: 99.70		PCGF1_MOUSE (1-259): 1.69e-82: 249: 98.07
+	Hs
		718129 RING2_HUMAN (1-336): 4.99e-112: 330: 100.00		BMI1_HUMAN (30-255): 1.92e-63: 203: 35.29
+	Mm
		639478 RING2_MOUSE (1-336): 4.78e-112: 330: 99.70		BMI1_MOUSE (30-255): 1.56e-62: 200: 35.59
+	Dr
		1186371 RING2_DANRE (1-336): 1.45e-108: 321: 89.29		BMI1B_DANRE (30-255): 6.8e-65: 207: 36.44
+	Hs
		718420 RING2_HUMAN (1-336): 4.99e-112: 330: 100.00		PCGF2_HUMAN (30-255): 4.65e-59: 192: 35.57
+	Dr
		1193368 RING2_DANRE (1-336): 1.45e-108: 321: 89.29		BMI1A_DANRE (30-255): 2.14e-61: 197: 35.59
+	Mm
		620793 RING2_MOUSE (1-336): 4.78e-112: 330: 99.70		PCGF2_MOUSE (30-255): 2.33e-56: 185: 35.98
+	Hs
		1108533 RING2_HUMAN (1-336): 4.99e-112: 330: 100.00		PCGF3_HUMAN (32-257): 1.89e-56: 182: 38.68
+	Mm
		1207257 RING2_MOUSE (1-336): 4.78e-112: 330: 99.70		PCGF3_MOUSE (32-257): 3.72e-55: 179: 39.26
+	Hs
		1304081 RING2_HUMAN (1-336): 4.99e-112: 330: 100.00		PCGF6_HUMAN (26-252): 6.21e-45: 156: 36.05
+	Mm
		1112809 RING2_MOUSE (1-336): 4.78e-112: 330: 99.70		PCGF5_MOUSE (30-257): 5.44e-45: 153: 29.80
+	Hs
		1197582 RING2_HUMAN (1-336): 4.99e-112: 330: 100.00		PCGF5_HUMAN (30-257): 3.38e-44: 151: 29.41
+	Mm
		1307909 RING2_MOUSE (1-336): 4.78e-112: 330: 99.70		PCGF6_MOUSE (26-252): 3.04e-42: 149: 36.48
+	Hs
		1304059 RING2_HUMAN (1-336): 4.99e-112: 330: 100.00		RING2_HUMAN (24-259): 7.12e-39: 140: 16.88
+	Mm
		1321732 RING2_MOUSE (1-336): 4.78e-112: 330: 99.70		RING2_MOUSE (24-259): 5.08e-39: 140: 16.88
+	Mm
		193415 RING2_MOUSE (1-336): 4.78e-112: 330: 99.70		RING1_MOUSE (24-155): 5.39e-33: 125: 20.59
+	Hs
		1019359 RING2_HUMAN (1-336): 4.99e-112: 330: 100.00		TRI26_HUMAN (32-223): 6.79e-32: 124: 19.90
+	Hs
		988012 RING2_HUMAN (1-336): 4.99e-112: 330: 100.00		RING1_HUMAN (24-155): 3.14e-32: 123: 20.59
+	Mm
		193403 RING1_MOUSE (6-336): 1.23e-70: 227: 51.49		PCGF2_MOUSE (30-255): 2.33e-56: 185: 35.98
+	Mm
		193402 RING1_MOUSE (6-336): 1.23e-70: 227: 51.49		RING1_MOUSE (24-155): 5.39e-33: 125: 20.59