HitPredict - High confidence protein-protein interactions

Method score	Annotation score	Interaction score
0.97	1.00	0.987

Method score

Annotation score

Interaction score

0.97

1.00

0.987

Property	Details
Experiments	12624112, 25098452, 19805025, 28205554, 31077413, 11416155, 16142216, 11689443, 11920685, 25633196, 17724081, 20213747, 17541429, 14761963, 16316999, 17937911, 21771788, 9743501
Identification Methods	enzymatic study, affinity chromatography technology, fluorescent resonance energy transfer, anti tag coimmunoprecipitation, protein kinase assay, molecular sieving, cosedimentation in solution, x-ray crystallography, in-gel kinase assay, coimmunoprecipitation
Interaction Type	direct interaction, physical association, phosphorylation reaction

Property

Details

Experiments

12624112, 25098452, 19805025, 28205554, 31077413, 11416155, 16142216, 11689443, 11920685, 25633196, 17724081, 20213747, 17541429, 14761963, 16316999, 17937911, 21771788, 9743501

Identification Methods

enzymatic study, affinity chromatography technology, fluorescent resonance energy transfer, anti tag coimmunoprecipitation, protein kinase assay, molecular sieving, cosedimentation in solution, x-ray crystallography, in-gel kinase assay, coimmunoprecipitation

Interaction Type

direct interaction, physical association, phosphorylation reaction

Property	Details
Interacting Pfam domains	ASK_PH~MAP3K_TRAF_bd, Pkinase~Pkinase
Common GO terms	GO:0000165 - MAPK cascade GO:0000287 - magnesium ion binding GO:0002931 - response to ischemia GO:0004672 - protein kinase activity GO:0004674 - protein serine/threonine kinase activity and 42 others more... GO:0004706 - JUN kinase kinase kinase activity GO:0004709 - MAP kinase kinase kinase activity GO:0005524 - ATP binding GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0006468 - protein phosphorylation GO:0007254 - JNK cascade GO:0008631 - intrinsic apoptotic signaling pathway in response to oxidative stress GO:0009897 - external side of plasma membrane GO:0010666 - positive regulation of cardiac muscle cell apoptotic process GO:0019901 - protein kinase binding GO:0019903 - protein phosphatase binding GO:0019904 - protein domain specific binding GO:0032991 - protein-containing complex GO:0034198 - cellular response to amino acid starvation GO:0034976 - response to endoplasmic reticulum stress GO:0036480 - neuron intrinsic apoptotic signaling pathway in response to oxidative stress GO:0038066 - p38MAPK cascade GO:0042803 - protein homodimerization activity GO:0043065 - positive regulation of apoptotic process GO:0043280 - positive regulation of cysteine-type endopeptidase activity involved in apoptotic process GO:0043507 - positive regulation of JUN kinase activity GO:0045087 - innate immune response GO:0045663 - positive regulation of myoblast differentiation GO:0045860 - positive regulation of protein kinase activity GO:0045893 - positive regulation of DNA-templated transcription GO:0046330 - positive regulation of JNK cascade GO:0051402 - neuron apoptotic process GO:0051403 - stress-activated MAPK cascade GO:0070059 - intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress GO:0070301 - cellular response to hydrogen peroxide GO:0071356 - cellular response to tumor necrosis factor GO:0072577 - endothelial cell apoptotic process GO:0090398 - cellular senescence GO:0097190 - apoptotic signaling pathway GO:0097300 - programmed necrotic cell death GO:0106310 - protein serine kinase activity GO:1900745 - positive regulation of p38MAPK cascade GO:1902170 - cellular response to reactive nitrogen species GO:1902911 - protein kinase complex GO:1904707 - positive regulation of vascular associated smooth muscle cell proliferation GO:1990604 - IRE1-TRAF2-ASK1 complex
Homologous interactions	17