HitPredict

Interactor 1: WWTR1 (Q9GZV5)
WW domain-containing transcription regulator protein 1 (Transcriptional coactivator with PDZ-binding motif)
Gene: WWTR1

Interactor 2: FBW1A (Q9Y297)
F-box/WD repeat-containing protein 1A (E3RSIkappaB) (Epididymis tissue protein Li 2a) (F-box and WD repeats protein beta-TrCP) (pIkappaBalpha-E3 receptor subunit)
Gene: BTRC

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.95	0.60	0.756

Property	Details
Experiments	26091241, 25900982, 21189257, 20412773, 26186194, 26116754, 28018973, 28514442, 33961781, 36598329, 22078877
Identification Methods	affinity chromatography technology, proximity labelling technology, pull down, anti tag coimmunoprecipitation, anti bait coimmunoprecipitation
Interaction Type	physical association, direct interaction, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005654 - nucleoplasm GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0016567 - protein ubiquitination GO:0031146 - SCF-dependent proteasomal ubiquitin-dependent protein catabolic process
Homologous interactions	16

Homologous interactions

Color coding for hit scores

	1 400 Hs			1 605
+	Mm
		1112928 WWTR1_MOUSE (1-400): 7.96e-120: 355: 91.00		FBW1A_MOUSE (1-605): 0: 547: 98.68
+	Hs
		809040 YAP1_HUMAN (14-400): 3.72e-97: 300: 41.13		FBW1A_HUMAN (1-605): 0: 551: 100.00
+	Hs
		1326778 WWTR1_HUMAN (1-400): 5.62e-126: 370: 100.00		FBW1B_HUMAN (96-605): 1.89e-143: 428: 85.69
+	Mm
		1131316 WWTR1_MOUSE (1-400): 7.96e-120: 355: 91.00		FBW1B_MOUSE (96-605): 2.25e-143: 428: 85.69
+	Hs
		1336121 SMUF1_HUMAN (55-362): 3.85e-51: 184: 16.62		FBW1A_HUMAN (1-605): 0: 551: 100.00
+	Hs
		809006 YAP1_HUMAN (14-400): 3.72e-97: 300: 41.13		FBW1B_HUMAN (96-605): 1.89e-143: 428: 85.69
+	Hs
		1220099 KIBRA_HUMAN (123-265): 3.08e-45: 169: 18.88		FBW1A_HUMAN (1-605): 0: 551: 100.00
+	Hs
		1334881 SMUF2_HUMAN (156-326): 4.16e-25: 109: 11.92		FBW1A_HUMAN (1-605): 0: 551: 100.00
+	Hs
		808327 NEDD4_HUMAN (109-352): 7.33e-23: 103: 11.00		FBW1A_HUMAN (1-605): 0: 551: 100.00
+	Hs
		1349043 WWOX_HUMAN (111-236): 1.79e-18: 88.4: 21.09		FBW1A_HUMAN (1-605): 0: 551: 100.00
+	Hs
		1220094 KIBRA_HUMAN (123-265): 3.08e-45: 169: 18.88		FBW1B_HUMAN (96-605): 1.89e-143: 428: 85.69
+	Hs
		808825 YAP1_HUMAN (14-400): 3.72e-97: 300: 41.13		FBXW7_HUMAN (76-527): 7.38e-83: 276: 23.71
+	Hs
		808450 YAP1_HUMAN (14-400): 3.72e-97: 300: 41.13		WDR5_HUMAN (458-605): 5.01e-38: 145: 25.33
+	Hs
		125024 WWP2_HUMAN (3-220): 6.4e-59: 207: 19.46		PLRG1_HUMAN (417-604): 2.83e-38: 150: 23.47
+	Hs
		125310 WWP2_HUMAN (3-220): 6.4e-59: 207: 19.46		WDR5_HUMAN (458-605): 5.01e-38: 145: 25.33
+	Dm
		1363649 KIBRA_DROME (122-260): 5.04e-43: 162: 21.58		Q9VDE3_DROME (466-605): 2.66e-30: 126: 29.37