HitPredict

Interactor 1: CDK19 (Q9BWU1)
Cyclin-dependent kinase 19 (EC 2.7.11.22) (CDC2-related protein kinase 6) (Cell division cycle 2-like protein kinase 6) (Cell division protein kinase 19) (Cyclin-dependent kinase 11) (Death-preventing kinase)
Gene: CDK19

Interactor 2: MED17 (Q9NVC6)
Mediator of RNA polymerase II transcription subunit 17 (Activator-recruited cofactor 77 kDa component) (ARC77) (Cofactor required for Sp1 transcriptional activation subunit 6) (CRSP complex subunit 6) (Mediator complex subunit 17) (Thyroid hormone receptor-associated protein complex 80 kDa component) (Trap80) (Transcriptional coactivator CRSP77) (Vitamin D3 receptor-interacting protein complex 80 kDa component) (DRIP80)
Gene: MED17

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.92	0.60	0.746

Property	Details
Experiments	24981860, 33961781, 26186194, 23749998, 28514442, 32707033, 23602568
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation, pull down, tandem affinity purification
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm
Homologous interactions	4

Homologous interactions

Color coding for hit scores

	1 502 Hs			1 651
+	Hs
		826364 CDK8_HUMAN (1-502): 1.77e-150: 439: 76.69		MED17_HUMAN (1-651): 0: 1032: 100.00
+	Hs
		73045 B4DUB1_HUMAN (152-502): 1.59e-138: 406: 100.00		MED17_HUMAN (1-651): 0: 1032: 100.00
+	Dm
		1364509 CDK8_DROME (1-413): 7.19e-138: 407: 77.24		MED17_DROME (6-647): 0: 849: 42.19
+	Hs
		841334 CDK7_HUMAN (27-354): 7.4e-56: 191: 38.21		MED17_HUMAN (1-651): 0: 1032: 100.00