HitPredict

Interactor 1: TXNIP (Q9H3M7)
Thioredoxin-interacting protein (Thioredoxin-binding protein 2) (Vitamin D3 up-regulated protein 1)
Gene: TXNIP

Interactor 2: SMUF2 (Q9HAU4)
E3 ubiquitin-protein ligase SMURF2 (hSMURF2) (EC 2.3.2.26) (HECT-type E3 ubiquitin transferase SMURF2) (SMAD ubiquitination regulatory factor 2) (SMAD-specific E3 ubiquitin-protein ligase 2)
Gene: SMURF2

Species: Homo sapiens

Source: mint

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.43	0.60	0.508

Property	Details
Experiments	15231748
Identification Methods	two hybrid
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000122 - negative regulation of transcription by RNA polymerase II GO:0005737 - cytoplasm GO:0005829 - cytosol
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 391 Hs			1 748
+	Hs
		1192211 TXNIP_HUMAN (1-391): 1.4e-149: 430: 100.00		HUWE1_HUMAN (114-747): 0: 589: 31.46
+	Hs
		808216 ARRD3_HUMAN (2-383): 9.54e-131: 383: 40.35		NEDD4_HUMAN (104-746): 0: 628: 38.73
+	Hs
		1192131 ARRD2_HUMAN (2-383): 5.07e-124: 365: 37.85		HUWE1_HUMAN (114-747): 0: 589: 31.46
+	Hs
		1192130 ARRD4_HUMAN (5-383): 9.16e-123: 362: 43.99		HUWE1_HUMAN (114-747): 0: 589: 31.46
+	Hs
		1299631 TXNIP_HUMAN (1-391): 1.4e-149: 430: 100.00		NED4L_HUMAN (5-396): 1.96e-36: 149: 18.58
+	Hs
		125707 TXNIP_HUMAN (1-391): 1.4e-149: 430: 100.00		WWP2_HUMAN (1-416): 7.64e-26: 116: 17.39
+	Hs
		1294858 TXNIP_HUMAN (1-391): 1.4e-149: 430: 100.00		ITCH_HUMAN (1-426): 2.45e-23: 107: 16.44
+	Hs
		1285052 ARRD3_HUMAN (2-383): 9.54e-131: 383: 40.35		NED4L_HUMAN (5-396): 1.96e-36: 149: 18.58
+	Hs
		1327911 TXNIP_HUMAN (1-391): 1.4e-149: 430: 100.00		WWP1_HUMAN (2-395): 4.38e-20: 97.5: 15.47
+	Hs
		1252808 ARRD2_HUMAN (2-383): 5.07e-124: 365: 37.85		NED4L_HUMAN (5-396): 1.96e-36: 149: 18.58
+	Hs
		125633 ARRD3_HUMAN (2-383): 9.54e-131: 383: 40.35		WWP2_HUMAN (1-416): 7.64e-26: 116: 17.39
+	Hs
		1285047 ARRD3_HUMAN (2-383): 9.54e-131: 383: 40.35		ITCH_HUMAN (1-426): 2.45e-23: 107: 16.44
+	Hs
		125595 ARRD2_HUMAN (2-383): 5.07e-124: 365: 37.85		WWP2_HUMAN (1-416): 7.64e-26: 116: 17.39
+	Hs
		1285070 ARRD3_HUMAN (2-383): 9.54e-131: 383: 40.35		WWP1_HUMAN (2-395): 4.38e-20: 97.5: 15.47
+	Hs
		125586 ARRD4_HUMAN (5-383): 9.16e-123: 362: 43.99		WWP2_HUMAN (1-416): 7.64e-26: 116: 17.39
+	Hs
		1252807 ARRD2_HUMAN (2-383): 5.07e-124: 365: 37.85		ITCH_HUMAN (1-426): 2.45e-23: 107: 16.44
+	Hs
		1285085 ARRD3_HUMAN (2-383): 9.54e-131: 383: 40.35		HECW2_HUMAN (19-281): 8.01e-17: 87.5: 14.80
+	Hs
		1241904 ARRD4_HUMAN (5-383): 9.16e-123: 362: 43.99		ITCH_HUMAN (1-426): 2.45e-23: 107: 16.44
+	Hs
		1252814 ARRD2_HUMAN (2-383): 5.07e-124: 365: 37.85		WWP1_HUMAN (2-395): 4.38e-20: 97.5: 15.47
+	Hs
		1252817 ARRD2_HUMAN (2-383): 5.07e-124: 365: 37.85		HECW2_HUMAN (19-281): 8.01e-17: 87.5: 14.80