HitPredict

Interactor 1: CHD3 (Q12873)
Chromodomain-helicase-DNA-binding protein 3 (CHD-3) (EC 3.6.4.-) (ATP-dependent helicase CHD3) (Mi-2 autoantigen 240 kDa protein) (Mi2-alpha) (Zinc finger helicase) (hZFH)
Gene: CHD3

Interactor 2: CHD4 (Q14839)
Chromodomain-helicase-DNA-binding protein 4 (CHD-4) (EC 3.6.4.-) (ATP-dependent helicase CHD4) (Mi-2 autoantigen 218 kDa protein) (Mi2-beta)
Gene: CHD4

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.86 1.00 0.931

The method score is based on:

Property Details
Experiments 24981860, 32744500, 9885572, 35235311, 35575683, 40437099
Identification Methods affinity chromatography technology, cross-linking study
Interaction Type physical association

The annotation score is based on:

Property Details
Interacting Pfam domains CHDCT2~CHDCT2, CHDCT2~CHDII_SANT-like, CHDII_SANT-like~CHDII_SANT-like, Chromo~Chromo, Chromo~PHD, Chromo~SNF2-rel_dom, Helicase_C~Helicase_C, Helicase_C~SNF2-rel_dom, PHD~PHD, SNF2-rel_dom~SNF2-rel_dom
Common GO terms GO:0000122 - negative regulation of transcription by RNA polymerase II
GO:0000785 - chromatin
GO:0003677 - DNA binding
GO:0003682 - chromatin binding
GO:0004386 - helicase activity
and 15 others

more...
Homologous interactions 16

Homologous interactions

Color coding for hit scores

1 2000
Hs

1 1912
+ Hs
+ Hs
+ Hs
+ Hs
+ Dm
+ Hs
+ Hs
+ Hs
+ Hs
+ Dm
+ Sc
+ Sp
+ Hs
+ Hs
+ Pf
+ Sc

Service provided by Combinatics, Japan

Last updated: 11Aug2025